메뉴 건너뛰기




Volumn 174, Issue 6 A, 2010, Pages 691-702

Analysis of flow cytometry DNA damage response protein activation kinetics after exposure to X rays and high-energy iron nuclei

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; GAMMA H2AX PROTEIN; HISTONE H2AX; IRON NUCLEI; NUCLEIC ACID; UNCLASSIFIED DRUG;

EID: 78650030231     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2204.1     Document Type: Article
Times cited : (13)

References (47)
  • 2
    • 33645991783 scopus 로고    scopus 로고
    • Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings
    • F. A. Cucinotta and M. Durante, Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet Oncol. 7, 431-435 (2006).
    • (2006) Lancet Oncol. , vol.7 , pp. 431-435
    • Cucinotta, F.A.1    Durante, M.2
  • 3
    • 44349143334 scopus 로고    scopus 로고
    • Heavy ion carcinogenesis and human space exploration
    • M. Durante and F. A. Cucinotta, Heavy ion carcinogenesis and human space exploration. Nat. Rev. Cancer 8, 465-472 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 465-472
    • Durante, M.1    Cucinotta, F.A.2
  • 4
    • 0027976408 scopus 로고
    • Initial events in the cellular effects of ionising radiation: Clustered damage in DNA
    • D. T. Goodhead, Initial events in the cellular effects of ionising radiation: clustered damage in DNA. Int. J. Radiat. Biol. 65, 7-17 (1994).
    • (1994) Int. J. Radiat. Biol. , vol.65 , pp. 7-17
    • Goodhead, D.T.1
  • 5
    • 0034074917 scopus 로고    scopus 로고
    • Model of the radial distribution of energy imparted in nanometer volumes from HZE particles
    • F. A. Cucinotta, H. Nikjoo and D. T. Goodhead, Model of the radial distribution of energy imparted in nanometer volumes from HZE particles. Radiat. Res. 153, 459-468 (2000).
    • (2000) Radiat. Res. , vol.153 , pp. 459-468
    • Cucinotta, F.A.1    Nikjoo, H.2    Goodhead, D.T.3
  • 6
    • 57049168221 scopus 로고    scopus 로고
    • Stochastic properties of radiation induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci
    • A. Ponomarev, S. Costes and F. A. Cucinotta, Stochastic properties of radiation induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci. Int. J. Radiat. Biol. 84, 916-929 (2008).
    • (2008) Int. J. Radiat. Biol. , vol.84 , pp. 916-929
    • Ponomarev, A.1    Costes, S.2    Cucinotta, F.A.3
  • 8
    • 0037981413 scopus 로고    scopus 로고
    • Cell cycle-dependent expression of phosphorylated histone H2AX: Reduced expression in unirradiated but not X-irradiated G1-phase cells
    • S. H. MacPhail, J. P. Banath, Y. Yu, E. Chu and P. L. Olive, Cell cycle-dependent expression of phosphorylated histone H2AX: Reduced expression in unirradiated but not X-irradiated G1-phase cells. Radiat. Res. 159, 759-767 (2003).
    • (2003) Radiat. Res. , vol.159 , pp. 759-767
    • MacPhail, S.H.1    Banath, J.P.2    Yu, Y.3    Chu, E.4    Olive, P.L.5
  • 9
    • 0036173143 scopus 로고    scopus 로고
    • Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry
    • O. D. Perez and G. P. Nolan, Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry. Nat. Biotechnol. 20, 155-162 (2002).
    • (2002) Nat. Biotechnol. , vol.20 , pp. 155-162
    • Perez, O.D.1    Nolan, G.P.2
  • 10
    • 51649084055 scopus 로고    scopus 로고
    • Specific ATM-mediated phosphorylation dependent on radiation quality
    • M. K. Whalen, S. K. Gurai, H. Zahed-Kargaran and J. M. Pluth, Specific ATM-mediated phosphorylation dependent on radiation quality. Radiat. Res. 170, 353-364 (2008).
    • (2008) Radiat. Res. , vol.170 , pp. 353-364
    • Whalen, M.K.1    Gurai, S.K.2    Zahed-Kargaran, H.3    Pluth, J.M.4
  • 11
    • 23044435948 scopus 로고    scopus 로고
    • Cellular mechanisms for low-dose ionizing radiation-induced perturbations of the breast tissue microenvironment
    • K. K. Tsai, E. Y. Chuang, J. B. Little and Z. M. Yuan, Cellular mechanisms for low-dose ionizing radiation-induced perturbations of the breast tissue microenvironment. Cancer Res. 65, 6734-6744 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 6734-6744
    • Tsai, K.K.1    Chuang, E.Y.2    Little, J.B.3    Yuan, Z.M.4
  • 12
    • 0018428545 scopus 로고
    • Mutation and inactivation of cultured mammalian cells exposed to beams of accelerated heavy ions. III. Human diploid fibroblasts
    • R. Cox and W. K. Masson, Mutation and inactivation of cultured mammalian cells exposed to beams of accelerated heavy ions. III. Human diploid fibroblasts. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 36. 149-160 (1979).
    • (1979) Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. , vol.36 , pp. 149-160
    • Cox, R.1    Masson, W.K.2
  • 13
    • 0034612308 scopus 로고    scopus 로고
    • The nonhomologous endjoining pathway of DNA repair is required for genomic instability and the suppression of translocations
    • D. O. Ferguson, J. M. Sekiguchi, S. Chang, K. M. Frank, Y. Gao, R. A. DePinho and F. W. Alt, The nonhomologous endjoining pathway of DNA repair is required for genomic instability and the suppression of translocations. Proc. Natl. Acad. Sci. USA 97, 6630-6633 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6630-6633
    • Ferguson, D.O.1    Sekiguchi, J.M.2    Chang, S.3    Frank, K.M.4    Gao, Y.5    DePinho, R.A.6    Alt, F.W.7
  • 14
    • 28544432416 scopus 로고    scopus 로고
    • Post-replicative joining of DNA double strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts
    • M. Martin, A. Genesca, L. Lutre, I. Jaco, G. E. Taccioli, J. Egozcue, M. A. Blasco, G. Iliakis and L. Tusell, Post-replicative joining of DNA double strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts. Cancer Res. 65, 10223-10232 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 10223-10232
    • Martin, M.1    Genesca, A.2    Lutre, L.3    Jaco, I.4    Taccioli, G.E.5    Egozcue, J.6    Blasco, M.A.7    Iliakis, G.8    Tusell, L.9
  • 15
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimmer dissociation
    • C. J. Bakkenist and M. B. Kastan, DNA damage activates ATM through intermolecular autophosphorylation and dimmer dissociation. Nature 421, 499-506 (2003).
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 16
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-strand breaks induce histone H2AX phosphorylation on serine 139
    • E. P. Rogakou, D. R. Pilch, A. H. Orr, V. S. Ivanova and W. M. Bonner, DNA double-strand breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 17
    • 84881150667 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • E. P. Rogakou, C. Boon and W. M. Bonner, Megabase chromatin domains involved in DNA double-strand breaks in vivo. Curr. Opin. Genet. Dev. 12, 162-169 (2002).
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 162-169
    • Rogakou, E.P.1    Boon, C.2    Bonner, W.M.3
  • 18
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • T. T. Paull, E. P. Rogakou, V. Yamazaki, C. U. Kirchgessner, M. Gellert and W. M. Bonner, A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol. 10, 886-895 (2000).
    • (2000) Curr Biol. , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 19
    • 0036789173 scopus 로고    scopus 로고
    • Quantitative detection of 125IdU-induced DNA doublestrand breaks with γ-H2AX antibody
    • O. A. Sedelnikova, E. P. Rogakou, I. G. Panyutin and W. M. Bonner, Quantitative detection of 125IdU-induced DNA doublestrand breaks with γ-H2AX antibody. Radiat. Res. 158, 486-492 (2002).
    • (2002) Radiat. Res. , vol.158 , pp. 486-492
    • Sedelnikova, O.A.1    Rogakou, E.P.2    Panyutin, I.G.3    Bonner, W.M.4
  • 20
    • 0037884963 scopus 로고    scopus 로고
    • Evidence of lack of DNA double-strand break repair in human cells exposed to very low Xray doses
    • K. Rothkamm and M. Lobrich, Evidence of lack of DNA double-strand break repair in human cells exposed to very low Xray doses. Proc. Natl. Acad. Sci. USA 100, 5057-5062 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Lobrich, M.2
  • 21
    • 0034725037 scopus 로고    scopus 로고
    • Stability of the ATF2 transcription factor is regulated by phosphorylation and dephosphorylation
    • S. Y. Fuchs, I. Tappin and Z. Ronai, Stability of the ATF2 transcription factor is regulated by phosphorylation and dephosphorylation. J. Biol. Chem. 275, 12560-12564 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 12560-12564
    • Fuchs, S.Y.1    Tappin, I.2    Ronai, Z.3
  • 22
    • 0033786115 scopus 로고    scopus 로고
    • The transcription factor ATF-2 inhibits extracellular signal regulated kinase expression and proliferation of human cancer cells
    • D. L. Crowe and B. Shemirani, The transcription factor ATF-2 inhibits extracellular signal regulated kinase expression and proliferation of human cancer cells. Anticancer Res. 20, 2945-2949 (2000).
    • (2000) Anticancer Res. , vol.20 , pp. 2945-2949
    • Crowe, D.L.1    Shemirani, B.2
  • 23
    • 19444363740 scopus 로고    scopus 로고
    • ATM-dependent phosphorylation of ATF2 is required for the DNA damage response
    • A. Bhoumik, S. Takahashi, W. Breitweiser, Y. Shiloh, N. Jones and Z. Ronai, ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol. Cell 18, 577-587 (2005).
    • (2005) Mol. Cell , vol.18 , pp. 577-587
    • Bhoumik, A.1    Takahashi, S.2    Breitweiser, W.3    Shiloh, Y.4    Jones, N.5    Ronai, Z.6
  • 24
    • 0036500555 scopus 로고    scopus 로고
    • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
    • S. T. Kim, B. Xu and M. B. Kastan, Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16, 560-570 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 560-570
    • Kim, S.T.1    Xu, B.2    Kastan, M.B.3
  • 25
    • 2942687831 scopus 로고    scopus 로고
    • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    • R. Kitagawa, C. J. Bakkenist, P. J. McKinnon and M. B. Kastan, Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 18, 1423-1438 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 1423-1438
    • Kitagawa, R.1    Bakkenist, C.J.2    McKinnon, P.J.3    Kastan, M.B.4
  • 26
    • 4444292641 scopus 로고    scopus 로고
    • SMC1 coordinates DNA double-strand break repair pathways
    • P. Schaer, M. Faesi and R. Jessberger, SMC1 coordinates DNA double-strand break repair pathways. Nucleic Acids Res. 32, 3921-3929 (2004).
    • (2004) Nucleic Acids Res. , vol.32 , pp. 3921-3929
    • Schaer, P.1    Faesi, M.2    Jessberger, R.3
  • 27
    • 0017191339 scopus 로고
    • Method for the quantitative evaluation of data from flow microfluorometry
    • J. Fried, Method for the quantitative evaluation of data from flow microfluorometry. Comp. Biomed. Res. 9, 263-276 (1976).
    • (1976) Comp. Biomed. Res. , vol.9 , pp. 263-276
    • Fried, J.1
  • 28
    • 0001406104 scopus 로고    scopus 로고
    • Statistical considerations in DNA flow cytometry
    • L. T. Eudey, Statistical considerations in DNA flow cytometry. Stat. Sci. 11, 320-334 (1996).
    • (1996) Stat. Sci. , vol.11 , pp. 320-334
    • Eudey, L.T.1
  • 29
    • 78650034909 scopus 로고    scopus 로고
    • MCLUST Version 3 for R: Normal Mixture Modeling and Model-Based Clustering Technical Report No. 504, Department of Statistics, University of Washington, Seattle. [Available online at]
    • C. Fraley and A. Raftery, MCLUST Version 3 for R: Normal Mixture Modeling and Model-Based Clustering. Technical Report No. 504, Department of Statistics, University of Washington, Seattle, 2008. [Available online at http://www.stat. washington.edu/fraley/mclust]
    • (2008)
    • Fraley, C.1    Raftery, A.2
  • 31
    • 47249123075 scopus 로고    scopus 로고
    • The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: A simulation study
    • J. O. Friedrich, K. J. Neill, A. Adhikari and J. Beyene, The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: A simulation study. BMC Med. Res. Method. 8, 32 (2008).
    • (2008) BMC Med. Res. Method. , vol.8 , pp. 32
    • Friedrich, J.O.1    Neill, K.J.2    Adhikari, A.3    Beyene, J.4
  • 32
    • 0000120766 scopus 로고
    • Estimating the dimension of a model
    • G. Schwarz, Estimating the dimension of a model. Ann. Stat. 6, 461-464 (1978).
    • (1978) Ann. Stat. , vol.6 , pp. 461-464
    • Schwarz, G.1
  • 33
    • 0036682280 scopus 로고    scopus 로고
    • Clustered DNA damage induced by c-radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites
    • M. Gulston, J. Fulford, T. Jenner, C. de Lara and P. O'Neill, Clustered DNA damage induced by c-radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. Nucleic Acids Res. 30, 3464-3472 (2002).
    • (2002) Nucleic Acids Res. , vol.30 , pp. 3464-3472
    • Gulston, M.1    Fulford, J.2    Jenner, T.3    De Lara, C.4    O'Neill, P.5
  • 34
    • 33646761276 scopus 로고    scopus 로고
    • Chromatin loops are responsible for higher counts of small DNA fragments induced by high-LET radiation, while chromosomal domains do not affect the fragment sizes
    • A. Ponomarev and F. A. Cucinotta, Chromatin loops are responsible for higher counts of small DNA fragments induced by high-LET radiation, while chromosomal domains do not affect the fragment sizes. Int. J. Radiat. Biol. 82, 293-305 (2006).
    • (2006) Int. J. Radiat. Biol. , vol.82 , pp. 293-305
    • Ponomarev, A.1    Cucinotta, F.A.2
  • 35
    • 25444502873 scopus 로고    scopus 로고
    • Immunofluorescent detection of DNA double-strand breaks induced by high-LET radiation
    • N. Desai, E. Davis, P. O'Neill, M. Durante, F. A. Cucinotta and H. Wu, Immunofluorescent detection of DNA double-strand breaks induced by high-LET radiation. Radiat. Res. 164, 518-521 (2005).
    • (2005) Radiat. Res. , vol.164 , pp. 518-521
    • Desai, N.1    Davis, E.2    O'Neill, P.3    Durante, M.4    Cucinotta, F.A.5    Wu, H.6
  • 36
    • 39749184636 scopus 로고    scopus 로고
    • Biochemical kinetics model of DSB repair and c-H2AX foci by non-homologous end joining
    • F. A. Cucinotta, J. M. Pluth, J. Anderson, J. V. Harper and P. O'Neill, Biochemical kinetics model of DSB repair and c-H2AX foci by non-homologous end joining. Radiat. Res. 169, 214-222 (2008).
    • (2008) Radiat. Res. , vol.169 , pp. 214-222
    • Cucinotta, F.A.1    Pluth, J.M.2    Anderson, J.3    Harper, J.V.4    O'Neill, P.5
  • 37
    • 54749148734 scopus 로고    scopus 로고
    • Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation
    • M. D. Rainey, M. E. Charlton, R. V. Stanton and M. B. Kastan, Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 68, 7466-7474 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 7466-7474
    • Rainey, M.D.1    Charlton, M.E.2    Stanton, R.V.3    Kastan, M.B.4
  • 38
    • 0042242630 scopus 로고    scopus 로고
    • Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays
    • S. H. MacPhail, J. P. Banath, T. Y. Yu, E. H. Chu, H. Lambur and P. L. Olive, Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays. Int. J. Radiat. Biol. 79, 351-358 (2003).
    • (2003) Int. J. Radiat. Biol. , vol.79 , pp. 351-358
    • MacPhail, S.H.1    Banath, J.P.2    Yu, T.Y.3    Chu, E.H.4    Lambur, H.5    Olive, P.L.6
  • 39
    • 0142011461 scopus 로고    scopus 로고
    • The cellular response to DNA double-strand breaks: Defining the sensors and mediators
    • J. H. Petrini and T. H. Stracker, The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol. 13, 458-462 (2003).
    • (2003) Trends Cell Biol. , vol.13 , pp. 458-462
    • Petrini, J.H.1    Stracker, T.H.2
  • 40
    • 0025284768 scopus 로고
    • Radiosensitivity throughout the cell cycle and repair of potentially lethal damage and DNA double-strand breaks in an X-ray-sensitive CHO mutant
    • G. E. Iliakis and R. Okayasu, Radiosensitivity throughout the cell cycle and repair of potentially lethal damage and DNA double-strand breaks in an X-ray-sensitive CHO mutant. Int. J. Radiat. Biol. 57, 1195-1211 (1990).
    • (1990) Int. J. Radiat. Biol. , vol.57 , pp. 1195-1211
    • Iliakis, G.E.1    Okayasu, R.2
  • 41
    • 0026408543 scopus 로고
    • Oxygen enhancement ratio as a function of dose and cell cycle phase for radiation-resistant and sensitive CHO cells
    • J. P. Freyer, K. Jarrett, S. Carpenter and M. R. Raju, Oxygen enhancement ratio as a function of dose and cell cycle phase for radiation-resistant and sensitive CHO cells. Radiat. Res. 127, 297-307 (1991).
    • (1991) Radiat. Res. , vol.127 , pp. 297-307
    • Freyer, J.P.1    Jarrett, K.2    Carpenter, S.3    Raju, M.R.4
  • 43
    • 0026643081 scopus 로고
    • Direct comparison of biological effectiveness of protons and alpha particles of the same LET III. Initial yield of DNA double-strand breaks in V79 cells
    • T. J. Jenner, M. Belli, D. T. Goodhead, F. Ianzini, G. Simone and M. A. Tabocchini, Direct comparison of biological effectiveness of protons and alpha particles of the same LET III. Initial yield of DNA double-strand breaks in V79 cells. Int. J. Radiat. Biol. 61, 631-637 (1992).
    • (1992) Int. J. Radiat. Biol. , vol.61 , pp. 631-637
    • Jenner, T.J.1    Belli, M.2    Goodhead, D.T.3    Ianzini, F.4    Simone, G.5    Tabocchini, M.A.6
  • 44
    • 0028069479 scopus 로고
    • Use of radiation quality as a probe for DNA lesion complexity
    • K. M. Prise, Use of radiation quality as a probe for DNA lesion complexity. Int. J. Radiat. Biol. 65, 43-48 (1994).
    • (1994) Int. J. Radiat. Biol. , vol.65 , pp. 43-48
    • Prise, K.M.1
  • 45
    • 0027930322 scopus 로고
    • DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method
    • DOI 10.2307/3578657
    • B. Rydberg, M. Lobrich and P. K. Cooper, DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method. Radiat. Res. 139, 133-141 (1994). (Pubitemid 24262431)
    • (1994) Radiation Research , vol.139 , Issue.2 , pp. 133-141
    • Rydberg, B.1    Lobrich, M.2    Cooper, P.K.3
  • 47
    • 0034077890 scopus 로고    scopus 로고
    • Radiation-induced heat-labile sites that convert into DNA double-strand breaks
    • B. Rydberg, Radiation-induced heat-labile sites that convert into DNA double-strand breaks. Radiat. Res. 153, 805-812 (2000).
    • (2000) Radiat. Res. , vol.153 , pp. 805-812
    • Rydberg, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.