Antiepileptic action of exogenous dehydroepiandrosterone in iron-induced epilepsy in rat brain

Epilepsy and Behavior

Volumn 19, Issue 3, 2010, Pages 264-271

  Mishra, Monika ^a   Singh, Rameshwar ^a   Sharma, Deepak ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Dehydroepiandrosterone; Electrical seizures; Iron induced epilepsy; Lipid peroxidation; Morris water maze test; Na+, K+ ATPase activity; Open field test; Protein oxidation; Seizure

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM); ANTICONVULSIVE AGENT; IRON; PRASTERONE;

ADRENAL CORTEX; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIEPILEPTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ELECTROPHYSIOLOGY; EPILEPTOGENESIS; FOCAL EPILEPSY; HORMONE SYNTHESIS; LIPID PEROXIDATION; MALE; MAZE TEST; NONHUMAN; OPEN FIELD TEST; OXIDATIVE STRESS; RAT; TRAUMATIC EPILEPSY; TREATMENT DURATION;

ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; BRAIN; DEHYDROEPIANDROSTERONE; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; EPILEPSY; EXPLORATORY BEHAVIOR; IRON; LIPID PEROXIDATION; MALE; MAZE LEARNING; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; REGRESSION ANALYSIS; SODIUM-POTASSIUM-EXCHANGING ATPASE; TIME FACTORS;

EID: 78649904631     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2010.06.048     Document Type: Article

References (68)

1. Willmore L.J., Sypert G.W., Munson J.B. Recurrent seizures induced by cortical iron injection: a model of posttraumatic epilepsy. Ann Neurol 1978, 4:329-336.
2. Sharma V., Prakash-Babu P., Singh A., Singh S., Singh R. Iron-induced experimental cortical seizures: electroencephalographic mapping of seizure spread in the subcortical brain areas. Seizure 2007, 16:680-690.
3. Willmore L.J., Rubin J.J. Antiperoxidant pretreatment and iron-induced epileptiform discharges in the rat: EEG and histopathologic studies. Neurology 1981, 31:61-69.
4. 3-induced epileptogenic foci in the rat brain. Epilepsia 1990, 31:15-26.
5. Moriwaki A., Hattori Y., Hayashi Y., Hori Y. Development of epileptic activity induced by iron injection into rat cerebral cortex: electrographic and behavioral characteristics. Electroencephalogr Clin Neurophysiol 1992, 83:281-288.
6. Jyoti A., Sethi P., Sharma D. Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis. Epilepsy Behav 2009, 14:300-308.
7. Baulieu E.E., Robel P., Schumacher M. Neurosteroids: beginning of the story. Int Rev Neurobiol 2001, 46:1-32.
8. Kimoto T., Tsurugizawa T., Ohta Y., et al. Neurosteroid synthesis by cytochrome P450-containing systems localized in the rat brain hippocampal neurons: N-methyl-D-aspartate and calcium-dependent synthesis. Endocrinology 2001, 142:3578-3589.
9. Rupprecht R., Holsboer F. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 1999, 22:410-416.
10. Beyenburg S., Stoffel-Wagner B., Bauer J., et al. Neuroactive steroids and seizure susceptibility. Epilepsy Res 2001, 44:141-153.
11. Boccuzzi G., Aragno M., Seccia M., et al. Protective effect of dehydroepiandrosterone against copper-induced lipid peroxidation in the rat. Free Radic Biol Med 1997, 22:1289-1294.
12. Aragno M., Tamagno E., Gatto V., et al. Dehydroepiandrosterone protects tissues of streptozotocin-treated rats against oxidative stress. Free Radic Biol Med 1999, 26:1467-1474.
13. Bastianetto S., Ramassamy C., Poirier J., Quirion R. Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Mol Brain Res 1999, 66:35-41.
14. Kimonides V.G., Khatibi N.H., Svendsen C.N., Sofroniew M.V., Herbert J. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc Natl Acad Sci USA 1998, 95:1852-1857.
15. Galimberti C.A., Magri F., Copello F., et al. Seizure frequency and cortisol and dehydroepiandrosterone sulphate (DHEAS) levels in women with epilepsy receiving antiepileptic drug treatment. Epilepsia 2005, 46:517-523.
16. Frye C.A. Neurosteroid effects and mechanism for social, cognitive, emotional and physical functions. Psychoneuroendocrinology 2009, 345:143-161.
17. Baulieu E.E., Robel P. Dehydroepiandrosterone and dehydroepiandrosterone sulphate as neuroactive neurosteroids. J Endocrinol 1996, 150:221-239.
18. Bergeron R., Montigny C., Debonnel G. Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors. J Neurosci 1996, 16:1193-1202.
19. Celec P., Starka L. Dehydroepiandrosterone: is the fountain of youth drying out?. Physiol Res 2003, 52:397-407.
20. Roshan S., Nader S., Orlande P. Ageing and hormones. Eur J Clin Invest 1999, 29:210-213.
21. Persad V., Guin Ting Wong C., Cortez M.A., Wang Y.T., Snead O. Hormonal regulation of atypical absence seizures. Ann Neurol 2004, 55:353-361.
22. Scharfman H.E., MacLusky N.J. The influence of gonadal hormones on neuronal excitability, seizures and epilepsy in the female. Epilepsia 2006, 47:1423-1440.
23. Leppik I.E. Epilepsy in the elderly: scope of the life problem. Int Rev Neurobiol 2007, 81:1-14.
24. Frye C.A., Reed T.A.W. Androgenic neurosteroids: anti-seizure effects in animal model of epilepsy. Psychoneuroendocrinology 1998, 23:385-399.
25. Wen S., Dong K., Onolfo J.P., Vincens M. Treatment with dehydroepiandrosterone sulfate increases NMDA receptors in hippocampus and cortex. Eur J Pharmacol 2001, 430:373-374.
26. Marx E.C., Jarskog L.F., Lauder J.M., Gilmore J.H., Lieberman J.A., Morrow A.L. Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia. Brain Res 2000, 871:104-112.
27. Chen J., Li H.L., Luo C., Li Z., Zieng J.H. Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in cat. Brain Res 1999, 844:98-105.
28. Van Goor F., Krsmanovic L.Z., Catt K.J., Stojilkovic S.S. Coordinate regulation of gonadotropin releasing hormone neuronal firing patterns by cytosolic calcium and store depletion. Proc Natl Acad Sci U S A 1999, 96:4101-4106.
29. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1982, Academic Press, New York.
30. Sharma D., Maurya A.K., Singh R. Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine. Neurobiol Aging 1993, 14:319-330.
31. Kaur J., Singh S., Sharma D., Singh R. Aluminium-induced enhancement of ageing-related biochemical and electrophysiological parameters in rat brain regions. Indian J Biochem Biophys 2003, 40:330-339.
32. Mayanil C.S., Kazmi S.M., Baquer N.Z. Changes in monoamine oxidase activity in rat brain during alloxan diabetes. J Neurochem 1982, 38:179-183.
33. Liu R., Liu I.Y., Thompson R.F., Doctrow S.R., Malfroy B., Baudry M. Reversal of age related learning and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc Natl Acad Sci U S A 2003, 100:8526-8531.
34. +-ATPase in rat striatum. J Neurochem 1979, 32:269-271.
35. Fiske C.H., Subbarow J. The colorimetric determination of phosphorus. J Biol Chem 1925, 66:375-400.
36. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-355.
37. Li Y., Qin H., Chen Q.S., Wang J.J. Neurochemical and behavioral effects of the intrahippocampal co-injection of h-amyloid protein 1-40 and ibotenic acid in rats. Life Sci 2005, 76:1189-1197.
38. Suarez-Fernandez M.B., Soldado A.B., Sanz-Mendel A., Vega J.A., Novelli A., Fernandez-Sanchez M.T. Aluminum-induced degeneration of astrocytes occurs via apoptosis and results in neuronal death. Brain Res 1999, 835:125-136.
39. Colomina M.T., Sanchez D.J., Sanchez-Turet M., Domingo J.L. Behavioral effects of aluminum in mice: influence of restraint stress. Neuropsychobiology 1999, 40:142-149.
40. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984, 11:47-60.
41. Sethi P., Jyoti A., Hussain E., Sharma D. Curcumin attenuates aluminum-induced functional neurotoxicity in rats. Pharmacol Biochem Behav 2009, 93:31-39.
42. Ozdemir D., Tugyan K., Uysal N., Sonmezb U., Sonmezc A., Acikgoz O. Protective effect of melatonin against head trauma-induced hippocampal damage and spatial memory deficits in immature rats. Neurosci Lett 2005, 385:234-239.
43. Walf A.A., Rhodes M.E., Frye C.A. Ovarian steroids enhance object recognition in natural cycling and ovariectomized, hormone-primed rats. Neurobiol Learn Memory 2006, 86:35-46.
44. Frye C.A., Lacey E.H. The neurosteroid DHEA and DHEAS may influence cognitive performance by altering affective state. Physiol Behav 1999, 66:85-92.
45. Willmore L.J., Triggs W.J. Effect of phenytoin and corticosteroids on seizures and lipid peroxidation in experimental posttraumatic epilepsy. J Neurosurg 1984, 60:467-472.
46. +-ATPase in the brain. Epilepsia 1992, 33:58-64.
47. Lees G.J. Inhibition of sodium-potassium-ATPase: a potentially ubiquitous mechanism contributing to central nervous system neuropathology [review]. Brain Res Brain Res Rev 1991, 16:283-300.
48. Goddard G.A., Robinson J.D. Uptake and release of calcium by rat brain synaptosomes. Brain Res 1976, 110:331-350.
49. Sinha N., Taha A., Baquer N.Z., Sharma D. Exogenous adminstration of dehydroepiandrosterone attenuates loss of superoxide dismutase activity in the brain of old rats. Indian J Biochem Biophys 2008, 45:57-60.
50. Sinha N., Baquer N.Z., Sharma D. Anti-lipid peroxidative role of exogenous dehydroepiandrosterone (DHEA) administration in normal ageing rat brain. Indian J Exp Biol 2005, 43:420-424.
51. Mattson M.P. Modification of ion homeostasis by lipid peroxidation: role in neuronal degeneration and adaptive plasticity. Trends Neurosci 1998, 21:53-57.
52. +-ATPase activity in response to exogenous dehydroepiandrosterone administration in ageing rat brain. Indian J Exp Biol 2008, 46:852-854.
53. Flood J.F., Morley J.E., Roberts E. Memory enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci U S A 1992, 89:1567-1571.
54. Melchior C.L., Ritzman R.F. Neurosteroids block the memory-impairing effects of ethanol in mice. Pharmacol Biochem Behav 1996, 53:51-56.
55. Backstrom T., Landgren A., Zetterlund, et al. Effects of ovarian steroid hormones on brain excitability and their relation to epilepsy seizure variation during the menstrual cycle. Adv Epileptol 1984, 15:269-277.
56. Logothetis J., Harner R., Morrell F., Torres F. The role of estrogens in catamenial exacerbation of epilepsy. Neurology 1959, 9:352-360.
57. Herzog A.G., Klein P., Jacobs A.R. Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism. Neurology 1998, 50:782-784.
58. Ruusa J., Bergman B. Sex hormone and alcohol withdrawal: does a good supply of testosterone prevent serious symptoms during detoxification?. Alcohol 1996, 13:139-145.
59. Tan M., Tan U. Effect of testosterone and clomiphene on spectral EEG and visual evoked response in a young man with posttraumatic epilepsy. Int J Neurosci 2001, 106:87-94.
60. Frye C.A. Hormonal influence on seizures: basic neurobiology. Int Rev Neurobiol 2008, 83:27-77.
61. Frye C.A., Rhodes M.E. Male sex steroids and neuronal excitability. Encyclopedia of basic epilepsy research 2009, 507-513. Academic Press, Oxford. P. Schwartzkroin (Ed.).
62. Frye C.A., Rhodes M.E. Female sex steroids and neuronal excitability. Encyclopedia of basic epilepsy research 2009, 477-484. Academic Press, Oxford. P. Schwartzkroin (Ed.).
63. Majewska M.D. Neurosteroids: endrogenous bimodal modulators of the GABA-A receptor: mechanism of action and physiological significance. Prog Neurobiol 1992, 38:379-395.
64. Bowlby M.R. Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons. Mol Pharmacol 1993, 43:813-819.
65. 2+ responses: structure-activity studies. J Pharmacol Exp Ther 1994, 271:677-682.
66. Maurice T., Lockhart B.P. Neuroprotective and anti-amnesic potentials of sigma receptor ligands. Prog Neuro-psychopharmacol Biol Psychiatry 1997, 21:69-102.
67. 2+ channel current in freshly isolated hippocampal CA1 neurons. Eur J Pharmacol 1991, 202:269-272.
68. Mao X., Barger S.W. Neuroprotection by dehydroepiandrosterone-sulfate: role of an NFkB-like factor. NeuroReport 1998, 9:759-763.