Aberrant interleukin-1 receptors in a cortisol- secreting adrenal adenoma causing Cushing's syndrome

New England Journal of Medicine

Volumn 339, Issue 1, 1998, Pages 27-31

  Willenberg, Holger S ^a,b   Stratakis, Constantine A ^b   Marx, Christian ^a   Ehrhart Bornstein, Monika ^c   Chrousos, George P ^b   Bornstein, Stefan R ^b,d  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; GASTRIC INHIBITORY POLYPEPTIDE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; VASOPRESSIN;

ADRENAL CORTEX ADENOMA; ARTICLE; CUSHING SYNDROME; DATA ANALYSIS; GENE MUTATION; HYDROCORTISONE RELEASE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; PRIORITY JOURNAL; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

ADENOMA; ADRENAL GLAND NEOPLASMS; ADRENOCORTICOTROPIC HORMONE; CUSHING SYNDROME; FEMALE; HUMANS; HYDROCORTISONE; INTERLEUKIN-1; MIDDLE AGED; POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN-1; RNA, MESSENGER;

EID: 0032474683     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199807023390105     Document Type: Article

References (20)

1. Reincke M, Mora P, Beuschlein F, Arlt W, Chrousos GP, Allolio B. Deletion of the adrenocorticotropin receptor gene in human adrenocortical tumors: implications for tumorigenesis. J Clin Endocrinol Metab 1997;82: 3054-8.
2. Lacroix A, Bolté E, Tremblay J, et al. Gastric inhibitory polypeptide-dependent cortisol hypersecretion - a new cause of Cushing's syndrome. N Engl J Med 1992;327:974-80.
3. Reznik Y, Allali-Zerah V, Chayvialle JA, et al. Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide. N Engl J Med 1992;327:981-6.
4. Lacroix A, Tremblay J, Touyz RM, et al. Abnormal adrenal and vascular responses to vasopressin mediated by a V1-vasopressin receptor in a patient with adrenocorticotropin-independent macronodular adrenal hyperplasia, Cushing's syndrome, and orthostatic hypotension. J Clin Endocrinol Metab 1997;82:2414-22.
5. Lacroix A, Tremblay J, Rousseau G, Bouvier M, Hamet P. Propranolol therapy for ectopic β-adrenergic receptors in adrenal Cushing's syndrome. N Engl J Med 1997;337:1429-34.
6. Sims JE, Gayle MA, Slack JL, et al. Interleukin 1 signaling occurs exclusively via the type I receptor. Proc Natl Acad Sci USA 1993;90:6155-9.
7. Sims JE, Giri JG, Dower SK. The two interleukin-1 receptors play different roles in IL-1 actions. Clin Immunol Immunopathol 1994;72:9-14.
8. Bornstein SR, González-Hernández JA, Ehrhart Bornstein M, Adler G, Scherbaum WA. Intimate contact of chromaffin and cortical cells within the human adrenal gland forms the cellular basis for important intraadrenal interactions. J Clin Endocrinol Metab 1994;78:225-32.
9. Tada M, Diserens AC, Desbaillets I, Jaufeerally R, Hamou MF, de Tribolet N. Production of interleukin-1 receptor antagonist by human glioblastoma cells in vitro and in vivo. J Neuroimmunol 1994;50:187-94.
10. Stratakis CA, Jenkins RB, Pras E, et al. Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex). J Clin Endocrinol Metab 1996;81:3607-14.
11. Allen RC, Zoghbi HY, Moseley AB, Rosenblatt HM, Belmont JW. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am J Hum Genet 1992;51:1229-39.
12. Päth G, Bornstein SR, Ehrhart-Bornstein M, Scherbaum WA. Interleukin-6 and the interleukin-6 receptor in the human adrenal gland: expression and effects on steroidogenesis. J Clin Endocrinol Metab 1997;82:2343-9.
13. Glasow A, Breidert M, Haidan A, Anderegg U, Kelly PA, Bornstein SR. Functional aspects of the effect of prolactin (PRL) on adrenal steroidogenesis and distribution of the PRL receptor in the human adrenal gland. J Clin Endocrinol Metab 1996;81:3103-11.
14. Beuschlein F, Reincke M, Karl M, et al. Clonal composition of human adrenocortical neoplasms. Cancer Res 1994;54:4927-32.
15. Gicquel C, Leblond-Francillard M, Bertagna X, et al. Clonal analysis of human adrenocortical carcinomas and secreting adenomas. Clin Endocrinol (Oxf) 1994;40:465-77.
16. Ehrhart-Bornstein M, Hinson JP, Bornstein SR, Scherbaum WA, Vinson GP. Intra-adrenal interactions in the regulation of adrenocortical steroidogenesis. Endocr Rev 1998;19:101-43.
17. Wegienka LC, Komarmy LE, Wuepper KD, Forsham PH. Cushing's syndrome with adrenal medullary insufficiency and adrenal autoantibodies. Lancet 1966;1:741-3.
18. Andrada JA, Murray FT, Andrada EC, Ezrin C. Cushing's syndrome and autoimmunity. Arch Pathol Lab Med 1979;103:244-6.
19. Hanley N, Williams BC, Nicol M, Bird IM, Walker SW. Interleukin-1 beta stimulates growth of adrenocortical cells in primary culture. J Mol Endocrinol 1992;8:131-6.
20. Zieleniewski W, Zieleniewski J, Stepien H. Effect of interleukin-1a, IL-1b and IL-1 receptor antibody on the proliferation and steroidogenesis of regenerating rat adrenal cortex. Exp Clin Endocrinol Diabetes 1995; 103:373-7.