Synthesis, Structure-Activity Relationships, and Mechanism of Drug Resistance of D- and L-β-3′-Fluoro-2′,3′ -unsaturated-4′-thionucleosides as Anti-HIV Agents

Journal of Medicinal Chemistry

Volumn 47, Issue 7, 2004, Pages 1631-1640

  Zhu, Wei ^a   Chong, Youhoon ^a   Choo, Hyunah ^a   Mathews, Judy ^b   Schinazi, Raymond F ^b   Chu, Chung K ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,3 DIDEOXY 2,3 DIDEHYDRO 3 FLUORO 4 THIO BETA LEVO RIBOFURANOSYL) 5 FLUOROCYTOSINE; 1 (2,3 DIDEOXY 2,3 DIDEHYDRO 3 FLUORO 4 THIO BETA LEVO RIBOFURANOSYL)CYTOSINE; 9 (2,3 DIDEOXY 2,3 DIDEHYDRO 3 FLUORO 4 THIO BETA LEVO RIBOFURANOSYL)ADENINE; 9 (2,3 DIDEOXY 2,3 DIDEHYDRO 3 FLUORO 4 THIO BETA LEVO RIBOFURANOSYL)GUANINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ASPARTIC ACID; BETA 3' FLUORO 2',3' UNSATURATED 4' THIONUCLEOSIDE; CYTIDINE TRIPHOSPHATE; CYTOSINE DERIVATIVE; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG RESISTANCE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HUMAN; HUMAN CELL; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; TOXICITY; WILD TYPE;

ANTI-HIV AGENTS; DRUG RESISTANCE, VIRAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; LEUKOCYTES, MONONUCLEAR; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIONUCLEOSIDES;

EID: 1642388408     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0303148     Document Type: Article

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