Predicted risks of second malignant neoplasm incidence and mortality due to secondary neutrons in a girl and boy receiving proton craniospinal irradiation

Physics in Medicine and Biology

Volumn 55, Issue 23, 2010, Pages 7067-7080

  Taddei, Phillip J ^a   Mahajan, Anita ^a   Mirkovic, Dragan ^a   Zhang, Rui ^a   Giebeler, Annelise ^a   Kornguth, David ^a   Harvey, Mark ^a   Woo, Shiao ^a   Newhauser, Wayne D ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORBED DOSE; BREAST CANCER; CRANIOSPINAL IRRADIATION; EQUIVALENT DOSE; INTERNATIONAL COMMISSION ON RADIOLOGICAL PROTECTIONS; LIVER CANCERS; LUNG CANCER; MONTE CARLO SIMULATION; NATIONAL ACADEMIES; NATIONAL RESEARCH COUNCIL; RADIOSENSITIVE ORGANS; RISK MODEL; SECONDARY NEUTRONS; SKIN CANCERS;

COMPUTER SIMULATION; DERMATOLOGY; MONTE CARLO METHODS; NEUTRONS; PROTONS; RADIOLOGY; RISK ASSESSMENT; TUMORS;

NEUTRON IRRADIATION;

PROTON;

ARTICLE; BIOLOGICAL MODEL; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; FEMALE; HUMAN; MALE; MEDULLOBLASTOMA; MONTE CARLO METHOD; MORTALITY; NEUROECTODERM TUMOR; NEUTRON; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INDUCED NEOPLASM; RISK; SEX DIFFERENCE; SKULL; SPINE;

CENTRAL NERVOUS SYSTEM NEOPLASMS; CHILD; FEMALE; HUMANS; MALE; MEDULLOBLASTOMA; MODELS, BIOLOGICAL; MONTE CARLO METHOD; NEOPLASMS, RADIATION-INDUCED; NEUROECTODERMAL TUMORS; NEUTRONS; PROTONS; RADIOTHERAPY DOSAGE; RISK; SEX FACTORS; SKULL; SPINE;

EID: 78650052263     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/55/23/S08     Document Type: Article

References (33)

1. Agosteo S, Birattari C, CaravaggioM, SilariMand Tosi G 1998 Secondary neutron and photon dose in proton therapy Radiother. Oncol. 48 293-305
2. Armstrong G T, Sklar C A, HudsonMMand Robison L L 2007 Long-term health status among survivors of childhood cancer: does sex matter? J. Clin. Oncol. 25 4477-89
3. Armstrong G T, Liu Q, Yasui Y, Neglia J P, Leisenring W, Robison L L and Mertens A C 2009 Late mortality among 5-year survivors of childhood cancer: a summary from the Childhood Cancer Survivor Study J. Clin. Oncol. 27 2328-38
4. Athar B S and Paganetti H 2009 Neutron equivalent doses and associated lifetime cancer incidence risks for head & neck and spinal proton therapy Phys. Med. Biol. 54 4907-26
5. Brenner D J, Elliston C D, Hall E J and Paganetti H 2009 Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimator Phys. Med. Biol. 54 6065-78
6. Devarhally S R, Severson R K, Chuba P, Thomas R, Bhambhani K and HamreMR 2003 Second malignant neoplasms after primary central nervous system malignancies of childhood and adolescence Pediatr. Hematol. Oncol. 20 617-25
7. Fontenot J D, Lee A K and Newhauser W D 2009 Risk of secondary malignant neoplasms from proton therapy and intensity-modulated x-ray therapy for early-stage prostate cancer Int. J. Radiat. Oncol. Biol. Phys. 74 616-22
8. Fontenot J D, Taddei P, Zheng Y, Mirkovic D, Jordan T and Newhauser W D 2008 Equivalent dose and effective dose from stray radiation during passively scattered proton radiotherapy for prostate cancer Phys. Med. Biol. 53 1677-88 (Pubitemid 351423004)
9. ICRP (International Commission on Radiological Protection) 1991 Recommendations of the International Commission on Radiological Protection: ICRP Publication 60 Ann. ICRP 21 (1-3)
10. R): ICRP Publication 92 Ann. ICRP 33 (4)
11. ICRU (International Commission on Radiation Units and Measurements) 2007 Prescribing, recording, and reporting proton-beam therapy ICRU Report 78 (Oxford: Oxford University Press)
12. Kirsch D G and Tarbell N J 2004 New technologies in radiation therapy for pediatric brain tumors: the rationale for proton radiation therapy Pediatr. Blood Cancer 42 461-4
13. Meadows A T, Friedman D L, Neglia J P, Mertens A C, Donaldson S S, Stovall M, Hammond S, Yasui Y and Inskip P D 2009 Second neoplasms in survivors of childhood cancer: findings from the Childhood Cancer Survivor Study cohort J. Clin. Oncol. 27 2356-62
14. Miralbell R, Lomax A, Cella L and Schneider U 2002 Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors Int. J. Radiat. Oncol. Biol. Phys. 54 824-9
15. Mu X, Bjork-Eriksson T, Nill S, Oelfke U, Johansson K A, Gagliardi G, Johansson L, Karlsson M and Zackrisson D B 2005 Does electron and proton therapy reduce the risk of radiation induced cancer after spinal irradiation for childhood medulloblastoma? A comparative treatment planning study Acta Oncol. 44 554-62
16. Neglia J P, Friedman D L, Yasui Y, Mertens A C, Hammond S, Stovall M, Donaldson S S, Meadows A T and Robison L L 2001 Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study J. Natl Cancer Inst. 93 618-29 (Pubitemid 32409629)
17. Newhauser W, Fontenot J, Zheng Y, Polf J, Titt U, Koch N, Zhang X and Mohan R 2007 Monte Carlo simulations for configuring and testing an analytical proton dose-calculation algorithm Phys. Med. Biol. 52 4569-84
18. Newhauser W D et al 2009a The risk of developing a second cancer after receiving craniospinal proton irradiation Phys. Med. Biol. 54 2277-91
19. NewhauserWD et al 2009b Contemporary proton therapy systems adequately protect patients from exposure to stray radiation AIP Conf. Proc. 1099 450-5
20. NewhauserWD, Giebeler A, Langen K M, Mirkovic D and Mohan R 2008a Can megavoltage computed tomography reduce proton range uncertainties in treatment plans for patients with large metal implants? Phys. Med. Biol. 53 2327-44
21. Newhauser W D, Zheng Y, Taddei P J, Mirkovic D, Fontenot J D, Giebeler A, Zhang R, Titt U and Mohan R 2008b Monte Carlo proton radiation therapy planning calculations Trans. Am. Nucl. Soc. 99 63-4
22. NRCNAS (National Research Council of the National Academy of Sciences) 2006 Health Risks From Exposure to Low Levels of Ionizing Radiation: BEIR VII-Phase 2 (Washington, DC: National Academies Press)
23. Pelowitz D B 2008 MCNPXTM User's Manual (Los Alamos, NM: Los Alamos National Laboratory) Version 2.6.0
24. Schneider U, Agosteo S, Pedroni E and Besserer J 2002 Secondary neutron dose during proton therapy using spot scanning Int. J. Radiat. Oncol. Biol. Phys. 53 244-51
25. St ClairWH, Adams J A, Bues M, Fullerton B C, La Shell S, Kooy HM, Loeffler J S and Tarbell N J 2004 Advantage of protons compared to conventional x-ray or IMRT in the treatment of a pediatric patient with medulloblastoma Int. J. Radiat. Oncol. Biol. Phys. 58 727-34
26. Taddei P J, Fontenot J D, Zheng Y, Mirkovic D, Lee A K, Titt U and Newhauser W D 2008 Reducing stray radiation dose to patients receiving passively scattered proton radiotherapy for prostate cancer Phys. Med. Biol. 53 2131-47 (Pubitemid 351605990)
27. Taddei P J, Mirkovic D, Fontenot J D, Giebeler A, Zheng Y, Kornguth D, Mohan R and Newhauser W D 2009a Stray radiation dose and second cancer risk for a pediatric patient receiving craniospinal irradiation with proton beams Phys. Med. Biol. 54 2259-75
28. Taddei P J, Mirkovic D, Fontenot J D, Giebeler A, Zheng Y, Titt U, Woo S and Newhauser W D 2009b Reducing stray radiation dose for a pediatric patient receiving proton craniospinal irradiation Nucl. Technol. 168 108-12
29. Wroe A, Clasie B, Kooy H, Flanz J, Schulte R and Rosenfeld A 2009 Out-of-field dose equivalents delivered by passively scattered therapeutic proton beams for clinically relevant field configurations Int. J. Radiat. Oncol. Biol. Phys. 73 306-13
30. Yuh G E, Loredo L N, Yonemoto L T, Bush D A, Shahnazi K, Preston W, Slater J M and Slater J D 2004 Reducing toxicity from craniospinal irradiation: using proton beams to treat medulloblastoma in young children Cancer J. 10 386-90
31. Zacharatou Jarlskog C, Lee C, Bolch W E, Xu X G and Paganetti H 2008 Assessment of organ-specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms Phys. Med. Biol. 53 693-717
32. Zacharatou Jarlskog C and Paganetti H 2008 Risk of developing second cancer from neutron dose in proton therapy as a function of field characteristics, organ, and patient age Int. J. Radiat. Oncol. Biol. Phys. 72 228-35
33. Zheng Y, Fontenot J, Taddei P, Mirkovic D and Newhauser W 2008 Monte Carlo simulations of neutron spectral fluence, radiation weighting factor and ambient dose equivalent for a passively scattered proton therapy unit Phys. Med. Biol. 53 187-201