Diastereoselective synthesis of trans-2,3-dihydrothiophenes via multicomponent reactions of pivaloylacetonitrile, aldehyde, amine, and thiazolidinedione

Synthesis

Volumn , Issue 23, 2010, Pages 3987-3992

  Sun, Jing ^a   Wu, Qun ^a   Xia, Er Yan ^a   Yan, Chao Guo ^a  

^a YANGZHOU UNIVERSITY   (China)

Author keywords

dihydrothiophene; multicomponent reaction; pivaloylacetonitrile; thiazolidinedione

Indexed keywords

AROMATIC ALDEHYDE; DIASTEREOSELECTIVE SYNTHESIS; DIHYDROTHIOPHENE; KNOEVENAGEL CONDENSATION; MICHAEL ADDITIONS; MULTI-COMPONENT REACTIONS; PIVALOYLACETONITRILE; REACTION MECHANISM; RING OPENING; RING-CLOSURE PROCESS; SECONDARY AMINES; THIAZOLIDINEDIONES; THIAZOLIDINES;

ADDITION REACTIONS; ALDEHYDES; REACTION KINETICS; SYNTHESIS (CHEMICAL);

CONDENSATION REACTIONS;

2,4 THIAZOLIDINEDIONE; ACETONITRILE DERIVATIVE; BENZALDEHYDE; MORPHOLINE DERIVATIVE; N [[5 AMINO 3 (4 BROMOPHENYL) 4 (TERT BUTYLCARBONYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]MORPHOLINE 4 CARBOXAMIDE; N [[5 AMINO 3 (4 BROMOPHENYL) 4 (TERT BUTYLCARBONYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PIPERIDINE 1 CARBOXAMIDE; N [[5 AMINO 3 (4 BROMOPHENYL) 4 (TERT BUTYLCARBONYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PYRROLIDINE 1 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (3 CHLOROPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PIPERIDINE 1 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (3 NITROPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]MORPHOLINE 4 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (3 NITROPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PIPERIDINE 1 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 CHLOROPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]MORPHOLINE 4 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 CHLOROPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PIPERIDINE 1 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 FLUOROPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PIPERIDINE 1 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 ISOPROPYLPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PIPERIDINE 1 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 METHOXYPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]MORPHOLINE 4 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 METHOXYPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PIPERIDINE 1 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 METHOXYPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PYRROLIDINE 1 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 METHYLPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]MORPHOLINE 4 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 METHYLPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PIPERIDINE 1 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 TERT BUTYLPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]MORPHOLINE 4 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 (4 TERT BUTYLPHENYL) 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PIPERIDINE 1 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 PHENYL 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]MORPHOLINE 4 CARBOXAMIDE; N [[5 AMINO 4 (TERT BUTYLCARBONYL) 3 PHENYL 2,5 DIHYDROTHIOPHEN 2 YL]CARBONYL]PIPERIDINE 1 CARBOXAMIDE; PIPERIDINE; PIVALOYLACETONITRILE; PYRROLIDINE DERIVATIVE; THIOPHENE DERIVATIVE; TRANS 2,3 DIHYDROTHIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; KNOEVENAGEL CONDENSATION; MICHAEL ADDITION; RING CLOSING METATHESIS; RING OPENING; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

EID: 78650176843     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1258272     Document Type: Article

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