Scale-up of high-shear mixer granulators

KONA Powder and Particle Journal

Volumn 26, Issue March, 2008, Pages 190-204

  Rahmanian, Nejatollah ^a   Ng, Boon Ho ^a   Hassanpour, Ali ^a   Ding, Yu Long ^a   Antony, Joseph ^a   Jia, Xiao Dong ^a   Ghadiri, Mojtaba ^a   van der Wel, Peter G J ^b   Krug Polman, Allet ^b   York, David ^c   Bayly, Andrew ^c   Tan, Hong Sing ^c  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b HOSOKAWA MICRON CORPORATION   (Japan)

^c Procter and Gamble ^*  (United Kingdom)

Author keywords

Cyclomix; DEM modelling; Granulation; High shear granulator; PEPT; Scale up; Strength

Indexed keywords

DEFORMATION; ELASTICITY; GRANULAR MATERIALS; GRANULATION; GRANULATORS; INDUSTRIAL RESEARCH; MIXERS (MACHINERY); RESEARCH AND DEVELOPMENT MANAGEMENT; STRESSES; STRUCTURAL DESIGN;

CYCLOMIX; DEM MODELLING; HIGH-SHEAR GRANULATOR; PEPT; SCALE-UP; STRENGTH;

PARTICLES (PARTICULATE MATTER);

EID: 78649844555     PISSN: 02884534     EISSN: 21875537     Source Type: Journal    
DOI: 10.14356/kona.2008017     Document Type: Article

References (41)

1. Capes, C.E.(1980): Particle size enlargement, In Handbook of Powder Technology. Vol. 1. Elsevier, Amsterdam.
2. Pietsch, W.(1991): "Size enlargement by agglomeration", Wiley; Aarau; Salle and Sauerländer, Chichester.
3. Ennis, B. J., Litster, J. D.(1997): Principles of size enlargement. In Green D, Perry R. eds. Perry's Chemical Engineers Handbook 7th Edition. New York: Mc Graw Hill.
4. Litster, J. and Ennis, B.(2004): "The science and engineering of granulation process", Dordrecht, The Netherlands, Kluwer academic publishers.
5. Faure, P. York, R.C. and Rowe, (2001): Process control and scale-up of pharmaceutical wet granulation processes: A Review, European Journal of Pharmaceutics and Biopharmaceutics 52, pp.269-277.
6. Knight P.(2004): Challenges in granulation technology, Powder Technol. 140, pp.156-162.
7. Timothy A. B.(2005): Challenges in the scale-up of particulate processes - an industrial perspective, Powder Technol. 150, pp.60-71.
8. Mort, P. R.(2005): Scale-up of binder agglomeration processes, Powder Technol. 150, pp.86-103.
9. Newitt, D.M. and Conway-Jones, J. M.(1958): A contribution to the theory and practice of granulation, Trans. Inst. Chem Eng. 36, pp.422-441.
10. Kapur, P.C. and Fuerstenau, D.W.(1969): A coalescence model for granulation, Ind. Eng. Chem. Process Des. Dev. 8, pp.56-62.
11. Iveson, S. M., Litster, J.D. and Ennis, J.D.(1996): Fundamental studies of granule consolidation: Part 1. Effects of binder viscosity and binder content, Powder Technol. 88, pp.15-20.
12. Knight, P.C., Instone, T., Peason, J.M.K. and Hounslow, M.J.(1998): An investigation into kinetics of liquid distribution and growth in high shear mixer agglomeration, Powder Technol. 97, pp.246-257.
13. Knight, P.C., Johansen, A., Kristensen, P.C., Schaefer, P.C. and Seville, J.P.K. (2000): An investigation of the effects on agglomeration of changing the speed of a mechanical mixer, Powder Technol. 110, pp.204-209.
14. Scott, A., Hounslow, M.J. and Instone, T.(2000): Direct evidence of heterogeneity during high shear granulation, Powder Technol. 113, pp.205-213.
15. Johansen, A. and Schaefer, T.(2001): Effects of interactions between powder particle size and binder viscosity on agglomerate growth mechanisms in a high shear mixer, Eur. J. Pharm. Sci. 12, pp.297-309.
16. Faure, A., Grimsey, I. M, Rowe, R.C., York, P. and Cliff, M.J.(1998): A methodology for the optimization of wet granulation in a model planetary mixer, Pharm. Dev. Technology 3, pp.413-422.
17. Bock, T K. and Kraas (2001): Experience with the Diosna mini-granulator and assessment of process scalability, European Journal of Pharmaceutics and Biopharmaceutics 52, pp.97-303.
18. Horsthuis G.J.B., van Larrhoven J. A. H, van Rooij R. C. B. M. and Vormans H. (1993): Studies on up scaling parameters of the Gral high-shear granulation process, Int. J. Pharm. 92, pp.143-150.
19. Tardos G.I, Irfan Khan, M. and Mort, P.M.(1997): Critical parameters and limiting conditions in binder granulation of fine powders, Powder Technol. 94, pp.245-258.
20. Tardos, G.I., Hapgood, K.P., Ipadeola, O.O. and Michaels, J.N.(2004): Stress measurements in high-shear granulators using calibrated "test" particles: application to scale-up, Powder Technol. 140, pp.217-227.
21. Subero, J. And Ghadiri, M.(2001): Breakage patterns of agglomerates, Powder Technol. 120 (3), pp.232-243.
22. Salman, A.D., Fu, J., Gorham, A. D. and Hounslow, M.J.(2003): Impact breakage of fertiliser granules. Powder Technol. 130 (1-3), pp.359-366.
23. Golchert, D., Moreno, R., Ghadiri, M. and Litster, J.(2004): Effect of granule morphology on breakage behaviour during compression, Powder Technol. 143-144, pp.84-96.
24. Antonyuk, S., Khanal, M., Tomas, J., Heinrich, S. and Mörl, L.(2006): Impact breakage of spherical granules: experimental study and DEM simulation, Chemical Engineering and Processing 45 (10), pp.838-856.
25. Hassanpour, A., Antony, S.J. and Ghadiri, M.(2007): Effect of size ratio on the behaviour of agglomerates embedded in a bed of particles subjected to shearing - DEM analysis, Chem. Eng. Sci. 62, pp.935-942.
26. Parker, J., Hawkesworth, M.R., Broadbent, C.J., Fowles, P., Fryer, T. D. and McNeil, P. (1994): Industrial positron-based imaging: principles and applications, Nuclear Instruments and Methods in Physics Research A, 348, pp.583-592.
27. Parker, D. J., Dijkstra, A.E., Martin, I.T.W and Seville, J. P. K. (1997): Positron emission particle tracking studies of spherical particle motion in rotating drums, Chemical Engineering Science, 52(13), pp.2011-2022.
28. Parker, D. J., Forster, R.N, Fowles, P. and Takhar, P.S.(2002): Positron emission particle tracking using the new Birmingham positron camera, Nuclear Instruments and Methods in Physics Research A, 477, 540-545.
29. Kwan, C. C., Hare, C., Ding, Y., Williams, R.A. and Ghadiri, M.(2006): How granule characteristics change when high shear mixer granulator are scaleup, Fifth World Congress on Particle Technology, 23-27 April, Florida, USA.
30. Eliassi, A., Modarres, H. and Mansoori, G.A.(1998): Densities of Polyethyleneglycol and water mixtures in the 298.15-328.15K temperature range, J. Chem. Eng. Data, 43, pp.719-721.
31. Kwan, C.C., Ding, Y., Williams, R. A. and Ghadiri, M.(2005): Effects of operating parameters of high shear granulator on the evolved properties and structure of calcium carbonate granules, in Particular Systems Analysis Stratford-upon-Avon, UK.
32. Rahmanian, N., Ghadiri, M., Ding, Y. and Jia X.(2007): Influence of scale-up of high shear mixer granulators on the strength and properties of granules, PARTEC 2007, P06-03 27-29 March, Nuremberg, Germany.
33. Rahmanian, N., Ghadiri, M. and Ding, Y. (2008): Effect of scale of operation on granule strength in high shear granulators, Chem. Eng. Sci., 63 (4), pp.915-923.
34. Cundall, P. A.(1971): A computer model for simulating progressive, large-scale movements in blocky rock systems, Proc. Symp. Int. Soc. Rock Mech., Nancy 2, 8.
35. Cundall, P.A. and Strack, O.D.L.(1979): A discrete numerical model for granular assemblies, Geotechnique 29, pp.47-65.
36. Thornton, C., and Yin, K.K.(1991): Impact of elastic sphere with and without adhesion, Powder Technol. 65, pp.153-166.
37. Hooijmaijers, R., Oostra, W. and van den Dries, K. (2007): An investigation of upscaling factors in high shear granulation, International Congress on Particle Technology, PARTEC 2007, S05-1 27-29 March 2007, Nuremberg, Germnay.
38. Ng, B. H., Kwan, C.C., Ding, Y. L. Ghadiri, M. and Fan, X.F.(2007): Solids motion in a conical frustumshaped high shear mixer granulator, Chem. Eng. Sci. 62, pp.756-765.
39. Hassanpour, A., Kwan, C.C., Ng, B.H., Rahmanian, N., Ding, Y.L., Antony, Y.L., Jia, Y.L. and Ghadiri, M. (2008): Effect of granulation scale-up on the structure and strength of granules, in print, Powder Technol., doi: 10.1016.
40. Rumpf, H.(1962): The strength of granules and agglomerates, In Agglomeration (ed. W.A. Knepper), Proceedings of the First International Symposium on Agglomeration, Philadelphia. John Wiley and Sons, New York/London, pp.379-418.
41. Kendall, K. (1988): Agglomerate strength, Powder Metallurgy, 31 (1), pp.28-31.