Loop 2 of ophiophagus hannah toxin b binds with neuronal nicotinic acetylcholine receptors and enhances intracranial drug delivery

Molecular Pharmaceutics

Volumn 7, Issue 6, 2010, Pages 1940-1947

  Zhan, Changyou ^a   Yan, Zhiqiang ^a   Xie, Cao ^a   Lu, Weiyue ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA BUNGAROTOXIN I 125; COUMARIN; FLUORESCENT DYE; MACROGOL; NEUROTOXIN; NICOTINIC RECEPTOR; OPHIOPHAGUS HANNAH TOXIN B; OPHIOPHAGUS HANNAH TOXIN POLYETHYLENE GLYCOL POLYLACTIC ACID PACLITAXEL CONJUGATE; PACLITAXEL; POLYLACTIC ACID; SNAKE VENOM; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RECEPTOR BINDING; ENCAPSULATION; ENDOCYTOSIS; ENDOTHELIUM CELL; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MICELLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RABIES VIRUS; RAT; SURVIVAL TIME;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CENTRAL NERVOUS SYSTEM NEOPLASMS; COBRA VENOMS; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; GLIOBLASTOMA; HELA CELLS; HUMANS; LACTATES; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICELLES; NEURONS; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; TISSUE DISTRIBUTION;

EID: 78649965095     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100238j     Document Type: Article

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