Intracellular acetyl unit transport in fungal carbon metabolism

Eukaryotic Cell

Volumn 9, Issue 12, 2010, Pages 1809-1815

  Strijbis, Karin ^a,b   Distel, Ben ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ACYLTRANSFERASE; CARBON; FUNGAL PROTEIN;

CANDIDA ALBICANS; ENZYMOLOGY; GENETICS; METABOLISM; REVIEW; SACCHAROMYCES CEREVISIAE;

ACETYL COENZYME A; ACETYLTRANSFERASES; CANDIDA ALBICANS; CARBON; FUNGAL PROTEINS; SACCHAROMYCES CEREVISIAE;

CANDIDA ALBICANS; FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 78649892486     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00172-10     Document Type: Review

References (54)

1. Antonenkov, V. D., R. T. Sormunen, and J. K. Hiltunen. 2004. The rat liver peroxisomal membrane forms a permeability barrier for cofactors but not for small metabolites in vitro. J. Cell Sci. 117:5633-5642.
2. Askew, C., A. Sellam, E. Epp, H. Hogues, A. Mullick, A. Nantel, and M. Whiteway. 2009. Transcriptional regulation of carbohydrate metabolism in the human pathogen Candida albicans. PLoS Pathog. 5:e1000612.
3. Brown, A. J., F. C. Odds, and N. A. Gow. 2007. Infection-related gene expression in Candida albicans. Curr. Opin. Microbiol. 10:307-313.
4. Carman, A. J., S. Vylkova, and M. C. Lorenz. 2008. Role of acetyl coenzyme A synthesis and breakdown in alternative carbon source utilization in Candida albicans. Eukaryot. Cell 7:1733-1741.
5. Courtois-Verniquet, F., and R. Douce. 1993. Lack of aconitase in glyoxysomes and peroxisomes. Biochem. J. 294:103-107.
6. Elgersma, Y., C. W. van Roermund, R. J. Wanders, and H. F. Tabak. 1995. Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene. EMBO J. 14:3472-3479.
7. Fernandez, E., F. Moreno, and R. Rodicio. 1992. The ICL1 gene from Saccharomyces cerevisiae. Eur. J. Biochem. 204:983-990.
8. Fleck, C. B., and M. Brock. 2009. Re-characterisation of Saccharomyces cerevisiae Ach1p: fungal CoA-transferases are involved in acetic acid detoxification. Fungal Genet. Biol. 46:473-485.
9. Fradin, C., P. De Groot, D. MacCallum, M. Schaller, F. Klis, F. C. Odds, and B. Hube. 2005. Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol. Microbiol. 56:397-415.
10. Fradin, C., M. Kretschmar, T. Nichterlein, C. Gaillardin, C. d'Enfert, and B. Hube. 2003. Stage-specific gene expression of Candida albicans in human blood. Mol. Microbiol. 47:1523-1543.
11. Franken, J., S. Kroppenstedt, J. H. Swiegers, and F. F. Bauer. 2008. Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection. Curr. Genet. 53:347-360.
12. Gabaldon, T., B. Snel, F. van Zimmeren, W. Hemrika, H. Tabak, and M. A. Huynen. 2006. Origin and evolution of the peroxisomal proteome. Biol. Direct. 1:8.
13. Grunau, S., S. Mindthoff, H. Rottensteiner, R. T. Sormunen, J. K. Hiltunen, R. Erdmann, and V. D. Antonenkov. 2009. Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae. FEBS J. 276:1698-1708.
14. Hartig, A., M. M. Simon, T. Schuster, J. R. Daugherty, H. S. Yoo, and T. G. Cooper. 1992. Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae. Nucleic Acids Res. 20: 5677-5686.
15. Hedges, D., M. Proft, and K. D. Entian. 1995. CAT8, a new zinc clusterencoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 15:1915-1922.
16. Hynes, M. J., S. L. Murray, A. Duncan, G. S. Khew, and M. A. Davis. 2006. Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus Aspergillus nidulans. Eukaryot. Cell 5:794-805.
17. IJlst, L., C. W. van Roermund, V. Iacobazzi, W. Oostheim, J. P. Ruiter, J. C. Williams, F. Palmieri, and R. J. Wanders. 2001. Functional analysis of mutant human carnitine acylcarnitine translocases in yeast. Biochem. Biophys. Res. Commun. 280:700-706.
18. Johnston, M. 1999. Feasting, fasting and fermenting. Glucose sensing in yeast and other cells. Trends Genet. 15:29-33.
19. Kawachi, H., H. Atomi, M. Ueda, N. Hashimoto, K. Kobayashi, T. Yoshida, N. Kamasawa, M. Osumi, and A. Tanaka. 1996. Individual expression of Candida tropicalis peroxisomal and mitochondrial carnitine acetyltransferase- encoding genes and subcellular localization of the products in Saccharomyces cerevisiae. J. Biochem. 120:731-735.
20. Kunau, W. H., V. Dommes, and H. Schulz. 1995. Beta-oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: a century of continued progress. Prog. Lipid Res. 34:267-342.
21. Kunze, M., F. Kragler, M. Binder, A. Hartig, and A. Gurvitz. 2002. Targeting of malate synthase 1 to the peroxisomes of Saccharomyces cerevisiae cells depends on growth on oleic acid medium. Eur. J. Biochem. 269:915-922.
22. Kunze, M., I. Pracharoenwattana, S. M. Smith, and A. Hartig. 2006. A central role for the peroxisomal membrane in glyoxylate cycle function. Biochim. Biophys. Acta 1763:1441-1452.
23. Leighton, F., S. Bergseth, T. Rortveit, E. N. Christiansen, and J. Bremer. 1989. Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation. J. Biol. Chem. 264:10347-10350.
24. Lorenz, M. C., J. A. Bender, and G. R. Fink. 2004. Transcriptional response of Candida albicans upon internalization by macrophages. Eukaryot. Cell 3:1076-1087.
25. Lorenz, M. C., and G. R. Fink. 2001. The glyoxylate cycle is required for fungal virulence. Nature 412:83-86.
26. McCammon, M. T. 1996. Mutants of Saccharomyces cerevisiae with defects in acetate metabolism: isolation and characterization of Acn_ mutants. Genetics 144:57-69.
27. McCammon, M. T., M. Veenhuis, S. B. Trapp, and J. M. Goodman. 1990. Association of glyoxylate and beta-oxidation enzymes with peroxisomes of Saccharomyces cerevisiae. J. Bacteriol. 172:5816-5827.
28. McKinney, J. D., K. Honer zu Bentrup, E. J. Munoz-Elias, A. Miczak, B. Chen, W. T. Chan, D. Swenson, J. C. Sacchettini, W. R. Jacobs, Jr., and D. G. Russell. 2000. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature 406: 735-738.
29. Odds, F. C. 1987. Candida infections: an overview. Crit. Rev. Microbiol. 15:1-5.
30. Palmieri, L., F. M. Lasorsa, V. Iacobazzi, M. J. Runswick, F. Palmieri, and J. E. Walker. 1999. Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. FEBS Lett. 462:472-476.
31. Piekarska, K., G. Hardy, E. Mol, J. van den Burg, K. Strijbis, C. van Roermund, M. van den Berg, and B. Distel. 2008. The activity of the glyoxylate cycle in peroxisomes of Candida albicans depends on a functional betaoxidation pathway: evidence for reduced metabolite transport across the peroxisomal membrane. Microbiology 154:3061-3072.
32. Piekarska, K., E. Mol, M. van den Berg, G. Hardy, J. van den Burg, C. van Roermund, D. MacCallum, F. Odds, and B. Distel. 2006. Peroxisomal fatty acid beta-oxidation is not essential for virulence of Candida albicans. Eukaryot. Cell 5:1847-1856.
33. Pracharoenwattana, I., J. E. Cornah, and S. M. Smith. 2005. Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination. Plant Cell 17:2037-2048.
34. Prigneau, O., A. Porta, and B. Maresca. 2004. Candida albicans CTN gene family is induced during macrophage infection: homology, disruption and phenotypic analysis of CTN3 gene. Fungal Genet. Biol. 41:783-793.
35. Ramirez, M. A., and M. C. Lorenz. 2007. Mutations in alternative carbon utilization pathways in Candida albicans attenuate virulence and confer pleiotropic phenotypes. Eukaryot. Cell 6:280-290.
36. Ramirez, M. A., and M. C. Lorenz. 2009. The transcription factor homolog CTF1 regulates β-oxidation in Candida albicans. Eukaryot. Cell 8:1604- 1614.
37. Regev-Rudzki, N., S. Karniely, N. N. Ben-Haim, and O. Pines. 2005. Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing. Mol. Biol. Cell 16:4163-4171.
38. Rokka, A., V. D. Antonenkov, R. Soininen, H. L. Immonen, P. L. Pirila, U. Bergmann, R. T. Sormunen, M. Weckstrom, R. Benz, and J. K. Hiltunen. 2009. Pxmp2 is a channel-forming protein in mammalian peroxisomal membrane. PLoS One 4:e5090.
39. Rottensteiner, H., A. J. Kal, B. Hamilton, H. Ruis, and H. F. Tabak. 1997. A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Eur. J. Biochem. 247:776-783.
40. Rottensteiner, H., and F. L. Theodoulou. 2006. The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism. Biochim. Biophys. Acta 1763:1527-1540.
41. Rubio-Gozalbo, M. E., J. A. Bakker, H. R. Waterham, and R. J. Wanders. 2004. Carnitine-acylcarnitine translocase deficiency, clinical, biochemical and genetic aspects. Mol. Aspects Med. 25:521-532.
42. Russell, C., and K. M. Lay. 1973. Natural history of Candida species and yeasts in the oral cavities of infants. Arch. Oral Biol. 18:957-962.
43. Schmalix, W., and W. Bandlow. 1993. The ethanol-inducible YAT1 gene from yeast encodes a presumptive mitochondrial outer carnitine acetyltransferase. J. Biol. Chem. 268:27428-27439.
44. Simon, M., G. Adam, W. Rapatz, W. Spevak, and H. Ruis. 1991. The Saccharomyces cerevisiae ADR1 gene is a positive regulator of transcription of genes encoding peroxisomal proteins. Mol. Cell. Biol. 11:699-704.
45. Strijbis, K., C. W. van Roermund, G. P. Hardy, J. van den Burg, K. Bloem, J. de Haan, N. van Vlies, R. J. Wanders, F. M. Vaz, and B. Distel. 2009. Identification and characterization of a complete carnitine biosynthesis pathway in Candida albicans. FASEB J. 23:2349-2359.
46. Strijbis, K., C. W. van Roermund, J. van den Burg, M. van den Berg, G. P. Hardy, R. J. Wanders, and B. Distel. 2010. Contributions of carnitine acetyltransferases to intracellular acetyl unit transport in Candida albicans. J. Biol. Chem. 285:24335-24346.
47. Strijbis, K., C. W. van Roermund, W. F. Visser, E. C. Mol, J. van den Burg, D. M. MacCallum, F. C. Odds, E. Paramonova, B. P. Krom, and B. Distel. 2008. Carnitine-dependent transport of acetyl coenzyme A in Candida albicans is essential for growth on nonfermentable carbon sources and contributes to biofilm formation. Eukaryot. Cell 7:610-618.
48. Swiegers, J. H., N. Dippenaar, I. S. Pretorius, and F. F. Bauer. 2001. Carnitine- dependent metabolic activities in Saccharomyces cerevisiae: three carnitine acetyltransferases are essential in a carnitine-dependent strain. Yeast 18:585-595.
49. Thewes, S., M. Kretschmar, H. Park, M. Schaller, S. G. Filler, and B. Hube. 2007. In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion. Mol. Microbiol. 63:1606-1628.
50. Van den Berg, M. A., and H. Y. Steensma. 1995. ACS2, a Saccharomyces cerevisiae gene encoding acetyl-coenzyme A synthetase, essential for growth on glucose. Eur. J. Biochem. 231:704-713.
51. van Roermund, C. W., Y. Elgersma, N. Singh, R. J. Wanders, and H. F. Tabak. 1995. The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions. EMBO J. 14:3480-3486.
52. van Roermund, C. W., E. H. Hettema, M. van den Berg, H. F. Tabak, and R. J. Wanders. 1999. Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p. EMBO J. 18:5843-5852.
53. White, S. J., A. Rosenbach, P. Lephart, D. Nguyen, A. Benjamin, S. Tzipori, M. Whiteway, J. Mecsas, and C. A. Kumamoto. 2007. Self-regulation of Candida albicans population size during GI colonization. PLoS Pathog. 3:e184.
54. Zhou, H., and M. C. Lorenz. 2008. Carnitine acetyltransferases are required for growth on non-fermentable carbon sources but not for pathogenesis in Candida albicans. Microbiology 154:500-509.