Mechanism of signal transduction of the LOV2-Jα photosensor from Avena sativa

Nature Communications

Volumn 1, Issue 8, 2010, Pages

  Peter, Emanuel ^a   Dick, Bernhard ^a   Baeurle, Stephan A ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CELL PROTEIN; CYSTEINYLDOPA; FLAVINE MONONUCLEOTIDE; LIGHT OXYGEN VOLTAGE 2 JALPHA PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOPHORE; HYDROGEN BOND; MOLECULAR DYNAMICS; OAT; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

AVENA SATIVA; METAZOA;

EID: 78650058676     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1121     Document Type: Article

References (30)

1. Scott, J. D. & Pawson, T. Cell signaling in space and time: where proteins come together and when they're apart. Science 326, 1220-1224 (2009).
2. Wu, Y. I. et al. A genetically encoded photoactivable Rac controls the motility of living cells. Nature 461, 104-108 (2009).
3. Kaganman, I. 'Blue' lighting cell signaling research. Nat. Methods 6, 694-695 (2009).
4. Jones, M. A., Feeney, K. A., Kelly, S. M. & Christie, J. M. Mutational analysis of phototropin 1 provides insights into the mechanism underlying LOV2 signal transmission. J. Biol. Chem. 282, 6405-6414 (2007).
5. Kennis, J. T. M. et al. Primary reactions of the LOV2 domain of phototropin, a plant blue-light photoreceptor. Biochemistry 42, 3385-3392 (2003).
6. Alexandre, M. T. A. et al. Primary reactions of the LOV2 domain of phototropin studied with ultrafast mid-infrared spectroscopy and quantum chemistry. Biophys. J. 97, 227-237 (2009).
7. Kottke, T., Heberle, J., Hehn, D., Dick, B. & Hegemann, P. Phot-LOV1: photocycle of a blue-light receptor domain from the green alga Chlamydomonas reinhardtii. Biophys. J. 84, 1192-1201 (2003).
8. Guo, H., Kottke, T., Hegemann, P. & Dick, B. The phot LOV2 domain and its interaction with LOV1. Biophys. J. 89, 402-412 (2005).
9. Chen, E., Swartz, T. E., Bogomolni, R. A. & Kliger, D. S. A LOV story: the signaling state of the phot1 LOV2 photocycle involves chromophore-triggered protein structure relaxation, as probed by far-UV time-resolved optical rotatory dispersion spectroscopy. Biochemistry 46, 4619-4624 (2007).
10. Nozaki, D. et al. Role of Gln1029 in the photoactivation processes of the LOV2 domain in Adiantum Phytochrome3. Biochemistry 43, 8373-8379 (2004).
11. Harper, S. M., Neil, L. C. & Gardner, K. H. Structural basis of a phototropin light switch. Science 301, 1541-1544 (2003).
12. Harper, S. M., Christie, J. M. & Gardner, K. H. Disruption of the LOV-Ja helix interaction activates phototropin kinase activity. Biochemistry 43, 16184-16192 (2004).
13. Halavaty, A. S. & Moffat, K. N- and C-terminal flanking regions modulate light-induced signal transduction in the LOV2 domain of the blue light sensor phototropin 1 from Avena sativa. Biochemistry 46, 14001-14009 (2007).
14. Crosson, S. & Moffat, K. Photoexcited structure of a plant photoreceptor domain reveals a light-driven molecular switch. Plant Cell 14, 1067-1075 (2002).
15. Freddolino, P. L., Dittrich, M. & Schulten, K. Dynamic switching mechanisms in LOV1 and LOV2 domains of plant phototropins. Biophys. J. 91, 3630-3639 (2006).
16. Nash, A. I., Ko, W.- H., Harper, S. M. & Gardner, K. H. A. Conserved glutamine plays a central role in LOV domain signal transmission and its duration. Biochemistry 47, 13842-13849 (2008).
17. Iwata, T. et al. Light-induced structural changes in the LOV2 domain of Adiantum Phytochrome3 studied by low-temperature FTIR and UV-visible spectroscopy. Biochemistry 42, 8183-8191 (2003).
18. Pfeifer, A. et al. Time-resolved Fourier transform infrared study on photoadduct formation and secondary structural changes within the phototropin LOV domain. Biophys. J. 96, 1462-1470 (2009).
19. Alexandre, M. T. A., van Grondelle, R., Hellingwerf, K. J. & Kennis, J. T. M. Conformational heterogeneity and propagation of structural changes in the LOV2/Ja domain from Avena sativa phototropin 1 as recorded by temperature-dependent FTIR spectroscopy. Biophys. J. 97, 238-247 (2009).
20. Fedorov, R., Schlichting, I., Hartmann, E., Domratcheva, T., Fuhrmann, M. & Hegemann, P. Crystal structures and molecular mechanism of a light-induced signaling switch: the phot-LOV1 domain from Chlamydomonas reinhardtii. Biophys. J. 84, 2474-2482 (2003).
21. Yamamoto, A. et al. Light signal transduction pathway from flavin chromophore to the Ja helix of Arabidopsis phototropin1. Biophys. J. 96, 2771-2778 (2009).
22. Ko, W.- H., Nash, A. I. & Gardner, K. H. A LOVely view of blue light photosensing. Nat. Chem. Biol. 3, 372-374 (2007).
23. Hahn, K. & Kuhlman, B. Hold me tightly LOV. Nat. Methods 7, 595-597 (2010).
24. Strickland, D. et al. Rationally improving LOV domain-based photoswitches. Nat. Methods 7, 623-626 (2010).
25. Strickland, D., Moffat, K. & Sosnick, T. R. Light-activated DNA binding in a designed allosteric protein. Proc. Natl Acad. Sci. USA 105, 10709-10714 (2008).
26. Lindahl, E., Hess, B. & van der Spoel, D. GROMACS 3.0: a package for molecular simulation and trajectory analysis. J. Mol. Model. 7, 306-317 (2001).
27. Soares, T., Daura, X., Oostenbrink, C., Smith, L. & Gunsteren, W. Validation of the GROMOS force-field parameter set 45A3 against nuclear magnetic resonance data of hen egg lysozyme. J. Biomol. NMR 30, 407-422 (2004).
28. Todorova, N., Legge, F. S., Treutlein, H. & Yarovsky, I. Systematic comparison of empirical forcefields for molecular dynamic simulation of insulin. J. Phys. Chem. B 112, 11137-11146 (2008).
29. Frenkel, D. & Smit, B. Understanding Molecular Simulation: From Algorithms to Applications (Academic Press, 2003).
30. Neiss, C. & Saalfrank, P. Molecular dynamics simulation of the LOV2 domain from Adiantum capillus-veneris. J. Chem. Inf. Comput. Sci. 44, 1788-1793 (2004).