PKCε acts as negative allosteric modulator of EGF receptor signalling

Cellular Signalling

Volumn 23, Issue 2, 2011, Pages 436-448

  Weisheit, Simona ^a   Schäfer, Claudia ^a   Mertens, Carmen ^a   Berndt, Alexander ^b   Liebmann, Claus ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Allosteric inhibition; EGFR; HNSCC cells; PKC ; PLC 1; Signalling

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; SCAFFOLD PROTEIN; SMALL INTERFERING RNA;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHOSPHORYLATION; CANCER CELL CULTURE; CATALYSIS; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE OVEREXPRESSION; HEAD AND NECK CANCER; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; MICE; PHOSPHOLIPASE C GAMMA; PROTEIN KINASE C-EPSILON; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 78649845499     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2010.10.018     Document Type: Article

References (37)

1. Akita Y. J. Biochem. 2002, 132:847.
2. Gorin A.A., Pan Q. Mol. Cancer 2009, 8:1.
3. Basu A., Sivaprasad U. Cell. Signal. 2007, 19:1633.
4. Lu D., Sivaprasad U., Huang J., Shankar E., Morrow S., Basu A. Apoptosis 2007, 12:1893.
5. Pan Q., Bao L.W., Kleer C.G., Sabel M.S., Griffith K.A., Teknos T.N., Merajver S.D. Cancer Res. 2005, 65:8366.
6. Chu F., Koomen J.M., Kobayashi R., O'Brian C.A. Cancer Res. 2005, 65:10478.
7. Song C., Vondriska T.M., Wang G.W., Klein J.B., Cao X., Zhang J., Kang Y.J., D́Souza S., Ping P.P. Am. J. Physiol. Heart Circ. Physiol. 2002, 282:H1166.
8. Pardo O.E., Wellbrock C., Khanzada U.K., Aubert M., Arozarena I., Davidson S., Bowen F., Parker P.J., Filonenko V.V., Gout I.T., Sebire N., Marais R., Downward J., Seckl M.J. EMBO J. 2006, 25:3078.
9. Valkova C., März S., Imhof D., Liebmann C. Cell. Signal. 2007, 19:1830.
10. Hynes N.E., Mac Donald G. Curr. Opin. Cell Biol. 2009, 21:177.
11. Normanno N., De Luca A., Bianco C., Strizzi L., Mancino M., Maiello M.R., Carotenuto A., De Feo G., Caponigro F., Salomon D.S. Gene 2009, 366:2.
12. Wilson K.J., Gilmore J.L., Lemmon M.A., Riese D.J. Pharmacol. Ther. 2009, 122:1.
13. Chattopadhyay A., Vecchi M., Ji Q.-S., Mernaugh R., Carpenter G. J. Biol. Chem. 1999, 274:26091.
14. Poulin B., Sekiya F., Rhee S.G. Proc. Natl Acad. Sci. USA 2005, 4276.
15. Kalyankrishna S., Grandis J.R. J. Clin. Oncol. 2006, 24:2666.
16. Ratushny V., Astsaturov I., Burtness B.A., Golemis E.A., Silverman J.S. Cell. Signal. 2009, 21:1255.
17. Wang Z., Glück S., Zhang L., Moran M.F. Mol. Cell. Biol. 1998, 18:590.
18. Thomas S.M., Coppelli F.M., Wells A., Gooding W.E., Song J., Kassis J., Drenning S.D., Grandis J.R. Cancer Res. 2003, 63:5629.
19. Filmus J., Pollak M.N., Cailleau R., Buick R.N. Biochem. Biophys. Res. Commun. 1985, 128:898.
20. Barnes D.W. J. Cell Biol. 1982, 93:1.
21. King I., Sartorelli A.C. Cancer Res. 1989, 49:5677.
22. Wach F., Eyrich A.-M., Wustrow T., Krieg T., Hein R. J. Dermatol. Sci. 1996, 12:118.
23. Berndt A., Hyckel P., Könneker A., Katenkamp D., Kosmehl H. Invasion Metastasis 1997, 17:251.
24. Zeke A., Lukacs M., Lim W.A., Remenyi A. Trends Cell Biol. 2009, 19:364.
25. Martinez-Gimenco C., Diaz-Meco M.T., Dominguez I., Moscat J. Head Neck 1995, 17:516.
26. Kenakin T.P. Trends Pharmacol. Sci. 2009, 30:460.
27. Kenakin T.P. Trends Pharmacol. Sci. 2007, 28:407.
28. Leach K., Sexton P.M., Christopulos A. Trends Pharmacol. Sci. 2007, 28:382.
29. Wang L., Martin B., Brenneman R., Luttrell L.M., Maudsley S. J. Pharmacol. Exp. Ther. 2009, 331:340.
30. Pan Q., Bao L.W., Teknos T.N., Merajver S.D. Cancer Res. 2006, 66:9379.
31. Choi J.H., Bae S.S., Park J.B., Ha S.H., Song H., Kim J.J., Cocco L., Ryu S.H., Suh P.G. Mol. Cells 2003, 15:245.
32. Steinberg S.F. Physiol. Rev. 2008, 88:1341.
33. Conigrave A.D., Franks A.H. Prog. Biophys. Mol. Biol. 2003, 81:219.
34. Changeux J.P., Edelstein S.J. Science 2005, 308:1424.
35. del Sol A., Tsai C.-J., Ma B., Nussinov R. Structure 2009, 17:1042.
36. Gonzalez-Cestari T.F., Henderson B.J., Pavlovicz R.E., MacKay S.B., El-Hajj R.A., Pulipaka A.B., Orac C.M., Read D.D., Boyd R.T., Zhu M.X., Li C., Bergmeier S.C., McKay D.B. J. Pharmacol. Exp. Ther. 2009, 328:504.
37. Seo S., Henry J.T., Lewis A.H., Wang N., Levandoski M.M. J. Neurosci. 2009, 29:8734.