Mutational analysis of predicted extracellular domains of human growth hormone secretagogue receptor 1a

Regulatory Peptides

Volumn 166, Issue 1-3, 2011, Pages 28-35

  Ueda, Teruhisa ^a   Matsuura, Bunzo ^a   Miyake, Teruki ^a   Furukawa, Shinya ^a   Abe, Masanori ^a   Hiasa, Yoichi ^a   Onji, Morikazu ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Ghrelin; GHRP 6; Growth hormone secretagogue receptor; Receptor mutagenesis

Indexed keywords

CALCIUM; CYSTEINE; G PROTEIN COUPLED RECEPTOR; GHRELIN; GHRELIN RECEPTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE;

ARTICLE; CALCIUM SIGNALING; CELL STIMULATION; CELL STRAIN COS1; CONTROLLED STUDY; DISULFIDE BOND; GENE DELETION; LIGAND BINDING; MUTATIONAL ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; GHRELIN; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, GHRELIN; RECEPTORS, NEUROPEPTIDE; SEQUENCE DELETION;

EID: 78650176430     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2010.08.002     Document Type: Article

References (31)

1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
2. Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M.S., Suganuma T., et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000, 141:4255-4261.
3. Wren A.M., Small C.J., Ward H.L., Murphy K.G., Dakin C.L., Taheri S., et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000, 141:4325-4328.
4. Wren A.M., Small C.J., Fribbens C.V., Neary N.M., Ward H.L., Seal L.J., et al. The hypothalamic mechanisms of the hypophysiotropic action of ghrelin. Neuroendocrinology 2002, 76:316-324.
5. Nagaya N., Moriya J., Yasumura Y., Uematsu M., Ono F., Shimizu W., et al. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 2004, 110:3674-3679.
6. Nagaya N., Itoh T., Murakami S., Oya H., Uematsu M., Miyatake K., et al. Treatment of cachexia with ghrelin in patients with COPD. Chest 2005, 128:1187-1193.
7. Miljic D., Pekic S., Djurovic M., Doknic M., Milic N., Casanueva F.F., et al. Ghrelin has partial or no effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosa. J Clin Endocrinol Metab 2006, 91:1491-1495.
8. Strasser F., Lutz T.A., Maeder M.T., Thuerlimann B., Bueche D., Tschöp M., et al. Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomized, placebo-controlled, double-blind, double-crossover study. Br J Cancer 2008, 98:300-308.
9. DeBoer M.D. Emergence of ghrelin as a treatment for cachexia syndromes. Nutrition 2008, 24:806-814.
10. Deboer M.D., Zhu X., Levasseur P.R., Inui A., Hu Z., Han G., et al. Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. Endocrinology 2008, 149:827-835.
11. Howard A.D., Feighner S.D., Cully D.F., Arena J.P., Liberator P.A., Rosenblum C.I., et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996, 273:974-977.
12. Wang H.J., Geller F., Dempfle A., Schäuble N., Friedel S., Lichtner P., et al. Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature. J Clin Endocrinol Metab 2004, 89:157-162.
13. Pantel J., Legendre M., Cabrol S., Hilal L., Hajaji Y., Morisset S., et al. Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature. J Clin Invest 2006, 116:760-768.
14. Pantel J., Legendre M., Nivot S., Morisset S., Vie-Luton M.P., le Bouc Y., et al. Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor. J Clin Endocrinol Metab 2009, 94:4334-4341.
15. Holst B., Frimurer T.M., Mokrosinski J., Halkjaer T., Cullberg K.B., Underwood C.R., et al. Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor. Mol Pharmacol 2009, 75:44-59.
16. Floquet N., M'Kadmi C., Perahia D., Gagne D., Berge G., Marie J., et al. Activation of the ghrelin receptor is described by a privileged collective motion: a model for constitutive and agonist-induced activation of a sub-class A G protein-coupled receptor (GPCR). J Mol Biol 2010, 395:769-784.
17. Coulie B., Matsuura B., Dong M., Hadac E.M., Pinon D.I., Feighner S.D., et al. Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J Biol Chem 2001, 276:35518-35522.
18. Matsuura B., Dong M., Coulie B., Pinon D.I., Miller L.J. Demonstration of a specific site of covalent labeling of the human motilin receptor using a biologically active photolabile motilin analog. J Pharmacol Exp Ther 2005, 313:1101-1108.
19. Matsuura B., Dong M., Miller L.J. Differential determinants for peptide and non-peptidyl ligand binding to the motilin receptor. J Biol Chem 2002, 277:9834-9839.
20. Matsuura B., Dong M., Naik S., Miller L.J., Onji M. Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity. J Biol Chem 2006, 281:12390-12396.
21. Tokunaga H., Matsuura B., Dong M., Miller L.J., Ueda T., Furukawa S., et al. Mutational analysis of predicted intracellular loop domains of human motilin receptor. Am J Physiol Gastrointest Liver Physiol 2008, 294:G460-G466.
22. Feighner S.D., Tan C.P., McKee K.K., Palyha O.C., Hreniuk D.L., Pong S.S., et al. Receptor for motilin identified in the human gastrointestinal system. Science 1999, 284:2184-2188.
23. Holst B., Cygankiewicz A., Jensen T.H., Ankersen M., Schwartz T.W. High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist. Mol Endocrinol 2003, 17:2201-2210.
24. Feighner S.D., Howard A.D., Prendergast K., Palyha O.C., Hreniuk D.L., Nargund R., et al. Structural requirements for the activation of the human growth hormone secretagogue receptor by peptide and nonpeptide secretagogues. Mol Endocrinol 1998, 12:137-145.
25. Grynkiewicz G., Poenie M., Tsien R.Y. A new generation of calcium indicators with greatly improved fluorescence properties. J Biol Chem 1985, 260:3440-3450.
26. Munson P.J., Rodbard D. LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 1980, 107:220-239.
27. Kolakowski L.F. GCRDb: a G protein-coupled receptor database. Recept Channels 1994, 2:1-7.
28. Holliday N.D., Holst B., Rodionova E.A., Schwartz T.W., Cox H.M. Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor. Mol Endocrinol 2007, 21:3100-3112.
29. Guan X.M., Yu H., Palyha O.C., McKee K.K., Feighner S.D., Sirinathsinghji D.J., et al. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 1997, 48:23-29.
30. Gnanapavan S., Kola B., Bustin S.A., Morris D.G., McGee P., Fairclough P., et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002, 87:2988.
31. Takeshita E., Matsuura B., Dong M., Miller L.J., Matsui H., Onji M. Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract. J Gastroenterol 2006, 41:223-230.