In vivo canine model comparison of cardiovascular effects of antidepressants milnacipran and imipramine

Cardiovascular Toxicology

Volumn 10, Issue 4, 2010, Pages 275-282

  Mitsumori, Yoshitaka ^a   Nakamura, Yuji ^a   Hoshiai, Kiyotaka ^a,b,c   Nagayama, Yukitoshi ^a,b,c   Adachi Akahane, Satomi ^d   Koizumi, Schuichi ^a   Matsumoto, Masahiko ^a   Sugiyama, Atsushi ^a,b,d  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b Yamanashi Research Center of Clinical Pharmacology   (Japan)

^c Sugi Institute of Biological Science   (Japan)

^d TOHO UNIVERSITY   (Japan)

Author keywords

Effective refractory period; Imipramine; Milnacipran; Monophasic action potential; QT; Torsades de pointes

Indexed keywords

IMIPRAMINE; MILNACIPRAN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL TONE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG MEGADOSE; FEMALE; HEART ELECTROPHYSIOLOGY; HEART HEMODYNAMICS; HEART LEFT VENTRICLE DP-DT; HEART MUSCLE POTENTIAL; HEART OUTPUT; HEART RATE; HEART REPOLARIZATION; HEART VENTRICLE CONTRACTION; IN VIVO STUDY; LONG QT SYNDROME; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; VASCULAR RESISTANCE; VASOCONSTRICTION;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CYCLOPROPANES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; HEART CONDUCTION SYSTEM; HEMODYNAMICS; IMIPRAMINE; INFUSIONS, INTRAVENOUS; LONG QT SYNDROME; MALE; RISK ASSESSMENT; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS; VENTRICULAR FUNCTION;

CANIS FAMILIARIS;

EID: 78649904457     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12012-010-9084-9     Document Type: Article

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