Pharmacokinetics of erythropoietin in genetically anemic mice

Drug Metabolism and Disposition

Volumn 26, Issue 2, 1998, Pages 126-131

  Kato, Motohiro ^b   Miura, Kumi ^b   Kamiyama, Hiroshi ^b   Okazaki, Akira ^b   Kumaki, Kenji ^b   Kato, Yukio ^b   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN RECEPTOR; IODINE 125; RECOMBINANT ERYTHROPOIETIN;

ANEMIA; ANIMAL MODEL; ANIMAL TISSUE; APLASTIC ANEMIA; AREA UNDER THE CURVE; ARTICLE; BONE MARROW; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG CLEARANCE; DRUG DISPOSITION; DRUG UPTAKE; HEMATOCRIT; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SPLEEN;

ANIMALS; BONE MARROW; ERYTHROPOIETIN; GENOTYPE; HEMATOCRIT; IODINE RADIOISOTOPES; KINETICS; MALE; MICE; MICE, INBRED STRAINS; RECOMBINANT PROTEINS; REGRESSION ANALYSIS; SPLEEN;

ANIMALIA; MICA;

EID: 0031915898     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Krantz SB (1991) Erythropoietin. Blood 77:419-43.
2. Miyake T, Kung CK-H, and Goldwasser E (1977) Purification of human erythropoietin. J Biol Chem 252:5558-5564.
3. Jacobs K, Shoemaker C, Rudersdorf R, Neill SD, Kaufman RJ, Mufson A, Seehra J, Jones SS, Hewick R, Fritsch EF, Kawakita M, Shimizu T, and Miyake T (1985) Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature (Lond) 313:806-810.
4. Lin F-K, Suggs S, Lin C-H, Browne JK, Smalling R, Egrie JC, Chen KK, Fox GM, Martin F, Stabinsky Z, Badrawi SM, Lai P-H, and Goldwasser E (1985) Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA 82:7580-7584.
5. Winearls CG, Oliver DO, Pippard MJ, Reid C and Downing MR (1986) Effect of human erythropoietin derived from recombinant DNA on anemic of patients maintained by the chronic haemodialysis. Lancet 11:1175.
6. Eschbach JW, Egrie JC, Downing MR, Browne JK, and Adamson JW (1987) Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. N Engl J Med 316:73.
7. Hirashima K, Bessho M, Nagata A, Hirasawa Y, Suzuki S, Miura K, Suda T, Kawai T, Sotoyama K, Yoshikawa O, Aoki I, Mori M, Yoshida Y, Horiuchi A, Hamazaki H, Hidai H, Oowada S and Maenami T (1990) Clinical evaluation of radioimmunoassay of erythropoietin. J Med Pharmceut Sci 24:703-711.
8. Hirashima K, Bessho M, Jinnai I (1990) Improvement of anemia by recombinant human erythropoietin (rhEPO) in patients with myelodysplastic syndrome (MDS) and aplastic anemia. Contrib Nephrol 88:254-264.
9. Musolino C, Orlando A, Alonci A, Santoro MC, Bellomo G, Quartarone M and Squadrito G (1994) Effective therapy of aplastic anaemia post-hepatitis with recombinant human erythropoietin. Am J Hematol 46:59-60.
10. Urabe A, Mizoguchi H, Takaku F, Miyazaki T, Yachi A, Niitsu Y, Miura Y, Mutoh Y, Fujioka S and Nomura T (1993) Effects of rHuEPO on aplastic anemia: results of a Phase II Clinical Study. Rinsyo-ketueki 34:1002-1010.
11. v marrow. Blood 30:601-616.
12. Bernstein SE (1970) Tissue transplantation as an analytic and therapeutic tool in hereditary anemias. Am J Surg 119:448-451.
13. 41 and W. EMBO J 9:1805-1813.
14. Cynshi O, Satoh K, Higuchi M, Imai N, Kawaguchi T and Hirashima K (1990) Effects of recombinant human erythropoietin on anaemic W/Wv and Sl/Sld mice. Br J Haematol 75:319-324.
15. Kato M, Kamiyama H, Okazaki A, Kumaki K, Kato Y and Sugiyama Y (1997). Mechanism for the Nonlinear Pharmacokinetics of Erythropoietin in Rats. J Pharm Exp Ther, 283:520-527.
16. Kinoshita H, Ohishi N, and Okazaki A (1991) Preparation of iodine labeled recombinant human erythropoietin. Arzneim-Forsch/Drug Res 41:568-570.
17. Yamaoka K, Tanigawara Y, Nakagawa T and Uno T (1981) A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharm Dyn 4:879-885.
18. Loeffler M and Wichmann HE 1985 Mathematical Modeling of Cell Proliferation: Stem Cell Regulation in Hemopoiesis, Vol. II, pp. 163, CRC Press, Boca Raton, Fla,
19. Flaharty KK, Caro J, Erslev A, Whalen JJ, Morris EM, Bjornsson TD and Vlasses PH (1990) Pharmacokinetics and erythropoietic response to human recombinant erythropoietin in healthy men. Clin Pharmacol Ther 47:557-564.
20. Browen D, Ehmer B, Neubert P, Lewis T, and Jacobs A (1991) The clearance of a single iv bolus recombinant human erythropoietin from the serum of patients with myelodyplastic syndrome and its effects on erythropoiesis. Exp Hematol 19:613-616.
21. Kabaya K, Akiyama H, Nishi N, Misaizu T, Okada Y, Kawagishi M, Amano K, Kusaka M, Seki M and Uzumaki H (1995) Improvement of anemia in W/Wv mice by recombinant human erythropoietin (rHuEPO) mediated through EPO receptors with lowered affinity. Life Sci 57:1067-1076.
22. Kubo T and Nakahata T (1993) Different responses of human marrow and circulating erythroid progenitors to stem cell factor, interleukin-3 and granulocyte/macrophage colony-stimulating factor. Int J Hematol 58:153-162.
23. Wu H, Klingmuller U, Besmer P, and Lodish HF (1995) Interaction of the erythropoietin and stem-cell-factor receptors. Nature (Lond) 377:242-246.
24. Nijhof W, Goris H, Dontje B, Dresz J, and Loeffler M (1993) Optimal erythroid cell production during erythropoietin treatment of mice occurs by exploiting the splenic microenvironment. Exp Hematol 21:496-501.
25. d Mutant. Cell 64:1025-1035.
26. Kodama H, Nose M, Niida S, Nishikawa S, and Nishikawa S (1994) Involvement of the c-kit receptor in the adhesion of hematopoietic stem cell to stromal cells. Exp Hematol 22:979-984.
27. Dastych J and Metcalf DD (1994) Stem Cell Factor Induces Mast Cell Adhesion to Fibronectin. J Immunol 152:213-219.
28. Kinashi T and Springer TA (1994) Steel Factor and c-kit Regulate Cell-Matrix Adhesion. Blood 83:1033-1038.