Decreased TLR4 gene expression in leukemic leukocyte populations

Experimental and Molecular Pathology

Volumn 87, Issue 2, 2009, Pages 117-126

  Webb, R N ^a   Cruse, J M ^a   Lewis, R E ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Gene expression; Lymphocytic leukemia; Myeloid leukemia; qRT PCR; TLR4

Indexed keywords

TOLL LIKE RECEPTOR 4;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOSURVEILLANCE; LEUKEMIA REMISSION; LEUKEMOGENESIS; LEUKOCYTE; LYMPHATIC LEUKEMIA; MYELOID LEUKEMIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA; LEUKOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 4; TUMOR MARKERS, BIOLOGICAL;

EID: 70349235318     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2009.07.007     Document Type: Article

References (8)

1. Apetoh L., Ghiringhelli F., Tesniere A., Obeid M., Ortiz C., Criollo A., Mignot G., Maiuri M.C., Ullrich E., Saulnier P., Yang H., Amigorena S., Ryffel B., Barrat F.J., Saftig P., Levi F., Lidereau R., Nogues C., Mira J.P., Chompret A., Joulin V., Clavel-Chapelon F., Bourhis J., André F., Delaloge S., Tursz T., Kroemer G., and Zitvogel L. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat. Med. 13 (2007) 1050-1059
2. Arbour N.C., Lorenz E., Schutte B.C., Zabner J., Kline J.N., Jones M., Frees K., Watt J.L., and Schwartz D.A. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25 (2000) 187-191
3. Beutler B., Jiang Z., Georgel P., Crozat K., Croker B., Rutschmann S., Du X., and Hoebe K. Genetic analysis of host resistance: toll-like receptor signaling and immunity at large. Annu. Rev. Immunol. 24 (2006) 353-389
4. Heppner G., and Weiss D.W. High susceptibility of strain A mice to endotoxin and endotoxin-red blood cell mixtures. J. Bacteriol. 90 (1965) 696-703
5. Kiechl S., Lorenz E., Reindl M., Wiedermann C.J., Oberhollenzer F., Bonora E., Willeit J., and Schwartz D.A. Toll-like receptor 4 polymorphisms and atherogenesis. N. Engl. J. Med. 347 (2002) 185-192
6. Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol. 6 (2006) 823-835
7. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
8. Webb R.N., Cruse J.M., and Lewis R.E. Differential cytokine and Toll-like receptor expression in leukemia. Exp. Mol. Pathol. 83 (2007) 464-470