The impact of cyclooxygenase inhibition on duodenal motility and mucosal alkaline secretion in anaesthetized rats

Acta Physiologica

Volumn 201, Issue 1, 2011, Pages 179-192

  Nylander, O ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Bicarbonate secretion; Fluid flux; Indomethacin; Mucosal permeability; Parecoxib; Postoperative ileus

Indexed keywords

CYCLOOXYGENASE 2; LIDOCAINE; SODIUM CHLORIDE;

ALKALINITY; ANIMAL EXPERIMENT; CONTROLLED STUDY; DUODENUM MOTILITY; DUODENUM MUCOSA; ENZYME INHIBITION; MALE; MUSCLE HYPOTONIA; NONHUMAN; OSMOLALITY; PRIORITY JOURNAL; RAT; REVIEW;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BICARBONATES; CHLORIDES; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DUODENUM; EPOPROSTENOL; GASTROINTESTINAL MOTILITY; HUMANS; INDOMETHACIN; MALE; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 78650038801     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2010.02196.x     Document Type: Review

References (82)

1. Allen, A. & Flemström, G. 2005. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol (Cell Physiol) 288, C1-C19.
2. Axelsson, L.G., Wallin, B., Gillberg, P.G., Sjöberg, B., Söderberg, C. & Hellström, P.M. 2003. Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats. Eur J Pharmacol 467, 211-218.
3. Bauer, A.J. & Boeckxstaens, G.E. 2004. Mechanisms of postoperative ileus. Neurogastroenterol Motil 16(Suppl 2), 54-60.
4. Boeckxstaens, G.E. & De Jonge, W.J. 2009. Neuroimmune mechanisms in postoperative ileus. Gut 58, 1300-1311.
5. Bouras, E.P., Burton, D.D., Camilleri, M., Stephens, D.A. & Thomforde, G.M. 2004. Effect of cyclooxygenase-2 inhibitors on gastric emptying and small intestine transit in humans. Neurogastroenterol Motil 16, 729-735.
6. Bueno, L., Ferre, J.P. & Ruckebusch, Y. 1978. Effects of anesthesia and surgical procedures in intestinal myoelectric activity in rats. Am J Dig Dis 23, 690-695.
7. Cao, Y. & Prescott, S.M. 2002. Many action of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol 190, 279-286.
8. Catterall, W. & Mackie, K. 1996. Local anesthetics. In: J.G. Hardman, L.E. Limbird, P.B. Molinoff & R.W. Ruddon (eds) Goodman & Gilman's. The Pharmacological Basis of Therapeutics, pp. 331-347.McGraw-Hill, New York.
9. Chan, C.C., Boyce, S., Brideau, C., Charleson, S., Cromlish, W., Ethier, D., Evans, J., Ford-Hutchinson, A.W., Forrest, M.J., Gauthier, J.Y. et al. 1999. Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. Pharmacol Exp Ther 290, 551-560.
10. 2-adrenergic receptors: yohimbine and p-aminoclonidine binding relative to ion transport. Am J Physiol Gastrointest Liver Physiol 244, G76-G82.
11. Fändriks, L., Jönson, C., Hamlet, A., Danielsen, N. & Johansson, B.R. 1995. Sympatho-adrenergic inhibition of basal and acid-induced changes in duodenal motility, mucosal net fluid and alkaline secretion in the anaesthetised cat. Acta Physiol Scand 153, 211-219.
12. Fleckenstein, P. 1978. Migrating electrical spike activity in the fasting human small intestine. Am J Dig Dis 23, 769-775.
13. - transport in isolated proximal bullfrog duodenum by prostaglandins. Am J Physiol Gastrointest Liver Physiol 239, G198-G204.
14. Flemström, G. 1987. Gastric and duodenal mucosal bicarbonate secretion. In: L.R. Johnson (ed.) Physiology of the Gastrointestinal Tract, 2nd edn, pp. 1011-1029. Raven Press, New York.
15. Flemström, G. & Kivilaakso, E. 1983. Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkaline secretion. Gastroenterology 84, 787-794.
16. - transport by mammalian duodenum in vivo. Am J Physiol Gastrointest Liver Physiol 243, G348-G358.
17. Fornai, M., Antonioli, L., Colucci, R., Bernardi, N., Ghisu, N., Tuccori, M., De Giorgio, R., Del Tacca, M. & Blandizzi, C. 2010. Emerging role of cyclooxygenase isoform in the control of gastrointestinal neuromuscular functions. Pharmacol Ther 125, 62-78.
18. Furness, J.B. 2006. The Enteric Nervous System. Wiley-Blackwell, Oxford, UK.
19. 2. Am J Physiol Gastrointest Liver Physiol 288, G557-G563.
20. Greenwood, B. & Davison, J.S. 1987. The relationship between gastrointestinal motility and secretion. Am J Physiol Gastrointest Liver Physiol 252, G1-G7.
21. Hällgren, A., Flemström, G., Sababi, M. & Nylander, O. 1995. Effects of nitric oxide inhibition on duodenal function in rat: involvement of neural mechanisms. Am J Physiol Gastrointest Liver Physiol 269, G246-G254.
22. Hasler, W.L. 2006. Small intestinal motility. In: L.R. Johnson (ed.) Physiology of the Gastrointestinal Tract, 4th edn, pp. 935-964. Elsevier Academic Press, Burlington, MA.
23. Haworth, R., Oakley, K., McCormack, N. & Pilling, A. 2005. Differential expression of COX-1 and COX-2 in the gastrointestinal tract of the rat. Toxicol Pathol 33, 239-245.
24. Hirata, T., Ukawa, H., Kitamura, M. & Takeuchi, K. 1997. Effects of selective cyclooxygenase inhibitors on alkaline secretory and mucosal ulcerogenic responses in rat duodenum. Life Sci 61, 1603-1611.
25. Holm, M., Johansson, B., Pettersson, A. & Fändriks, L. 1998. Carbon dioxide mediates duodenal mucosal alkaline secretion in response to luminal acidity in the anesthetized rat. Gastroenterology 115, 680-685.
26. Ito, S., Okuda-Ashitaka, E. & Minami, T. 2001. Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin. Neurosci Res 41, 299-332.
27. 2-adrenoceptors. Acta Physiol Scand 130, 387-391.
28. Josephs, M.D., Cheng, G., Ksontini, R., Moldawer, L.L. & Hocking, M.P. 1999. Products of cyclooxygenase-2 catalysis regulate postoperative bowel motility. J Surg Res 86, 50-54.
29. Kalff, J.C., Turler, A., Schwarz, N.T., Schraut, W.H., Lee, K.K., Tweardy, D.J., Billiar, T.R., Simmons, R.L. & Bauer, A.J. 2003. Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg 237, 301-315.
30. Kargman, S., Charleson, S., Cartwright, M., Frank, J., Riendeau, D., Mancini, J., Evans, J. & O'Neill, G. 1996. Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. Gastroenterology 111, 445-454.
31. Kaunitz, J.D. & Akiba, Y. 2006. Review article: duodenal bicarbonate - mucosal protection, luminal chemosensing and acid-base balance. Aliment Pharmacol Ther 24, 169-176.
32. Konturek, S.J. & Thor, P. 1986. Relation between duodenal alkaline secretion and motility in fasted and sham-fed dogs. Am J Physiol Gastrointest Liver Physiol 251, G591-G596.
33. Korolkiewicz, R.P., Udja, M., Dabkowski, J., Ruczynski, J., Rekowski, P. & Petrusewicz, J. 2003. Differential salutary effects of nonselective and selective COX-2 inhibitors in postoperative ileus in rats. J Surg Res 109, 161-169.
34. Kreiss, C., Birder, L.A., Kiss, S., VanBibber, M.M. & Bauer, A.J. 2003. COX-2 dependent inflammation increases spinal Fos expression during rodent postoperative ileus. Gut 52, 527-534.
35. Lomax, A.E., Sharkey, K.A. & Furness, J.B. 2010. The participation of the sympathetic innervation of the gastrointestinal tract in disease states. Neurogastroenterol Motil 22, 7-18.
36. Maubach, K.A. & Grundy, D. 1999. The role of prostaglandins in the bradykinin-induced activation of serosal afferents of the rat jejunum in vitro. J Physiol 515, 277-285.
37. Mellander, A., Abrahamsson, H. & Sjövall, H. 1993. Mechanisms behind cyclic changes in duodenal fluid in the fasting state. Acta Physiol Scand 149, 475-482.
38. Menger, M.D. & Vollmar, B. 2004. Surgical trauma: hyperinflammation versus immunosuppression. Langenbecks Arch Surg 389, 475-484.
39. Montrose, M.H., Akiba, Y., Takeuchi, K. & Kaunitz, J.D. 2006. Gastroduodenal mucosal defence. In: L.R. Johnson (ed.) Physiology of the Gastrointestinal Tract, 4th edn, pp. 1259-1291. Elsevier Academic Press, Burlington, MA.
40. Mueller, M.H., Glatzle, J., Kapitoglou, D., Kasparek, M.S., Grundy, D. & Kreis, M.E. 2008. Differential sensitization of afferent neuronal pathways during postoperative ileus in the mouse jejunum. Ann Surg 247, 791-802.
41. - secretion in the rat in vivo. Acta Physiol Scand 126, 433-441.
42. Nylander, O. & Pihl, L. 2006. Luminal hypotonicity increases duodenal mucosal permeability by a mechanism involving 5-hydroxytryptamine. Acta Physiol 186, 45-58.
43. Nylander, O. & Sjöblom, M. 2007. Modulation of mucosal permeability by vasoactive intestinal peptide or lidocaine affects the adjustment of luminal hypotonicity in rat duodenum. Acta Physiol 189, 325-335.
44. Nylander, O., Kvietys, P. & Granger, D.N. 1989. Effects of hydrochloric acid on duodenal and jejunal mucosal permeability in the rat. Am J Physiol Gastrointest Liver Physiol 257, G653-G660.
45. Nylander, O., Andersson, H., Wilander, E. & Sababi, M. 1995. Prostaglandins reduce hydrochloric-acid induced increase in duodenal mucosal permeability by a mechanism not related to stimulation of alkaline secretion. Acta Physiol Scand 153, 365-374.
46. Nylander, O., Hällgren, A. & Sababi, M. 2001. COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum. Am J Physiol Gastrointest Liver Physiol 281, G1169-G1178.
47. Nylander, O., Pihl, L. & Perry, M. 2003. The hypotonicity-induced increase in duodenal mucosal permeability facilitates adjustment of luminal osmolality. Am J Physiol Gastrointest Liver Physiol 285, G360-G370.
48. Padi, S.S.V., Jain, N.K., Singh, S. & Kulkarni, S.K. 2004. Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. Eur J Pharmacol 491, 69-76.
49. Pairet, M. & Ruckebusch, Y. 1989. On the relevance of non-steroidal anti-inflammatory drugs in the prevention of paralytic ileus in rodents. J Pharm Pharmacol 41, 757-761.
50. Pihl, L. & Nylander, O. 2006. Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery. Acta Physiol 186, 279-290.
51. Pihl, L., Wilander, E. & Nylander, O. 2008. Comparative study of the effect of luminal hypotonicity on mucosal permeability in rat upper gastrointestinal tract. Acta Physiol 193, 67-78.
52. -. Acta Physiol 200, 181-191.
53. Rajakariar, R., Yaqoob, M.M. & Gilroy, D.W. 2006. COX-2 in inflammation and resolution. Mol Interv 6, 199-207.
54. Read, N.W., Smallwood, R.H., Levin, R.J., Holdsworth, C.D. & Brown, B.H. 1977. Relationship between changes in intraluminal pressure and transmural potential difference in the human and caine jejunum in vivo. Gut 18, 141-151.
55. Ruckebusch, M. & Fioramonti, J. 1975. Electrical spiking activity and propulsion in small intestine in fed and fasted rats. Gastroenterology 68, 1500-1508.
56. Sababi, M. & Nylander, O. 1994. Elevation of intraluminal pressure and cyclooxygenase inhibitors increases duodenal alkaline secretion. Am J Physiol Gastrointest Liver Physiol 266, G22-G30.
57. Sababi, M. & Nylander, O. 1996. Comparative study of the effects of nitric oxide synthase and cyclooxygenase inhibition on duodenal functions in rats anaesthetised with inactin, urethane or α-chloralose. Acta Physiol Scand 158, 45-52.
58. Sababi, M., Hällgren, A. & Nylander, O. 1996. Interaction between prostanoids, NO, and VIP in modulation of duodenal alkaline secretion and motility. Am J Physiol Gastrointest Liver Physiol 271, G582-G590.
59. Sanders, K.M. 1984. Evidence that prostaglandins are local regulatory agents in canine ileal circular muscle. Am J Physiol Gastrointest Liver Physiol 9, G361-G371.
60. Schwarz, N.T., Kalff, J.C., Türler, A., Engel, B.M., Watkins, S.C., Billiar, T.R. & Bauer, A.J. 2001. Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus. Gastroenterology 121, 1354-1371.
61. Schwarz, N.T., Kalff, J.C., Türler, A., Speidel, N., Grandis, J.R., Billiar, T.R. & Bauer, A.J. 2004. Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility. Gastroenterology 126, 159-169.
62. Selling, J.A., Hogan, D.L., Aly, A., Koss, M.A. & Isenberg, J.I. 1987. Indomethacin inhibits duodenal mucosal bicarbonate secretion and endogenous prostaglandin E2 output in human subjects. Ann Intern Med 106, 368-371.
63. Sigthorsson, G., Simpson, R.J., Walley, M., Anthony, A., Foster, R., Hotz-Behoftsitz, C., Palizban, A., Pombo, J., Watts, J., Morham, S.G. & Bjarnason, I. 2002. COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice. Gastroenterology 122, 1913-1923.
64. - exchange in the villous epithelium of intact murine duodenum. Am J Physiol Gastrointest Liver Physiol 288, G1241-G1251.
65. --exchanger in the upper villous epithelium of the murine duodenum. Am J Physiol Gastrointest Liver Physiol 294, G1079-G1088.
66. --transport in vivo: influence of prostaglandins. Am J Physiol Gastrointest Liver Physiol 245, G751-G759.
67. - secretion in conscious rat. Dig Dis Sci 39, 2134-2142.
68. Smith, C.J., Zhang, Y., Koboldt, C.M., Muhammad, J., Zweifel, B.S., Shaffer, A., Talley, J.J., Masferrer, J.L., Seibert, K. & Isakson, P.C. 1998. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci 95, 13313-13318.
69. - secretion. Am J Physiol Gastrointest Liver Physiol 285, G887-G897.
70. Szurszewski, J.H. 1969. A migrating electric complex of the canine small intestine. Am J Physiol 217, 1757-1763.
71. Takeuchi, K., Nobuhara, Y., Tanaka, H., Nishiwaki, H. & Okabe, S. 1988. Effects of hemorrhagic shock on alkaline secretion and mucosal tolerance to acid in rat duodenum. A comparative study with indomethacin. Dig Dis Sci 33, 1409-1417.
72. Takeuchi, K., Ukawa, H., Furukawa, O., Kawauchi, S., Araki, H., Sugimoto, Y., Ishikawa, A., Ushikubi, F. & Narumiya, S. 1999. Prostaglandin E receptor subtypes involved in stimulation of gastroduodenal bicarbonate secretion in rats and mice. J Physiol Pharmacol 50, 155-167.
73. Takeuchi, K., Kagawa, S., Mimaki, H., Aoi, M. & Kawauchi, S. 2002. COX and NOS isoforms involved in acid-induced duodenal bicarbonate secretion in rats. Dig Dis Sci 47, 2116-2124.
74. Tanaka, A., Hase, S., Miyazawa, T., Ohno, R. & Takeuchi, K. 2002. Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroid anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events. J Pharmacol Exp Ther 303, 1248-1254.
75. Thollander, M., Hellström, P.M. & Svensson, T.H. 1989. Suppression of small intestinal motility and morphine withdrawal diarrhoea by clonidine: peripheral site of action. Acta Physiol Scand 137, 385-392.
76. Thor, P., Konturek, J.W., Konturek, J.S. & Anderson, J.H. 1985. Role of prostaglandins in control of intestinal motility. Am J Physiol Gastrointest Liver Physiol 248, G353-G359.
77. - secretion. Gastroenterology 130, 349-358.
78. Vane, J.R., Bakhla, Y.S. & Botting, R.M. 1998. Cyclooxygenase 1 and 2. Annu Rev Pharmacol Toxicol 38, 97-120.
79. Wallace, J.L. 2008. Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? Physiol Rev 88, 1547-1565.
80. Warner, T.D. & Mitchell, J.A. 2004. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB J 18, 790-804.
81. Yaksh, T.L., Dirig, D.M., Conway, C.M., Svensson, C., Luo, Z.D. & Isakson, P.C. 2001. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. J Neurosci 21, 5847-5853.
82. Zha, S., Yegnasubramanian, V., Nelson, W.G., Isaacs, W.B. & De Marzo, A.M. 2004. Cyclooxygenases in cancer: progress and perspective. Cancer Lett 215, 1-20.