Comprehensive investigation of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-beta-cyclodextrin for use in general toxicology studies

Toxicological Sciences

Volumn 117, Issue 2, 2010, Pages 485-492

  Thackaberry, Evan A ^a   Kopytek, Stephen ^a   Sherratt, Phillip ^a   Trouba, Kevin ^b   McIntyre, Barry ^c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

HP CD; Hydroxypropyl beta cyclodextrin; Polysorbate 80; Propylene glycol; Safety assessment; Tween 80

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HYDROXYPROPYLMETHYLCELLULOSE; POLYSORBATE 80; PROPYLENE GLYCOL;

ADRENAL GLAND; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; BONE MARROW; BRAIN WEIGHT; CLINICAL EXAMINATION; CONTROLLED STUDY; DOG; FEMALE; FOOD INTAKE; HEART; HEART SIZE; HISTOPATHOLOGY; HYPOPHYSIS; KIDNEY SIZE; LIVER SIZE; LUNG; MALE; MONKEY; MOUSE; NONHUMAN; ORGAN WEIGHT; PROSTATE; PROTHROMBIN TIME; RAT; RISK ASSESSMENT; SPLEEN; TESTIS; THYMUS; TOXICOLOGY; UTERUS;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BETA-CYCLODEXTRINS; DIARRHEA; DOGS; FEMALE; LIVER; LIVER FUNCTION TESTS; MACACA FASCICULARIS; MALE; METHYLCELLULOSE; MICE; PHARMACEUTICAL VEHICLES; POLYSORBATES; PROPYLENE GLYCOL; RATS; TOXICITY TESTS;

ANIMALIA; CANIS FAMILIARIS; MACACA FASCICULARIS; MUS; RATTUS; RODENTIA;

EID: 77956919844     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq207     Document Type: Article

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