Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Herzberg Schäfer, Silke A ^a   Staiger, Harald ^a   Heni, Martin ^a   Ketterer, Caroline ^a   Guthoff, Martina ^a   Kantartzis, Konstantinos ^a   Machicao, Fausto ^a   Stefan, Norbert ^a   Häring, Hans Ulrich ^a   Fritsche, Andreas ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CYCLIN DEPENDENT KINASE; GENE PRODUCT; GLUCOSE; HOMEODOMAIN PROTEIN; INCRETIN; INSULIN; MELATONIN 1 RECEPTOR; POTASSIUM CHANNEL KCNQ1; PROTEIN CDKAL1; PROTEIN HHEX; PROTEIN MTNR1B; PROTEIN WFS1; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CAUCASIAN; CLINICAL EVALUATION; CONTROLLED STUDY; EUROPE; EXPERIMENTAL MODEL; FEMALE; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC RISK; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; MOLECULAR DYNAMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; POSTPRANDIAL STATE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; COHORT ANALYSIS; DIET RESTRICTION; GLUCOSE TOLERANCE TEST; METABOLISM; REGRESSION ANALYSIS; RISK;

ADULT; AREA UNDER CURVE; BLOOD GLUCOSE; C-PEPTIDE; COHORT STUDIES; FASTING; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REGRESSION ANALYSIS; RISK;

EID: 78649922167     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014194     Document Type: Article

References (23)

1. McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, et al. (2008) Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 9: 356-369.
2. Staiger H, Machicao F, Fritsche A, Haring HU (2009) Pathomechanisms of type 2 diabetes genes. Endocr Rev 30: 557-585.
3. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, et al. (2009) Finding the missing heritability of complex diseases. Nature 461: 747-753.
4. Sluiter WJ, Erkelens DW, Reitsma WD, Doorenbos H (1976) Glucose tolerance and insulin release, a mathematical approach I. Assay of the beta-cell response after oral glucose loading. Diabetes 25: 241-244.
5. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
6. Wareham NJ, Phillips DI, Byrne CD, Hales CN (1995) The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion. Diabet Med 12: 931.
7. Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Jarvinen H, et al. (2000) Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23: 295-301.
8. Utzschneider KM, Prigeon RL, Faulenbach MV, Tong J, Carr DB, et al. (2009) Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care 32: 335-341.
9. Stancakova A, Javorsky M, Kuulasmaa T, Haffner SM, Kuusisto J, et al. (2009) Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes 58: 1212-1221.
10. Kadowaki T, Miyake Y, Hagura R, Akanuma Y, Kajinuma H, et al. (1984) Risk factors for worsening to diabetes in subjects with impaired glucose tolerance. Diabetologia 26: 44-49.
11. Stefan N, Machicao F, Staiger H, Machann J, Schick F, et al. (2005) Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia 48: 2282-2291.
12. Staiger H, Machicao F, Schafer SA, Kirchhoff K, Kantartzis K, et al. (2008) Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS ONE 3: e3962.
13. Sparso T, Bonnefond A, Andersson E, Bouatia-Naji N, Holmkvist J, et al. (2009) G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes 58: 1450-1456.
14. Grarup N, Rose CS, Andersson EA, Andersen G, Nielsen AL, et al. (2007) Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes 56: 3105-3111.
15. Staiger H, Machicao F, Stefan N, Tschritter O, Thamer C, et al. (2007) Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS ONE 2: e832.
16. Stancakova A, Pihlajamaki J, Kuusisto J, Stefan N, Fritsche A, et al. (2008) Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab 93: 1924-1930.
17. Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, et al. (2008) Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia 51: 1659-1663.
18. Schafer SA, Tschritter O, Machicao F, Thamer C, Stefan N, et al. (2007) Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 50: 2443-2450.
19. Lyssenko V, Lupi R, Marchetti P, del Guerra S, Orho-Melander M, et al. (2007) Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117: 2155-2163.
20. Schafer SA, Mussig K, Staiger H, Machicao F, Stefan N, et al. (2009) A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion. Diabetologia 52: 1075-1082.
21. Mussig K, Staiger H, Machicao F, Kirchhoff K, Guthoff M, et al. (2009) Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. Diabetes 58: 1715-1720.
22. Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-1470.
23. Polonsky KS, Rubenstein AH (1984) C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations. Diabetes 33: 486-494.