Catestatin in rat RVLM is sympathoexcitatory, increases barosensitivity, and attenuates chemosensitivity and the somatosympathetic reflex

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 299, Issue 6, 2010, Pages

  Gaede, Andrea H ^a   Pilowsky, Paul M ^a  

^a MACQUARIE UNIVERSITY   (Australia)

Author keywords

Baroreflex; Chromogranin A; Hypoxic chemoreflex; Sprague Dawley rat

Indexed keywords

CATESTATIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BAROSENSITIVITY; BLOOD PRESSURE; CARDIOVASCULAR RESPONSE; CHEMOSENSITIVITY; CONTROLLED STUDY; ENZYME LOCALIZATION; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; NERVE CELL; NERVE CELL STIMULATION; NERVE CONDUCTION; NONHUMAN; PHRENIC NERVE; PHYSICAL SENSITIVITY; PRESSORECEPTOR; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; ROSTRAL VENTROLATERAL MEDULLA; SCIATIC NERVE; SOMATOSYMPATHETIC REFLEX; SYMPATHETIC NERVE; SYMPATHETIC REFLEX;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD PRESSURE; CHEMORECEPTOR CELLS; CHROMOGRANIN A; FLUORESCENT ANTIBODY TECHNIQUE; HEART RATE; MEDULLA OBLONGATA; NEURONS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; REFLEX; SYMPATHETIC NERVOUS SYSTEM; TYROSINE 3-MONOOXYGENASE;

EID: 78649829884     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00335.2010     Document Type: Article

References (46)

1. Aardal S, Helle KB, Elsayed S, Reed RK, Serck-Hanssen G. Vasostatins, comprising the N-terminal domain of chromogranin A, suppress tension in isolated human blood vessel segments. J Neuroendocrinol 5: 405-412, 1993.
2. Abbott SB, Pilowsky PM. Galanin microinjection into rostral ventrolateral medulla of the rat is hypotensive and attenuates sympathetic chemore- flex. Am J Physiol Regul Integr Comp Physiol 296: R1019-R1026, 2009.
3. Angeletti RH, Aardal S, Serck-Hanssen G, Gee P, Helle KB. Vasoinhibitory activity of synthetic peptides from the amino terminus of chromogranin A. Acta Physiol Scand 152: 11-19, 1994.
4. Azaryan AV, Krieger TJ, Hook VYH. Purification and characteristics of the candidate prohormone processing proteases PC2 and PC1/3 from bovine adrenal medulla chromaffin granules. J Biol Chem 270: 8201-8208, 1995.
5. Biswas N, Rodriguez-Flores JL, Courel M, Gayen JR, Vaingankar SM, Mahata M, Torpey JW, Taupenot L, O'Connor DT, Mahata SK. Cathepsin L colocalizes with chromogranin A in chromaffin vesicles to generate active peptides. Endocrinology 150: 3547-3557, 2009.
6. Brooks NA, Pouniotis DS, Tang CK, Apostolopoulos V, Pietersz GA. Cell-penetrating peptides: application in vaccine delivery. Biochim Biophys Acta 1805: 25-34, 2010.
7. Burke PGR, Li Q, Costin ML, McMullan S, Pilowsky PM, Goodchild AK. Somatostatin 2A receptor-expressing presympathetic neurons in the rostral ventrolateral medulla maintain blood pressure. Hypertension 52: 1127-1133, 2008.
8. Gaede AH, Lung MS, Pilowsky PM. Catestatin attenuates the effects of intrathecal nicotine and isoproterenol. Brain Res 1305: 86-95, 2009.
9. Gayen JR, Gu Y, O'Connor DT, Mahata SK. Global disturbances in autonomic function yield cardiovascular instability and hypertension in the chromogranin A null mouse. Endocrinology 150: 5027-5035, 2009.
10. Helle KB, Corti A, Metz-Boutigue MH, Tota B. The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties. Cell Mol Life Sci 64: 2863-2886, 2007.
11. Huangfu D, Schreihofer M, Guyenet PG. Effect of cholinergic agonists on bulbospinal C1 neurons in rats. Am J Physiol Regul Integr Comp Physiol 272: R249-R258, 1997. (Pubitemid 127750121)
12. Kanjhan R, Lipski J, Kruszewska B, Rong W. A comparative study of pre-sympathetic and Botzinger neurons in the rostral ventrolateral medulla (RVLM) of the rat. Brain Res 699: 19-32, 1995.
13. Kashihara K, McMullan S, Lonergan T, Goodchild AK, Pilowsky PM. Neuropeptide Y in the rostral ventrolateral medulla blocks somatosympathetic reflexes in anesthetized rats. Auton Neurosci 142: 64-70, 2008.
14. Kennedy BP, Mahata SK, O'Connor DT, Ziegler MG. Mechanism of cardiovascular actions of the chromogranin A fragment catestatin in vivo. Peptides 19: 1241-1248, 1998.
15. Krassioukov AV, Munoz DG, Yang JP, Weaver LC. Effect of chromogranin A on central autonomic control of blood pressure. J Auton Nerv Syst 50: 61-71, 1994.
16. Li Q, Goodchild AK, Seyedabadi M, Pilowsky PM. Pre-protachykinin A mRNA is colocalized with tyrosine hydroxylase-immunoreactivity in bulbospinal neurons. Neuroscience 136: 205-216, 2005.
17. Lipski J, Bellingham MC, West MJ, Pilowsky P. Limitations of the technique of pressure microinjection of excitatory amino acid for evoking responses from localized regions of the CNS. J Neurosci Methods 26: 169-179, 1988.
18. Lipski J, Kanjhan R, Kruszewska B, Rong WF. Criteria for intracellular identification of pre-sympathetic neurons in the rostral ventrolateral medulla in the rat. Clin Exp Hypertens 17: 51-65, 1995.
19. Machado BH, Bonagamba LGH, Dun SL, Kwok EH, Dun NJ. Pressor response to microinjection of orexin/hypocretin into rostral ventrolateral medulla of awake rats. Regul Pept 104: 75-81, 2002.
20. Mahata SK, Mahata M, Fung MM, O'Connor DT. Catestatin: a multifunctional peptide from chromogranin A. Regul Pept 162: 33-43, 2010.
21. Mahata SK, Mahata M, Wakade AR, O'Connor DT. Primary structure and function of the catecholamine release inhibitory peptide catestatin [chromogranin A(344-364)]: identification of amino acid residues crucial for activity. Mol Endocrinol 14: 1525-1535, 2000.
22. Mahata SK, Mahata M, Wen G, Wong WB, Mahapatra NR, Hamilton BA, O'Connor DT. The catecholamine release-inhibitory "catestatin" fragment of chromogranin A: naturally occurring human variants with different potencies for multiple chromaffin cell nicotinic cholinergic responses. Mol Pharmacol 66: 1180-1191, 2004.
23. Mahata SK, O'Connor DT, Mahata M, Yoo SH, Taupenot L, Wu H, Gill BM, Parmer RJ. Novel autocrine feedback control of catecholamine release. A discrete chromogranin A fragment is a noncompetitive nicotinic cholinergic antagonist. J Clin Invest 100: 1623-1633, 1997.
24. Makeham JM, Goodchild AK, Pilowsky PM. NK1 receptor activation in rat rostral ventrolateral medulla selectively attenuates somato-sympathetic reflex while antagonism attenuates sympathetic chemoreflex. Am J Physiol Regul Integr Comp Physiol 288: R1707-R1715, 2005.
25. Mazza R, Gattuso A, Mannarino C, Brar BK, Barbieri SF, Tota B, Mahata SK. Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart. Am J Physiol Heart Circ Physiol 295: H113-H122, 2008.
26. McAuley MA, Macrae IM, Reid JL. The cardiovascular actions of clonidine and neuropeptide-Y in the ventrolateral medulla of the rat. Br J Pharmacol 97: 1067-1074, 1989.
27. McMullan S, Goodchild AK, Pilowsky PM. Circulating angiotensin II attenuates the sympathetic baroreflex by reducing the barosensitivity of medullary cardiovascular neurones in the rat. J Physiol 582: 711-722, 2007.
28. McMullan S, Pathmanandavel K, Pilowsky PM, Goodchild AK. Somatic nerve stimulation evokes qualitatively different somatosympathetic responses in the cervical and splanchnic sympathetic nerves in the rat. Brain Res 1217: 139-147, 2008.
29. 1A receptors selectively inhibit the somatosympathetic reflex. Am J Physiol Regul Integr Comp Physiol 280: R1261-R1268, 2001.
30. Moon EA, Goodchild AK, Pilowsky PM. Lateralisation of projections from the rostral ventrolateral medulla to sympathetic preganglionic neurons in the rat. Brain Res 929: 181-190, 2002.
31. Morrison SF, Reis DJ. Reticulospinal vasomotor neurons in the RVL mediate the somatosympathetic reflex. Am J Physiol Regul Integr Comp Physiol 256: R1084-R1097, 1989.
32. Oshima N, Kumagai H, Onimaru H, Kawai A, Pilowsky PM, Iigaya K, Takimoto C, Hayashi K, Saruta T, Itoh H. Monosynaptic excitatory connection from the rostral ventrolateral medulla to sympathetic preganglionic neurons revealed by simultaneous recordings. Hypertens Res 31: 1445-1454, 2008.
33. Padley JR, Kumar NN, Li Q, Nguyen TB, Pilowsky PM, Goodchild AK. Central command regulation of circulatory function mediated by descending pontine cholinergic inputs to sympathoexcitatory rostral ventrolateral medulla neurons. Circ Res 100: 284-291, 2007.
34. Pilowsky PM, Abbott SB, Burke PG, Farnham MM, Hildreth CM, Kumar NN, Li Q, Lonergan T, McMullan S, Spirovski D, Goodchild AK. Metabotropic neurotransmission and integration of sympathetic nerve activity by the rostral ventrolateral medulla in the rat. Clin Exp Pharmacol Physiol 35: 508-511, 2008.
35. Pilowsky PM, Goodchild AK. Baroreceptor reflex pathways and neurotransmitters: 10 years on. J Hypertens 20: 1675-1688, 2002.
36. Pilowsky PM, Jiang C, Lipski J. An intracellular study of respiratory neurons in the rostral ventrolateral medulla of the rat and their relationship to catecholamine-containing neurons. J Comp Neurol 301: 604-617, 1990.
37. Pilowsky PM, Lung MS, Spirovski D, McMullan S. Differential regulation of the central neural cardiorespiratory system by metabotropic neurotransmitters. Philos Trans R Soc Lond B Biol Sci 364: 2537-2552, 2009.
38. 364Ser causes profound changes in human autonomic activity and alters risk for hypertension. Circulation 115: 2271-2281, 2007.
39. Russell J, Gee P, Liu SM, Angeletti RH. Inhibition of parathyroid hormone secretion by amino-terminal chromogranin peptides. Endocrinology 135: 337-342, 1994.
40. Smani T, Zakharov SI, Csutora P, Leno E, Trepakova ES, Bolotina VM. A novel mechanism for the store-operated calcium influx pathway. Nat Cell Biol 6: 113-120, 2004.
41. Somogyi P, Hodgson AJ, DePotter RW, Fischer-Colbrie R, Schober M, Winkler H, Chubb IW. Chromogranin immunoreactivity in the central nervous system. Immunochemical characterisation, distribution and relationship to catecholamine and enkephalin pathways. Brain Res 320: 193-230, 1984.
42. Sugawara M, Resende JM, Moraes CM, Marquette A, Chich JF, Metz-Boutigue MH, Bechinger B. Membrane structure and interactions of human catestatin by multidimensional solution and solid-state NMR spectroscopy. FASEB J 24: 1737-1746, 2010.
43. Tatemoto K, Efendic S, Mutt V, Makk G, Feistner GJ, Barchas JD. Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Nature 324: 476-478, 1986.
44. Tseng CJ, Appalsamy M, Robertson D, Mosqueda-Garcia R. Effects of nicotine on brain stem mechanisms of cardiovascular control. J Pharmacol Exp Ther 265: 1511-1518, 1993. (Pubitemid 23321059)
45. Winkler H, Fischer-Colbrie R. The chromogranins A and B: the first 25 years and future perspectives. Neuroscience 49: 497-528, 1992.
46. 2. PLoS ONE 4, 2009.