Correlations of TGF-βR II, Smad4 and Smad7 expression to clinicopathologic characteristics and prognosis of gastric cancer

Chinese Journal of Cancer

Volumn 28, Issue 5, 2009, Pages

  Lu, Bin ^a   Zhou, Yong Ning ^a   Li, Qiang ^a   Wu, Zheng Qi ^b   Zhang, Zhi Yi ^b   Ji, Rui ^a   Guo, Qing Hong ^a   Liu, Wei ^a  

^a LANZHOU UNIVERSITY   (China)

^b Wuwei Tumor Hospital   (China)

Author keywords

Clinicopathology; Gastric neoplasm; Smad4; Smad7; Survival; TGF R II

Indexed keywords

SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; PROGNOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH CANCER; TISSUE MICROARRAY; TUMOR DIFFERENTIATION;

EID: 78650196468     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Kalo E, Buganim Y, Shapira KE, et al. Mutant p53 attenuates the Smad-dependent transforming growth factor-β1 (TGF-β1) signaling pathway by repressing the expression of TGF-β receptor type II [J]. Mol Cell Biol, 2007, 27 (23): 8228-8242.
2. Masunaga R, Kohno H, Dhar DK, et al. Cyclooxygenase-2 expression correlates with tumor neovascularization and prognosis in human colorectal carcinoma patients [J]. Clin Cancer Res, 2000, 6(10): 4064-4068.
3. Benckert C, Jonas S. Transforming growth factor β 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells [J]. Cancer Res, 2003, 63(5): 1083-1092.
4. Reinacher-Schick A, Baldus SE, Romdhana B, et al. Loss of Smad4 correlates with loss of the invasion suppressor E-cadherin in advanced colorectal carcinomas [J]. J Pathol, 2004, 202(4): 412-420.
5. Muller N, Reinacher-Schick A, Baldus SE, et al. Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells [J]. Oncogene, 2002, 21 (60): 49-58.
6. Massague J, Wotton D. Transcriptional control by the TGFβ-Smad signaling system [J]. EMBO, 2000, 19(8): 1745-1754.
7. Matsuzaki K, Date M, Furukawa F, et al. Regulatory mechanisms for transforming growth factor beta as an autocrine inhibitor in human hepatocellular carcinoma: implications for roles of smads in its growth [J]. Hepatology, 2000, 32 (2): 218-227.
8. Kim YH, Lee HS, Lee HJ, et al. Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas [J]. Ann Oncol, 2004, 15(4): 574-580.
9. Wang L, Huo YY, Zhang KT, et al. Regulatory effect of Smad7 gene on MAPK signal pathway in malignant transformation of immortalized human bronchial epithelial BEP2D cells [J]. Ai Zheng, 2005, 24 (9): 1080-1084. [in Chinese]
10. Wang LH, Kim SH, Lee JH, et al. Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression [J]. Clin Cancer Res, 2007, 13(1): 102-110.
11. Kim JY, Park DY, Kim GH, et al. Smad4 expression in gastric adenoma and adenocarcinoma: frequent loss of expression in diffuse type of gastric adenocarcinoma [J]. Histol Histopathol, 2005, 20(2): 543-549.