Niflumic acid and MSI-2216 reduce TNF-α-induced mucin expression in human airway mucosa

Journal of Allergy and Clinical Immunology

Volumn 115, Issue 2, 2005, Pages 266-271

  Hauber, Hans Peter ^a,e   Daigneault, Patrick ^a   Frenkiel, Saul ^b   Lavigne, Francois ^c   Hung, Hsiao Ling ^d   Levitt, Roy C ^d   Hamid, Qutayba ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c NOTRE DAME HOSPITAL   (Canada)

^d Genaera Corporation   (United States)

^e RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Airway; Explant model; hCLCA1; Inhibition; Laser capture microdissection; MSI 2216; MUC5AC; Mucin; Niflumic acid; TNF

Indexed keywords

CHLORIDE CHANNEL BLOCKING AGENT; CYCLOOXYGENASE 2; MESSENGER RNA; MSI 2216; MUCIN 5AC; NIFLUMIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EXPLANT; HUMAN; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; MUCOSA CELL; MUCUS SECRETION; NUCLEOTIDE SEQUENCE; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT MUCOSA; STIMULATION; UPPER RESPIRATORY TRACT;

EID: 13444310932     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.09.039     Document Type: Article

References (22)

1. C.L. Ordonez, R. Khashayar, H.H. Wong, R.E. Ferrando, R. Wu, and D.M. Hyde Mild and moderate asthma is associated with goblet cell hyperplasia and abnormalities in mucin expression Am J Respir Crit Care Med 163 2001 517 523
2. R.M. Senior, and S.D. Shapiro Chronic obstructive pulmonary disease: epidemiology, pathophysiology, and pathogenesis A.P. Fishman Fishman's pulmonary diseases and disorders 1998 McGraw-Hill New York 659 681
3. M.J. Welsh, L.C. Tsui, T.F. Boat, and A.L. Beaudet Cystic fibrosis W.S. Sly D. Valle The metabolic and molecular basis of inherited diseases 1995 McGraw-Hill New York 3799 3876
4. A. Nakanishi, S. Morita, H. Iwashita, Y. Sagiya, Y. Ashida, and H. Shirafuji Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma Proc Natl Acad Sci U S A 98 2001 5175 5180
5. M. Toda, M.K. Tulic, R.C. Levitt, and Q. Hamid A calcium-activated chloride channel (hCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma J Allergy Clin Immunol 109 2002 246 250
6. H.P. Hauber, J.J. Manoukian, L.H. Nguyen, S.E. Sobol, R.C. Levitt, and K.J. Holroyd Increased expression of interleukin-9, interleukin-9 receptor, and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cystic fibrosis Laryngoscope 113 2003 1037 1042
7. Y. Zhou, M. Shapiro, Q. Dong, J. Louahed, C. Weiss, and S. Wan A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction Novartis Fund Symp 248 2002 150 165
8. R.J. Dandurand, C.G. Wang, S. Laberge, J.G. Martin, and D.H. Eidelman In vitro allergic bronchoconstriction in the Brown Norway rat Am J Respir Crit Care Med 149 1994 1499 1505
9. E. Minshall, C.G. Wang, R. Dandurand, and D. Eidelman Heterogeneity of responsiveness of individual airways in cultured lung explants Can J Physiol Pharmacol 75 1997 911 916
10. A. Giaid, R.P. Michel, D.J. Stewart, M. Sheppard, B. Corrin, and Q. Hamid Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis Lancet 341 1993 1550 1554
11. H.W. Hovenberg, J.R. Davies, A. Herrmann, C.J. Linden, and I. Carlstedt MUC5AC, but not MUC2, is a prominent mucin in respiratory secretions Glycoconj J 13 1996 839 847
12. Y.D. Kim, E.J. Kwon, D.W. Park, S.Y. Song, S.K. Yoon, and S.H. Baek Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells Mol Pharmacol 62 2002 1112 1118
13. J.P. Audie, A. Janin, N. Porchet, M.C. Copin, B. Gosselin, and J.P. Aubert Expression of human mucin genes in the respiratory, digestive, and reproductive tracts ascertained by in situ hybridization J Histochem Cytochem 41 1993 1479 1485
14. M.T. Borchers, M.P. Carty, and G.D. Leikauf Regulation of human airway mucins by acrolein and inflammatory mediators Am J Physiol 276 1999 L549 L555
15. S.J. Levine, P. Larivee, C. Logun, C.W. Angus, F.P. Ognibene, and J.H. Shelhamer Tumor necrosis factor-alpha induces mucin hypersecretion and MUC2 gene expression by human airway epithelial cells Am J Respir Cell Mol Biol 12 1995 196 204
16. K.S. Song, W.J. Lee, K.C. Chung, J.S. Koo, E.J. Yang, and J.Y. Choi Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells J Biol Chem 278 2003 24243 24250
17. V. Ackerman, M. Marini, E. Vittori, A. Bellini, G. Vassali, and S. Mattoli Detection of cytokines and their cell sources in bronchial biopsy specimens form asthmatic patients: relationship to atopic status, symptoms, and level of airway hyperresponsiveness Chest 105 1994 687 696
18. V.M. Keatings, P.D. Collins, D.M. Scott, and P.J. Barnes Differences in interleukin-8 and tumor necrosis factor-α in induced sputum in patients with chronic obstructive pulmonary disease or asthma Am J Respir Crit Care Med 153 1996 530 534
19. K.D. Pfeffer, T.P. Hueckstaedt, and J.R. Hoidal Expression and regulation of tumor necrosis factor in macrophages from cystic fibrosis patients Am J Respir Cell Mol Biol 9 1993 511 519
20. J.G. Wagner, J.R. Harkema, R.C. Levitt, and K.J. Holroyd Attenuation of endotoxin-induced mucus hypersecretion and airway inflammation by MSI-2216, a calcium-activated chloride channel inhibitor [abstract] Am J Respir Crit Care Med 167 2003 A466
21. J. Barnett, J. Chow, D. Ives, M. Chiou, R. Mackenzie, and E. Osen Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system Biochim Biophys Acta 324 1994 26 34
22. A.D. Gruber, R.C. Elble, H.-L. Ji, K.D. Schreur, C.M. Fuller, and B.U. Pauli Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel protein Genomics 54 1998 200 214