Specificity of a prodrug-activating enzyme hVACVase: The leaving group effect

Molecular Pharmaceutics

Volumn 7, Issue 6, 2010, Pages 2362-2368

  Sun, Jing ^a   Dahan, Arik ^b   Walls, Zachary F ^a   Lai, Longsheng ^c   Lee, Kyung Dall ^a   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMINO ACID; ESTER DERIVATIVE; HUMAN VALACYCLOVIRASE; HYDROLASE; PHENYLALANINE; PRODRUG; UNCLASSIFIED DRUG; VALACICLOVIR; VALGANCICLOVIR; VALINE;

ANIMAL CELL; ARTICLE; CHEMICAL REACTION; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL;

AMIDES; BIOCATALYSIS; CARBOXYLIC ESTER HYDROLASES; HUMANS; PRODRUGS; SUBSTRATE SPECIFICITY;

EID: 78649913370     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100300k     Document Type: Article

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