Assessment of Hydroxypropyl Methylcellulose, Propylene Glycol, Polysorbate 80, and Hydroxypropyl-β-Cyclodextrin for use in developmental and reproductive toxicology studies

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 89, Issue 6, 2010, Pages 504-516

  Enright, Brian P ^a,b   McIntyre, Barry S ^a,c   Thackaberry, Evan A ^a,d   Treinen, Kimberley A ^a   Kopytek, Stephan J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ABBOTT LABORATORIES   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d GENENTECH INC   (United States)

Author keywords

Embryo; Fertility; Fetus; Hydroxypropyl Methylcellulose; Hydroxypropyl cyclodextrin; Polysorbate 80; Propylene glycol; Rabbit; Rat; Teratology; Toxicity

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; HYDROXYPROPYLMETHYLCELLULOSE; POLYSORBATE 80; PROPYLENE GLYCOL;

ABORTION; ANIMAL EXPERIMENT; ARTICLE; AUTOPSY; BONE MALFORMATION; CESAREAN SECTION; CONTROLLED STUDY; ESTRUS; FEMALE; FERTILITY; FETUS WEIGHT; FOOD INTAKE; MATING; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; RABBIT; RAT; REPRODUCTIVE TOXICITY; TERATOGENICITY; VISCERA; WEIGHT GAIN;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; BETA-CYCLODEXTRINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; EMBRYO, MAMMALIAN; FEMALE; METHYLCELLULOSE; PHARMACEUTICAL VEHICLES; POLYSORBATES; PREGNANCY; PROPYLENE GLYCOL; RABBITS; RATS; REPRODUCTION; TOXICITY TESTS; WEIGHT GAIN;

ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 78650180682     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.20273     Document Type: Article

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