Monte Carlo simulations of neutron spectral fluence, radiation weighting factor and ambient dose equivalent for a passively scattered proton therapy unit

Physics in Medicine and Biology

Volumn 53, Issue 1, 2008, Pages 187-201

  Zheng, Yuanshui ^a   Fontenot, Jonas ^a,b   Taddei, Phil ^a   Mirkovic, Dragan ^a   Newhauser, Wayne ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONTE CARLO METHODS; PATIENT TREATMENT; PROTONS; RADIATION EFFECTS; SPECTRUM ANALYSIS; TUMORS;

NEUTRON SPECTRAL FLUENCE; SCATTERED PROTON THERAPY;

NEUTRONS;

ARTICLE; CANCER PATIENT; LOW ENERGY RADIATION; MATHEMATICAL COMPUTING; MONTE CARLO METHOD; NEUTRON RADIATION; PHANTOM; PRIORITY JOURNAL; PROSTATE; PROSTATE CANCER; PROTON RADIATION; PROTON THERAPY; RADIATION ABSORPTION; RADIATION DOSE; RADIATION ENERGY; RADIATION EXPOSURE; RADIATION FIELD; RADIATION SCATTERING;

BIOPHYSICS; FAST NEUTRONS; HEALTH PHYSICS; HUMANS; MONTE CARLO METHOD; NEOPLASMS; PHANTOMS, IMAGING; PROTONS; RADIATION DOSAGE; RADIOTHERAPY, CONFORMAL; SCATTERING, RADIATION;

EID: 38049006939     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/53/1/013     Document Type: Article

References (38)

1. Agosteo S, Birattari C, Caravaggio M, Silari M and Tosi G 1998 Secondary neutron and photon dose in proton therapy Radiother. Oncol. 48 293-305
2. Bertini H W 1969 Intranuclear-cascade calculation of the secondary nucleon spectra from nucleon-nucleus interactions in the energy range 340 to 2900 MeV and comparisons with experiment Phys. Rev. 188 1711-30
3. Binns P J and Hough J H 1997 Secondary dose exposures during 200 MeV proton therapy Radiat. Prot. Dosim. 70 441-4
4. Chadwick M B et al 1999 Cross-section evaluations to 150 MeV for accelerator-driven systems and implementation in MCNPX Nucl. Sci. Eng. 131 293-328
5. Fontenot J, Newhauser W and Titt U 2005 Design tools for proton therapy nozzles based on the double-scattering technique Radiat. Prot. Dosim. 116 211-5
6. Gibbs I C, Tuamokumo N and Yock T I 2006 Role of radiation therapy in pediatric cancer Hematol. Oncol. Clin. North Am. 20 455-70
7. Gottschalk B, Koehler A, Sisterson J and Wagner M 1991 The case for passive beam spreading Proton Radiotherapy Workshop (Paul Scherrer Institute)
8. Herault J, Iborra N, Serrano B and Chauvel P 2005 Monte Carlo simulation of a protontherapy platform devoted to ocular melanoma Med. Phys. 32 910-9
9. ICRP 1991 1990 Recommendations of the International Commission on Radiological Protection Ann. ICRP 21 1-201
10. ICRP 1996 Conversion coefficients for use in radiological protection against external radiation. Adopted by the ICRP and ICRU in September 1995 Ann. ICRP 26 1-205
11. ICRP 2003 Relative biological effectiveness (RBE), quality factor (Q), and radiation weighting factor (w(R)). A report of the International Commission on Radiological Protection Ann. ICRP 33 1-117
12. Jiang H, Wang B, Xu X G, Suit H D and Paganetti H 2005 Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment Phys. Med. Biol. 50 4337-53
13. Kanai T, Kawachi K, Kumamoto Y, Ogawa H, Yamada T, Matsuzawa H and Inada T 1980 Spot scanning system for proton radiotherapy Med. Phys. 7 365-9
14. Kanai T, Kawachi K, Matsuzawa H and Inada T 1983 3-Dimensional beam scanning for proton therapy Nucl. Instrum. Method. Phys. Res. 214 491-6
15. Koehler A, Schneider R and Sisterson J 1975 Range modulators for protons and heavy ions Nucl. Instrum. Meth. 131 437-40
16. Koehler A, Schneider R and Sisterson J 1977 Flattening of proton dose distributions for large-field radiotherapy Med. Phys. 4 297-301
17. Lee C T, Bilton S D, Famiglietti R M, Riley B A, Mahajan A, Chang E L, Maor M H, Woo S Y, Cox J D and Smith A R 2005 Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques? Int. J. Radiat. Oncol. Biol. Phys. 63 362-72
18. Mesoloras G, Sandison G A, Stewart R D, Farr J B and Hsi W C 2006 Neutron scattered dose equivalent to a fetus from proton radiotherapy of the mother Med. Phys. 33 2479-90
19. Miralbell R, Lomax A, Cella L and Schneider U 2002 Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors Int. J. Radiat. Oncol. Biol. Phys. 54 824-9
20. NCRP 1971 NCRP Report 38 - Protection Against Neutron Radiation (Bethesda, MD: National Council on Radiation Protection and Measurements)
21. Newhauser W, Burns J and Smith A 2002 Dosimetry for ocular proton beam therapy at the Harvard Cyclotron Laboratory based on the ICRU Report 59 Med. Phys. 29 1953-61
22. Newhauser W, Fontenot J, Zheng Y, Polf J, Titt U, Koch N, Zhang X and Mohan R 2007 Monte Carlo simulations for configuring and testing an analytical proton dose-calculation algorithm Phys. Med. Biol. 52 4569-84
23. Newhauser W, Koch N, Hummel S, Ziegler M and Titt U 2005 Monte Carlo simulations of a nozzle for the treatment of ocular tumours with high-energy proton beams Phys. Med. Biol. 50 5229-49
24. Newhauser W D and Smith A R 2003 Scope of work and specifications for the proton treatment planning system and the associated interfaces for the Proton Therapy Center-Houston Houston, TX
25. Pedroni E, Bacher R, Blattmann H, Bohringer T, Coray A, Lomax A, Lin S, Munkel G, Scheib S and Schneider U 1995 The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization Med. Phys. 22 37-53
26. Pelowiz D B E 2005 MCNPX User's Manual Version 2.50 LA-CP-05-0369 Los Alamos National Laboratory, Los Alamos, NM
27. Polf J C and Newhauser W D 2005 Calculations of neutron dose equivalent exposures from range-modulated proton therapy beams Phys. Med. Biol. 50 3859-73
28. Polf J C, Newhauser W D and Titt U 2005 Patient neutron dose equivalent exposures outside of the proton therapy treatment field Radiat. Prot. Dosim. 115 154-8
29. Roy S C and Sandison G A 2004 Scattered neutron dose equivalent to a fetus from proton therapy of the mother Radiat. Phys. Chem. 71 997-8
30. Schneider U, Agosteo S, Pedroni E and Besserer J 2002 Secondary neutron dose during proton therapy using spot scanning Int. J. Radiat. Oncol. Biol. Phys. 53 244-51
31. Tayama R, Fujita Y, Tadokoro M, Fujimaki H, Sakae T and Terunuma T 2006 Measurement of neutron dose distribution for a passive scattering nozzle at the Proton Medical Research Center (PMRC) Nucl. Instrum. Method Phys. Res. A 564 532-6
32. Tilly N, Grusell E, Kimstrand P, Lorin S, Gajewski K, Pettersson M, Backlund A and Glimelius B 2007 Development and verification of the pulsed scanned proton beam at The Svedberg Laboratory in Uppsala Phys. Med. Biol. 52 2741-54
33. Wroe A J, Rosenfeld A B and Schulte R 2007 Out-of-field dose equivalents delivered by proton therapy of prostate cancer Med. Phys. 34 3449-56
34. Yan X, Titt U, Koehler A M and Newhauser W D 2002 Measurement of neutron dose equivalent to proton therapy patients outside of the proton radiation field Nucl. Instrum. Methods Phys. Res. A 476 429-34
35. Yariv Y and Fraenkel Z 1979 Intranuclear cascade calculation of high-energy heavy-ion interactions Phys. Rev. C 20 2227-43
36. Zheng Y, Newhauser W, Fontenot J, Taddei P and Mohan R 2007a Monte Carlo study of neutron dose equivalent during passive scattering proton therapy Phys. Med. Biol. 52 4481-96
37. Zheng Y, Newhauser W D, Fontenot J D and Koch N C 2006 Development of a code system to automatically generate MCNPX input files for proton therapy simulations American Nuclear Sociey's 14th Biennial Topical Meeting of the Radiation Protection and Shielding Division (Carlsbad, NM)
38. Zheng Y S, Newhauser W, Fontenot J, Koch N and Mohan R 2007b Monte Carlo simulations of stray neutron radiation exposures in proton therapy J. Nucl. Mater. 361 289-97