Effects of a typical IKr channel blocker sematilide on the relationship between ventricular repolarization, refractoriness and onset of torsades de pointes

Japanese Journal of Pharmacology

Volumn 88, Issue 4, 2002, Pages 414-421

  Sugiyama, Atsushi ^a   Hashimoto, Keitaro ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

IKr channel; Monophasic action potential; Repolarization; Sematilide; Torsades de pointes

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SEMATILIDE; ANTIARRHYTHMIC AGENT; CATION TRANSPORT PROTEIN; DRUG DERIVATIVE; KCNH6 PROTEIN, HUMAN; POTASSIUM CHANNEL HERG; PROCAINAMIDE; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOG; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; FEMALE; HEART CYCLE; HEART MUSCLE REFRACTORY PERIOD; HEART RATE; HEART REPOLARIZATION; HEART VENTRICLE CONDUCTION; HEART VENTRICLE PACING; HEART VENTRICLE SEPTUM; HEART VENTRICLE TACHYCARDIA; HEMOPERFUSION; INCIDENCE; INTRACORONARY INFUSION; LONG QT SYNDROME; MALE; NONHUMAN; POTASSIUM CURRENT; STIMULUS RESPONSE; TORSADE DES POINTES; ANIMAL; CHEMICALLY INDUCED DISORDER; HEART VENTRICLE; IN VITRO STUDY; PATHOPHYSIOLOGY;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CATION TRANSPORT PROTEINS; DOGS; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; HEART VENTRICLES; MALE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROCAINAMIDE; TORSADES DE POINTES;

EID: 0035985274     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.88.414     Document Type: Article

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