Out-of-Field Dose Equivalents Delivered by Passively Scattered Therapeutic Proton Beams for Clinically Relevant Field Configurations

International Journal of Radiation Oncology Biology Physics

Volumn 73, Issue 1, 2009, Pages 306-313

  Wroe, Andrew ^a,b   Clasie, Ben ^c   Kooy, Hanne ^c   Flanz, Jay ^c   Schulte, Reinhard ^a   Rosenfeld, Anatoly ^b  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WOLLONGONG   (Australia)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Dose equivalent; Microdosimetry; Neutrons; Proton therapy

Indexed keywords

BANDPASS FILTERS; PROTON BEAMS; PROTONS; Q FACTOR MEASUREMENT; SILICON; SURFACE TREATMENT;

BEAM COLLIMATIONS; CLINICAL TREATMENTS; DOSE EQUIVALENT; DOSE EQUIVALENTS; EXTERNAL FIELDS; EXTERNAL-; LATERAL DISPLACEMENTS; MEDULLOBLASTOMA; MICRODOSIMETRY; OCULAR MELANOMATA; PRIMARY BEAMS; PROSTATE CANCERS; PROTON THERAPY; PROTON TREATMENTS; QUALITY FACTORS; SILICON ON INSULATORS;

PATIENT TREATMENT;

ARTICLE; DOSE CALCULATION; HUMAN; IMAGE QUALITY; MEASUREMENT; MEDULLOBLASTOMA; MELANOMA; MICRODOSIMETRY; PRIORITY JOURNAL; PROSTATE CANCER; PROTON RADIATION; QUALITATIVE ANALYSIS; RADIATION DOSE;

COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; PROTONS; RADIOMETRY; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, CONFORMAL; SCATTERING, RADIATION;

EID: 57649089544     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.09.030     Document Type: Article

References (34)

1. Hall E.J. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys 65 (2006) 1-7
2. Gottschalk B. Neutron dose in scattered and scanned proton beams: In regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1-7). Int J Radiat Oncol Biol Phys 66 (2006) 1594-1594
3. Paganetti H., Bortfeld T., and Delaney T.F. Neutron dose in proton radiation therapy: In regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1-7). Int J Radiat Oncol Biol Phys 66 (2006) 1594-1595
4. Brenner D.J., and Hall E.J. Secondary neutrons in clinical proton radiotherapy: A charged issue. Radiother Oncol 86 (2008) 165-170
5. Slater J.D. Clinical applications of proton radiation treatment at Loma Linda University: Review of a fifteen-year experience. Technol Cancer Res Treat 5 (2006) 81-89
6. Coutrakon G., Cortese J., Ghebremedhin A., et al. Microdosimetry spectra of the Loma Linda proton beam and relative biological effectiveness comparisons. Med Phys 24 (1997) 1499-1506
7. Roy S.C., and Sandison G.A. Scattered neutron dose equivalent to a fetus from proton therapy of the mother. Radiat Phys Chem 71 (2004) 997-998
8. Tayama R., Fujita Y., Tadokoro M., et al. Measurement of neutron dose distribution for a passive scattering nozzle at the Proton Medical Research Center (PMRC). Nucl Instrum Methods Phys Res Section A-Accelerators Spectrometers Detectors Assoc Equip 564 (2006) 532-536
9. Moyers M.F., Benton E.R., Ghebremedhin A., et al. Leakage and scatter radiation from a double scattering based proton beamline. Med Phys 35 (2008) 128-144
10. Mesoloras G., Sandison G.A., Stewart R.D., et al. Neutron scattered dose equivalent to a fetus from proton radiotherapy of the mother. Med Phys 33 (2006) 2479-2490
11. Wroe A., Rosenfeld A., and Schulte R. Out-of-field dose equivalents delivered by proton therapy of prostate cancer. Med Phys 34 (2007) 3449-3456
12. Agosteo S., Birattari C., Caravaggio M., et al. Secondary neutron and photon dose in proton therapy. Radiother Oncol 48 (1998) 293-305
13. Schneider U., Agosteo S., Pedroni E., et al. Secondary neutron dose during proton therapy using spot scanning. Int J Radiat Oncol Biol Phys 53 (2002) 244-251
14. Zacharatou-Jarlskog C., Lee C., Jiang H., et al. Monte Carlo simulations using whole-body pediatric and adult phantoms as virtual patients to assess secondary organ doses in proton radiation therapy. Med Phys 33 (2006) 2123-2123
15. Xu X.G., Bednarz B., and Paganetti H. A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction. Phys Med Biol 53 (2008) R193-R241
16. Polf J.C., and Newhauser W.D. Calculations of neutron dose equivalent exposures from range-modulated proton therapy beams. Phys Med Biol 50 (2005) 3859-3873
17. Zheng Y., Newhauser W., Fontenot J., et al. Monte Carlo study of neutron dose equivalent during passive scattering proton therapy. Phys Med Biol 52 (2007) 4481-4496
18. Wroe A., Rosenfeld A., Reinhard M., et al. Solid state microdosimetry with heavy ions for space applications. IEEE Trans Nucl Sci 54 (2007) 2264-2271
19. Bradley P. The development of a novel silicon microdosimeter for high LET radiation therapy (2000), University of Wollongong, Wollongong, Australia
20. Rosenfeld A.B., Bradley P.D., Cornelius I., et al. Solid state microdosimetry in hadron therapy. Radiat Protection Dosimetry 101 (2002) 431-434
21. Wroe A., Rosenfeld A., Cornelius I., et al. Silicon microdosimetry in heterogeneous materials: Simulation and experiment. IEEE Trans Nucl Sci 53 (2006) 3738-3744
22. NIST: National Institute of Standards and Technology PSTAR Database Program. Available at: http://physics.nist.gov/PhysRefData/Star/Text/PSTAR.html. Accessed January 2008.
23. ICRU Report 36: Microdosimetry, International Commission on Radiation Units & Measurements, Bethesda MD 1983.
24. Rossi H.H., and Zaider M. Microdosimetry and its applications (1996), Springer, London
25. Cornelius I. Towards silicon microdosimetry based verification of Monte Carlo calculations in hadron therapy (2003), University of Wollongong, Wollongong, Australia
26. ICRU Report 40: The quality factor in radiation protection, International Commision on Radiation Units & Measurements, Bethesda MD 1983.
27. Flanz J., Durlacher S., Goitein M., et al. Overview of the MGH Northeast-Proton-Therapy-Center plans and progress. Nuclear Instrum Methods Phys Res Section B-Beam Interactions Materials Atoms 99 (1995) 830-834
28. Newhauser W.D., Burns J., and Smith A.R. Dosimetry for ocular proton beam therapy at the Harvard Cyclotron Laboratory based on the ICRU Report 59. Med Phys 29 (2002) 1953-1961
29. Chapman P.H., Ogilvy C.S., and Butler W.E. A new stereotactic alignment system for charged-particle radiosurgery at the Harvard Cyclotron Laboratory, Boston. In: Alexander III E., Loeffler J.S., and Lunsford L.D. (Eds). Stereotactic radiosurgery (1993), McGraw-Hill, New York 105-108
30. Yan X., Titt U., Koehler A.M., et al. Measurement of neutron dose equivalent to proton therapy patients outside of the proton radiation field. Nucl Instrum Methods Phys Res Section A-Accelerators Spectrometers Detectors Assoc Equip 476 (2002) 429-434
31. Jarlskog C.Z., Lee C., Bolch W.E., et al. Assessment of organ-specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms. Phys Med Biol 53 (2008) 693-717
32. NCRP Report 38: Protection against neutron radiation, National Council on Radiation Protection and Measurements (1971), NCRP, Bethesda, MD
33. ICRP Publication 60: 1990 Recommendations of the International Commission on Radiological Protection (1991), ICRP, Oxford
34. Klein E.E., Maserang B., Wood R., et al. Peripheral doses from pediatric IMRT. Med Phys 33 (2006) 2525-2531