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Volumn 24, Issue 11, 2010, Pages 1717-1724

The neurosteroid dehydroepiandrosterone (DHEA) and its metabolites alter 5-HT neuronal activity via modulation of GABAA receptors

Author keywords

androsterone; DHEA sulphate; dorsal raphe nucleus; electrophysiology

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ANDROSTERONE; GABOXADOL; PRASTERONE; PRASTERONE SULFATE; SEROTONIN;

EID: 78650079014     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109105836     Document Type: Article
Times cited : (30)

References (45)
  • 1
    • 0032949135 scopus 로고    scopus 로고
    • Localisation of dehydroepiandrosterone sulphotransferase in adult rat brain
    • Aldred, S., Waring, RH (1999) Localisation of dehydroepiandrosterone sulphotransferase in adult rat brain. Brain Res Bull 48: 291-296.
    • (1999) Brain Res Bull , vol.48 , pp. 291-296
    • Aldred, S.1    Waring, R.H.2
  • 2
    • 33751101036 scopus 로고    scopus 로고
    • Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: A double-blind, placebo-controlled study
    • Berl
    • Alhaj, HA, Massey, AE, McAllister-Williams, RH (2006) Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study. Psychopharmacology (Berl) 188: 541-551.
    • (2006) Psychopharmacology , vol.188 , pp. 541-551
    • Alhaj, H.A.1    Massey, A.E.2    McAllister-Williams, R.H.3
  • 3
    • 0142195828 scopus 로고    scopus 로고
    • Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo
    • Allers, KA, Sharp, T. (2003) Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo. Neuroscience 122: 193-204.
    • (2003) Neuroscience , vol.122 , pp. 193-204
    • Allers, K.A.1    Sharp, T.2
  • 5
    • 0019431889 scopus 로고
    • Acquired adrenal hyperplasia: With special reference to 3 beta-hydroxysteroid dehydrogenase
    • Bongiovanni, AM (1981) Acquired adrenal hyperplasia: with special reference to 3 beta-hydroxysteroid dehydrogenase. Fertil Steril 35: 599-608.
    • (1981) Fertil Steril , vol.35 , pp. 599-608
    • Bongiovanni, A.M.1
  • 6
    • 0028961676 scopus 로고
    • Adrenarche does not occur in treated patients with congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency
    • Oxf
    • Brunelli, VL, Chiumello, G., David, M., Forest, MG (1995) Adrenarche does not occur in treated patients with congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency. Clin Endocrinol (Oxf) 42: 461-466.
    • (1995) Clin Endocrinol , vol.42 , pp. 461-466
    • Brunelli, V.L.1    Chiumello, G.2    David, M.3    Forest, M.G.4
  • 7
    • 0024264898 scopus 로고
    • Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: Differences related to age and sex
    • Carlstrom, K., Brody, S., Lunell, NO, Lagrelius, A., Mollerstrom, G., Pousette, A., et al. (1988) Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: differences related to age and sex. Maturitas 10: 297-306.
    • (1988) Maturitas , vol.10 , pp. 297-306
    • Carlstrom, K.1    Brody, S.2    Lunell, N.O.3    Lagrelius, A.4    Mollerstrom, G.5    Pousette, A.6
  • 8
    • 0035150675 scopus 로고    scopus 로고
    • Congenital adrenal hyperplasia: From genetics and biochemistry to clinical practice, Part 1
    • Phila
    • Collett-Solberg, PF (2001) Congenital adrenal hyperplasia: from genetics and biochemistry to clinical practice, Part 1. Clin Pediatr (Phila) 40: 1-16.
    • (2001) Clin Pediatr , vol.40 , pp. 1-16
    • Collett-Solberg, P.F.1
  • 9
    • 0018710508 scopus 로고
    • Dissociation of cortisol and adrenal androgen secretion in patients with secondary adrenal insufficiency
    • Cutler Jr, GB, Davis, SE, Johnsonbaugh, RE, Loriaux, DL (1979) Dissociation of cortisol and adrenal androgen secretion in patients with secondary adrenal insufficiency. J Clin Endocrinol Metab 49: 604-609.
    • (1979) J Clin Endocrinol Metab , vol.49 , pp. 604-609
    • Cutler Jr., G.B.1    Davis, S.E.2    Johnsonbaugh, R.E.3    Loriaux, D.L.4
  • 11
    • 0025941858 scopus 로고
    • Receptor binding and electrophysiological effects of dehydroepiandrosterone sulfate, an antagonist of the GABAA receptor
    • Demirgoren, S., Majewska, MD, Spivak, CE, London, ED (1991) Receptor binding and electrophysiological effects of dehydroepiandrosterone sulfate, an antagonist of the GABAA receptor. Neuroscience 45: 127-135.
    • (1991) Neuroscience , vol.45 , pp. 127-135
    • Demirgoren, S.1    Majewska, M.D.2    Spivak, C.E.3    London, E.D.4
  • 12
    • 0026662235 scopus 로고
    • GABA-active steroids: Endogenous modulators of GABA-gated chloride ion conductance
    • Deutsch, SI, Mastropaolo, J., Hitri, A. (1992) GABA-active steroids: endogenous modulators of GABA-gated chloride ion conductance. Clin Neuropharmacol 15: 352-364.
    • (1992) Clin Neuropharmacol , vol.15 , pp. 352-364
    • Deutsch, S.I.1    Mastropaolo, J.2    Hitri, A.3
  • 13
    • 29344465142 scopus 로고    scopus 로고
    • Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain
    • Ebner, MJ, Corol, DI, Havlikova, H., Honour, JW, Fry, JP (2006) Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain. Endocrinology 147: 179-190.
    • (2006) Endocrinology , vol.147 , pp. 179-190
    • Ebner, M.J.1    Corol, D.I.2    Havlikova, H.3    Honour, J.W.4    Fry, J.P.5
  • 14
    • 0042476369 scopus 로고    scopus 로고
    • Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current
    • Eisenman, LN, He, Y., Fields, C., Zorumski, CF, Mennerick, S. (2003) Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current. J Physiol 550: 679-691.
    • (2003) J Physiol , vol.550 , pp. 679-691
    • Eisenman, L.N.1    He, Y.2    Fields, C.3    Zorumski, C.F.4    Mennerick, S.5
  • 15
    • 12444324515 scopus 로고    scopus 로고
    • Changes in gamma-aminobutyric acid tone and extracellular serotonin in the dorsal raphe nucleus over the rat estrous cycle
    • Felton, TM, Auerbach, SB (2004) Changes in gamma-aminobutyric acid tone and extracellular serotonin in the dorsal raphe nucleus over the rat estrous cycle. Neuroendocrinology 80: 152-157.
    • (2004) Neuroendocrinology , vol.80 , pp. 152-157
    • Felton, T.M.1    Auerbach, S.B.2
  • 16
    • 51649093971 scopus 로고    scopus 로고
    • Role of neuroendocrine pathways in cognitive decline during aging
    • Ferrari, E., Magri, F. (2008) Role of neuroendocrine pathways in cognitive decline during aging. Ageing Res Rev 7: 225-233.
    • (2008) Ageing Res Rev , vol.7 , pp. 225-233
    • Ferrari, E.1    Magri, F.2
  • 17
    • 0018255337 scopus 로고
    • Benzodiazepines: Potentiation of a GABA inhibitory response in the dorsal raphe nucleus
    • Gallager, DW (1978) Benzodiazepines: potentiation of a GABA inhibitory response in the dorsal raphe nucleus. Eur J Pharmacol 49: 133-143.
    • (1978) Eur J Pharmacol , vol.49 , pp. 133-143
    • Gallager, D.W.1
  • 18
    • 0032988910 scopus 로고    scopus 로고
    • Differential blockade of gamma-aminobutyric acid type A receptors by the neuroactive steroid dehydroepiandrosterone sulfate in posterior and intermediate pituitary
    • Hansen, SL, Fjalland, B., Jackson, MB (1999) Differential blockade of gamma-aminobutyric acid type A receptors by the neuroactive steroid dehydroepiandrosterone sulfate in posterior and intermediate pituitary. Mol Pharmacol 55: 489-496.
    • (1999) Mol Pharmacol , vol.55 , pp. 489-496
    • Hansen, S.L.1    Fjalland, B.2    Jackson, M.B.3
  • 19
    • 0032562092 scopus 로고    scopus 로고
    • Modulation of GABA-gated chloride ion influx in the brain by dehydroepiandrosterone and its metabolites
    • Imamura, M., Prasad, C. (1998) Modulation of GABA-gated chloride ion influx in the brain by dehydroepiandrosterone and its metabolites. Biochem Biophys Res Commun 243: 771-775.
    • (1998) Biochem Biophys Res Commun , vol.243 , pp. 771-775
    • Imamura, M.1    Prasad, C.2
  • 20
    • 0033629748 scopus 로고    scopus 로고
    • Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: Association with an up-regulation of the cyclic AMP pathway
    • Jolas, T., Nestler, EJ, Aghajanian, GK (2000) Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway. Neuroscience 95: 433-443.
    • (2000) Neuroscience , vol.95 , pp. 433-443
    • Jolas, T.1    Nestler, E.J.2    Aghajanian, G.K.3
  • 21
    • 4444376990 scopus 로고    scopus 로고
    • GABA receptor modulation of 5-HT neuronal firing: Characterization and effect of moderate in vivo variations in glucocorticoid levels
    • Judge, SJ, Ingram, CD, Gartside, SE (2004) GABA receptor modulation of 5-HT neuronal firing: characterization and effect of moderate in vivo variations in glucocorticoid levels. Neurochem Int 45: 1057-1065.
    • (2004) Neurochem Int , vol.45 , pp. 1057-1065
    • Judge, S.J.1    Ingram, C.D.2    Gartside, S.E.3
  • 22
    • 33751179894 scopus 로고    scopus 로고
    • The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity
    • Kaura, V., Ingram, CD, Gartside, SE, Young, AH, Judge, SJ (2007) The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity. Eur Neuropsychopharmacol 17: 108-115.
    • (2007) Eur Neuropsychopharmacol , vol.17 , pp. 108-115
    • Kaura, V.1    Ingram, C.D.2    Gartside, S.E.3    Young, A.H.4    Judge, S.J.5
  • 24
    • 34548406452 scopus 로고    scopus 로고
    • Bioavailability and metabolism of oral and percutaneous dehydroepiandrosterone in postmenopausal women
    • DOI 10.1016/j.jsbmb.2007.02.007, PII S0960076007001513
    • Labrie, F., Belanger, A., Labrie, C., Candas, B., Cusan, L., Gomez, JL (2007 b) Bioavailability and metabolism of oral and percutaneous dehydroepiandrosterone in postmenopausal women. J Steroid Biochem Mol Biol 107: 57-69. (Pubitemid 47362670)
    • (2007) Journal of Steroid Biochemistry and Molecular Biology , vol.107 , Issue.1-2 , pp. 57-69
    • Labrie, F.1    Belanger, A.2    Labrie, C.3    Candas, B.4    Cusan, L.5    Gomez, J.L.6
  • 25
    • 0021232592 scopus 로고
    • Modulation by calcium of gamma-aminobutyric acid (GABA) binding to GABAA and GABAB recognition sites in rat brain. Involvement of different mechanisms
    • Majewska, MD, Chuang, DM (1984) Modulation by calcium of gamma-aminobutyric acid (GABA) binding to GABAA and GABAB recognition sites in rat brain. Involvement of different mechanisms. Mol Pharmacol 25: 352-359.
    • (1984) Mol Pharmacol , vol.25 , pp. 352-359
    • Majewska, M.D.1    Chuang, D.M.2
  • 26
    • 0025091447 scopus 로고
    • The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor
    • Majewska, MD, Demirgoren, S., Spivak, CE, London, ED (1990) The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor. Brain Res 526: 143-146.
    • (1990) Brain Res , vol.526 , pp. 143-146
    • Majewska, M.D.1    Demirgoren, S.2    Spivak, C.E.3    London, E.D.4
  • 27
    • 38549166646 scopus 로고    scopus 로고
    • Neurosteroid modulation of GABAA receptors: Molecular determinants and significance in health and disease
    • Mitchell, EA, Herd, MB, Gunn, BG, Lambert, JJ, Belelli, D. (2008) Neurosteroid modulation of GABAA receptors: molecular determinants and significance in health and disease. Neurochem Int 52: 588-595.
    • (2008) Neurochem Int , vol.52 , pp. 588-595
    • Mitchell, E.A.1    Herd, M.B.2    Gunn, B.G.3    Lambert, J.J.4    Belelli, D.5
  • 28
    • 34748914396 scopus 로고    scopus 로고
    • The steroid sulfatase inhibitor COUMATE attenuates rather than enhances access of dehydroepiandrosterone sulfate to the brain in the mouse
    • Nicolas, LB, Fry, JP (2007) The steroid sulfatase inhibitor COUMATE attenuates rather than enhances access of dehydroepiandrosterone sulfate to the brain in the mouse. Brain Res 1174: 92-96.
    • (2007) Brain Res , vol.1174 , pp. 92-96
    • Nicolas, L.B.1    Fry, J.P.2
  • 29
    • 27144474930 scopus 로고    scopus 로고
    • Changes in basal hypothalamo-pituitary-adrenal activity during exercise training are centrally mediated
    • Park, E., Chan, O., Li, Q., Kiraly, M., Matthews, SG, Vranic, M., et al. (2005) Changes in basal hypothalamo-pituitary-adrenal activity during exercise training are centrally mediated. Am J Physiol Regul Integr Comp Physiol 289: R1360 - R1371.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.289
    • Park, E.1    Chan, O.2    Li, Q.3    Kiraly, M.4    Matthews, S.G.5    Vranic, M.6
  • 30
    • 0033614716 scopus 로고    scopus 로고
    • Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites
    • Park-Chung, M., Malayev, A., Purdy, RH, Gibbs, TT, Farb, DH (1999) Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites. Brain Res 830: 72-87.
    • (1999) Brain Res , vol.830 , pp. 72-87
    • Park-Chung, M.1    Malayev, A.2    Purdy, R.H.3    Gibbs, T.T.4    Farb, D.H.5
  • 32
    • 0034736184 scopus 로고    scopus 로고
    • GABA(A) receptors: Immunocytochemical distribution of 13 subunits in the adult rat brain
    • Pirker, S., Schwarzer, C., Wieselthaler, A., Sieghart, W., Sperk, G. (2000) GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101: 815-850.
    • (2000) Neuroscience , vol.101 , pp. 815-850
    • Pirker, S.1    Schwarzer, C.2    Wieselthaler, A.3    Sieghart, W.4    Sperk, G.5
  • 33
    • 0033765025 scopus 로고    scopus 로고
    • Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders
    • Ressler, KJ, Nemeroff, CB (2000) Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12 (Suppl. 1). 2-19.
    • (2000) Depress Anxiety , vol.12 , Issue.1 , pp. 2-19
    • Ressler, K.J.1    Nemeroff, C.B.2
  • 34
    • 0035858781 scopus 로고    scopus 로고
    • Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat
    • Schwarzer, C., Berresheim, U., Pirker, S., Wieselthaler, A., Fuchs, K., Sieghart, W., et al. (2001) Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat. J Comp Neurol 433: 526-549.
    • (2001) J Comp Neurol , vol.433 , pp. 526-549
    • Schwarzer, C.1    Berresheim, U.2    Pirker, S.3    Wieselthaler, A.4    Fuchs, K.5    Sieghart, W.6
  • 36
    • 0023266639 scopus 로고
    • GABA, benzodiazepine and serotonergic receptor development in the dorsal raphe nucleus: Electrophysiological studies
    • Smith, D., Gallager, D. (1987) GABA, benzodiazepine and serotonergic receptor development in the dorsal raphe nucleus: electrophysiological studies. Brain Res 432: 191-198.
    • (1987) Brain Res , vol.432 , pp. 191-198
    • Smith, D.1    Gallager, D.2
  • 37
    • 0037312851 scopus 로고    scopus 로고
    • Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia
    • Strous, RD, Maayan, R., Lapidus, R., Stryjer, R., Lustig, M., Kotler, M., et al. (2003) Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia. Arch Gen Psychiatry 60: 133-141.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 133-141
    • Strous, R.D.1    Maayan, R.2    Lapidus, R.3    Stryjer, R.4    Lustig, M.5    Kotler, M.6
  • 38
    • 0029822667 scopus 로고    scopus 로고
    • Differential regulation of 5-hydroxytryptamine release by GABAA and GABAB receptors in midbrain raphe nuclei and forebrain of rats
    • Tao, R., Ma, Z., Auerbach, SB (1996) Differential regulation of 5-hydroxytryptamine release by GABAA and GABAB receptors in midbrain raphe nuclei and forebrain of rats. Br J Pharmacol 119: 1375-1384.
    • (1996) Br J Pharmacol , vol.119 , pp. 1375-1384
    • Tao, R.1    Ma, Z.2    Auerbach, S.B.3
  • 39
    • 53149107135 scopus 로고    scopus 로고
    • Cognitive dysfunction in neuropsychiatric disorders: Selected serotonin receptor subtypes as therapeutic targets
    • Terry Jr, AV, Buccafusco, JJ, Wilson, C. (2008) Cognitive dysfunction in neuropsychiatric disorders: selected serotonin receptor subtypes as therapeutic targets. Behav Brain Res 195: 30-38.
    • (2008) Behav Brain Res , vol.195 , pp. 30-38
    • Terry Jr., A.V.1    Buccafusco, J.J.2    Wilson, C.3
  • 40
    • 0034913454 scopus 로고    scopus 로고
    • Age, body mass index, race and other determinants of steroid hormone variability: The HERITAGE Family Study
    • Ukkola, O., Gagnon, J., Rankinen, T., Thompson, PA, Hong, Y., Leon, AS, et al. (2001) Age, body mass index, race and other determinants of steroid hormone variability: the HERITAGE Family Study. Eur J Endocrinol 145: 1-9.
    • (2001) Eur J Endocrinol , vol.145 , pp. 1-9
    • Ukkola, O.1    Gagnon, J.2    Rankinen, T.3    Thompson, P.A.4    Hong, Y.5    Leon, A.S.6
  • 41
    • 0034993140 scopus 로고    scopus 로고
    • Salivary cortisol and DHEA: Association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation
    • van Niekerk, JK, Huppert, FA, Herbert, J. (2001) Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation. Psychoneuroendocrinology 26: 591-612.
    • (2001) Psychoneuroendocrinology , vol.26 , pp. 591-612
    • Van Niekerk, J.K.1    Huppert, F.A.2    Herbert, J.3
  • 42
    • 0021023465 scopus 로고
    • Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices
    • Vandermaelen, CP, Aghajanian, GK (1983) Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Res 289: 109-119.
    • (1983) Brain Res , vol.289 , pp. 109-119
    • Vandermaelen, C.P.1    Aghajanian, G.K.2
  • 43
    • 0037263640 scopus 로고    scopus 로고
    • Electrophysiological evidence for convergence of inputs from the medial prefrontal cortex and lateral habenula on single neurons in the dorsal raphe nucleus
    • Varga, V., Kocsis, B., Sharp, T. (2003) Electrophysiological evidence for convergence of inputs from the medial prefrontal cortex and lateral habenula on single neurons in the dorsal raphe nucleus. Eur J Neurosci 17: 280-286.
    • (2003) Eur J Neurosci , vol.17 , pp. 280-286
    • Varga, V.1    Kocsis, B.2    Sharp, T.3
  • 44
    • 33846441234 scopus 로고    scopus 로고
    • Auto-modulation of neuroactive steroids on GABAA receptors: A novel pharmacological effect
    • Wegner, F., Rassler, C., Allgaier, C., Strecker, K., Wohlfarth, K. (2007) Auto-modulation of neuroactive steroids on GABAA receptors: a novel pharmacological effect. Neuropharmacology 52: 672-683.
    • (2007) Neuropharmacology , vol.52 , pp. 672-683
    • Wegner, F.1    Rassler, C.2    Allgaier, C.3    Strecker, K.4    Wohlfarth, K.5
  • 45
    • 0030908224 scopus 로고    scopus 로고
    • Influence of gender and brain region on neurosteroid modulation of GABA responses in rats
    • Wilson, MA, Biscardi, R. (1997) Influence of gender and brain region on neurosteroid modulation of GABA responses in rats. Life Sci 60: 1679-1691.
    • (1997) Life Sci , vol.60 , pp. 1679-1691
    • Wilson, M.A.1    Biscardi, R.2


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