Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimator

Physics in Medicine and Biology

Volumn 54, Issue 20, 2009, Pages 6065-6078

  Brenner, David J ^a   Elliston, Carl D ^a   Hall, Eric J ^a   Paganetti, Harald ^b  

^a Department of Medicine   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSEMBLY DESIGNS; BEAM LINES; CANCER THERAPY; CARCINOGENIC POTENTIAL; DESIGN FEATURES; DESIGN ISSUES; HIGH-ENERGY NEUTRON; LOW DOSE; NEUTRON DOSE; OPTIMAL DESIGN; PROTON BEAM LINES; PROTON INTERACTIONS; PROTON RADIOTHERAPY; PROTON THERAPY; RELATED RISK; SCATTERING TECHNIQUES; SECONDARY NEUTRONS; SIMPLE MODIFICATIONS; WHOLE-BODY;

DESIGN; NEUTRONS; OPTICAL INSTRUMENTS; OPTIMIZATION; PROTON BEAMS; RADIOTHERAPY;

PROTONS;

ALLOY; PLASTIC;

ARTICLE; CANCER RADIOTHERAPY; COLLIMATOR; HUMAN; NEUTRON; PRIORITY JOURNAL; PROTON RADIATION; PROTON THERAPY; RADIATION DOSE; RADIATION SCATTERING;

EQUIPMENT DESIGN; HUMANS; MONTE CARLO METHOD; NEUTRONS; PARTICLE ACCELERATORS; PROTONS; RADIATION ONCOLOGY; RADIATION PROTECTION; RADIOMETRY; RADIOTHERAPY; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; SCATTERING, RADIATION;

EID: 70449087169     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/54/20/003     Document Type: Article

References (59)

1. Agosteo S, Birattari C, Caravaggio M, Silari M and Tosi G 1998 Secondary neutron and photon dose in proton therapy Radiother. Oncol. 48 293-305
2. Allison J 2007 Facilities and methods: Geant4-a simulation toolkit Nucl. Phys. News 17 20-4
3. Bagne F 1974 Effects of collimator scattering on dose for a 45 MeV betatron Phys. Med. Biol. 19 236
4. Binns P J and Hough J H 1997 Secondary dose exposures during 200 MeV proton therapy Radiat. Prot. Dosim. 70 441-4
5. Bonnett D E, Kacperek A, Sheen M A, Goodall R and Saxton T E 1993 The 62 MeV proton beam for the treatment of ocular melanoma at Clatterbridge Br. J. Radiol. 66 907-14
6. Brenner D J and Hall E J 2008 Secondary neutrons in clinical proton radiotherapy: a charged issue Radiother. Oncol. 86 165-70
7. Bues M, Newhauser W D, Titt U and Smith A R 2005 Therapeutic step and shoot proton beam spot-scanning with a multi-leaf collimator: a Monte Carlo study Radiat. Prot. Dosim. 115 164-9
8. Chadwick M B et al 2006 ENDF/B-VII.0: next generation evaluated nuclear data library for nuclear science and technology Nucl. Data Sheets 107 2931-3059
9. Chang J Y, Zhang X, Wang X, Kang Y, Riley B, Bilton S, Mohan R, Komaki R and Cox J D 2006 Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage I or Stage III non-small-cell lung cancer Int. J. Radiat. Oncol. Biol. Phys. 65 1087-96
10. Fassbender M, Shubin Y N, Lunev V P and Qaim S M 1997 Experimental studies and nuclear model calculations on the formation of radioactive products in interactions of medium energy protons with copper, zinc and brass: estimation of collimator activation in proton therapy facilities Appl. Radiat. Isot. 9 1221-30
11. Fontenot J, Taddei P, Zheng Y, Mirkovic D, Jordan T and Newhauser W 2008 Equivalent dose and effective dose from stray radiation during passively scattered proton radiotherapy for prostate cancer Phys. Med. Biol. 53 1677-88
12. Fontenot J D, Newhauser W D and Titt U 2005 Design tools for proton therapy nozzles based on the double-scattering foil technique Radiat. Prot. Dosim. 116 211-5
13. Gottschalk B 2006 Neutron dose in scattered and scanned proton beams: in regard to Eric J Hall (Int. J. Radiat. Oncol. Biol. Phys. 2006 65 1-7) Int. J. Radiat. Oncol. Biol. Phys. 66 1594
14. Hall E J 2006 Intensity-modulated radiation therapy, protons, and the risk of second cancers Int. J. Radiat. Oncol. Biol. Phys. 65 1-7
15. Hecksel D, Sandison G A, Farr J B and Edwards A C 2007 Scattered neutron dose equivalent from an active scanning proton beam delivery system Australas. Phys. Eng. Sci. Med. 30 326-30
16. Heimers A 1999 Cytogenetic analysis in human lymphocytes after exposure to simulated cosmic radiation which reflects the inflight radiation environment Int. J. Radiat. Biol. 75 691-8
17. Hendricks J S et al 2003 MCNPX version 2.5.c LANL Report LA-UR-03-2202 (Los Alamos, NM: Los Alamos National Laboratory)
18. Jiang H, Wang B, Xu X G, Suit H D and Paganetti H 2005 Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment Phys. Med. Biol. 50 4337-53
19. Kanai T, Kawachi K, Matsuzawa H and Inada T 1983 Broad beam three-dimensional irradiation for proton radiotherapy Med. Phys. 10 344-6
20. Kellerer A M, Ruhm W and Walsh L 2006 Indications of the neutron effect contribution in the solid cancer data of the A-bomb survivors Health Phys. 90 554-64
21. Koehler A M, Schneider R J and Sisterson J M 1977 Flattening of proton dose distributions for large-field radiotherapy Med. Phys. 4 297-301
22. Krasnov N N, Zatolokin B V and Konstantinov I O 1977 Some problems of calibration technique in charged particle activation analysis J. Radioanal. Chem. 39 171-7
23. Little M P 1997 Estimates of neutron relative biological effectiveness derived from the Japanese atomic bomb survivors Int. J. Radiat. Biol. 72 715-26
24. Lomax A J et al 2004 Treatment planning and verification of proton therapy using spot scanning: initial experiences Med. Phys. 31 3150-7
25. McDonough J and Tinnel B 2007 The University of Pennsylvania/Walter Reed Army Medical Center proton therapy program Technol. Cancer Res. Treat. 6 73-6
26. Meier M M, Amian W B, Goulding C A, Morgan G L and Moss C E 1992 Neutron yields from stopping-length targets for 256 MeV protons Nucl. Sci. Eng. 110 299-301
27. Mesoloras G, Sandison G A, Stewart R D, Farr J B and Hsi W C 2006 Neutron scattered dose equivalent to a fetus from proton radiotherapy to the mother Med. Phys. 33 2479-90
28. Miralbell R, Lomax A, Cella L and Schneider U 2002 Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors Int. J. Radiat. Oncol. Biol. Phys. 54 824-9
29. Moyers M F 1999 The Modern Technology of Radiation Oncology: A Compendium for Medical Physicists and Radiation Oncologists ed J Van Dyk (Madison, WI: Medical Physics Publishing) pp 823-69
30. Moyers M F, Benton E R, Ghebremedhin A and Coutrakon G 2008 Leakage and scatter radiation from a double scattering based proton beamline Med. Phys. 35 128-44
31. NCRP 1990 National Council on Radiation Protection and Measurements. The relative biological effectiveness of radiations of different quality NCRP Report 104
32. Newhauser W et al 2009 Contemporary proton therapy systems adequately protect patients from exposure to stray radiation AIP Conf. Proc. 1099 450-5
33. Nolte R, Muhlbradt K H, Meulders J P, Stephan G, Haney M and Schmid E 2005 RBE of quasi-monoenergetic 60 MeV neutron radiation for induction of dicentric chromosomes in human lymphocytes Radiat. Environ. Biophys. 44 201-9
34. Olsen D R, Bruland O S, Frykholm G and Norderhaug I N 2007 Proton therapy-a systematic review of clinical effectiveness Radiother. Oncol. 83 123-32
35. Paganetti H 2007 The impact of protons on the incidence of second malignancies in radiotherapy by Eric J Hall; 6, Suppl. 31-34 2007 Technol. Cancer Res. Treat. 6 661-2
36. Paganetti H, Jiang H, Lee S Y and Kooy H M 2004 Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility Med. Phys. 31 2107-18
37. Paganetti H, Jiang H, Parodi K, Slopsema R and Engelsman M 2008 Clinical implementation of full Monte Carlo dose calculation in proton beam therapy Phys. Med. Biol. 53 4825-53
38. Perez-Andujar A, Newhauser W D and Deluca P M 2009 Neutron production from beam-modifying devices in a modern double scattering proton therapy beam delivery system Phys. Med. Biol. 54 993-1008
39. Polf J C and Newhauser W D 2005 Calculations of neutron dose equivalent exposures from range-modulated proton therapy beams Phys. Med. Biol. 50 3859-73
40. Rayudu G V S 1964 Formation cross sections of various radionuclides from Ni, Fe, Si, Mg, O, and C for protons of energies between 130 and 400 MeV Can. J. Chem. 42 1149-54
41. Roy S C and Sandison G A 2004 Scattered neutron dose equivalent to a fetus from proton therapy of the mother Radiat. Phys. Chem. 71 997-8
42. Safai S, Bortfeld T and Engelsman M 2008 Comparison between the lateral penumbra of a collimated double-scattered beam and uncollimated scanning beam in proton radiotherapy Phys. Med. Biol. 53 1729-50
43. Schneider U, Agosteo S, Pedroni E and Besserer J 2002 Secondary neutron dose during proton therapy using spot scanning Int. J. Radiat. Oncol. Biol. Phys. 53 244-51
44. Shieldwerx 2007 SWX-207HD Self-extinguishing borated polyethylene: specifications www.shieldwerx.com/datasheets/SWX-207HD.pdf.
45. Shin D, Yoon M, Kwak J, Shin J, Lee S B, Park S Y, Park S, Kim D Y and Cho K H 2009 Secondary neutron doses for several beam configurations for proton therapy Int. J. Radiat. Oncol. Biol. Phys. 74 260-5
46. Sisterson J M 2002 Selected radiation safety issues at proton therapy facilities 12th Biennial Topical Meeting of the Radiation Protection and Shielding Division of the American Nuclear Society (Santa Fe, NM) http://gray.mgh.harvard.edu/content/dmdocuments/Janet2002.pdf
47. Slopsema R L and Kooy H M 2006 Incorporation of the aperture thickness in proton pencil-beam dose calculations Phys. Med. Biol. 51 5441-53
48. Smith A R 2009 Vision 20/20: proton therapy Med. Phys. 36 556-68
49. Taddei P J, Fontenot J D, Zheng Y, Mirkovic D, Lee A K, Titt U and Newhauser W D 2008 Reducing stray radiation dose to patients receiving passively scattered proton radiotherapy for prostate cancer Phys. Med. Biol. 53 2131-47
50. Tayama R, Fujita Y, Tadokoro M, Fujimaki H, Sakae T and Terunuma T 2006 Measurement of neutron dose distribution for a passive scattering nozzle at the Proton Medical Research Center (PMRC) Nucl. Instrum. Methods Phys. Res. A 564 532-6
51. Titarenko Y E, Batyaev V F, Zhivun V M, Lipatov K A, Mulambetov R D, Mulambetova S V, Zaitsev S L, Mashnik S G and Prael R E 2005 MENDL2 and IEAF2001 nuclide production yields databases verification in inter-medium energy range Radiat. Prot. Dosim. 115 238-41
52. van Luijk P, van t'Veld A A, Zelle H D and Schippers J M 2001 Collimator scatter and 2D dosimetry in small proton beams Phys. Med. Biol. 46 653-70
53. Wroe A, Rosenfeld A and Schulte R 2007 Out-of-field dose equivalents delivered by proton therapy of prostate cancer Med. Phys. 34 3449-56
54. Yan X, Titt U, Koehler A M and Newhauser W D 2002 Measurement of neutron dose equivalent to proton therapy patients outside of the proton radiation field Nucl. Instrum. Methods Phys. Res. A 476 429-34
55. Yonai S et al 2008 Measurement of neutron ambient dose equivalent in passive carbon-ion and proton radiotherapies Med. Phys. 35 4782-92
56. Zacharatou Jarlskog C, Lee C, Bolch W E, Xu X G and Paganetti H 2008 Assessment of organ-specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms Phys. Med. Biol. 53 693-717
57. Zacharatou Jarlskog C and Paganetti H 2008 Risk of developing second cancer from neutron dose in proton therapy as function of field characteristics, organ, and patient age Int. J. Radiat. Oncol. Biol. Phys. 72 228-35
58. Zheng Y, Newhauser W, Fontenot J, Koch N and Mohan R 2007 Monte Carlo simulations of stray neutron exposures in proton therapy J Nucl. Mater. 361 289-97
59. Ziegler J F, Biersack J P and Littmark U 2002 The Stopping and Range of Ions in Solids (New York: Pergamon Press)