Circulating angiotensin II attenuates the sympathetic baroreflex by reducing the barosensitivity of medullary cardiovascular neurones in the rat

Journal of Physiology

Volumn 582, Issue 2, 2007, Pages 711-722

  McMullan, Simon ^a,b   Goodchild, Ann K ^a,b   Pilowsky, Paul M ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b MACQUARIE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; PHENYLEPHRINE;

ANIMAL EXPERIMENT; AORTA NERVE; ARTERIAL PRESSURE; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; ELECTROSTIMULATION; MALE; MEDULLA OBLONGATA; NERVE CELL MEMBRANE POTENTIAL; NERVE CONDUCTION; NEUROMUSCULAR BLOCKING; NONHUMAN; PHYSICAL SENSITIVITY; PRESSORECEPTOR; PRESSORECEPTOR REFLEX; PRESSURE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SYMPATHETIC NERVE; SYMPATHETIC REFLEX; VASOCONSTRICTION; ANGIOTENSIN BLOOD LEVEL; ANGIOTENSIN II BLOOD LEVEL; ANIMAL CELL; ANIMAL TISSUE; AORTIC DEPRESSOR NERVE; CARDIOVASCULAR FUNCTION; CIRCUMVENTRICULAR ORGAN; EVOKED RESPONSE; EXPERIMENTAL STUDY; HORMONE ACTION; MEDULLARY CARDIOVASCULAR NERVE CELL BAROSENSITIVITY; NERVE CELL; NERVE STIMULATION; NERVOUS SYSTEM PARAMETERS; ROSTRAL VENTROLATERAL MEDULLA; SPLANCHNIC NERVE; SYMPATHETIC TONE;

ANGIOTENSIN II; ANIMALS; AORTA; BAROREFLEX; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; INJECTIONS, INTRAVENOUS; MALE; MEDULLA OBLONGATA; NERVOUS SYSTEM PHYSIOLOGY; NEURAL INHIBITION; NEURONS; PHENYLEPHRINE; PRESSORECEPTORS; RATS; RATS, SPRAGUE-DAWLEY; SPLANCHNIC NERVES; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 34447285993     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.128983     Document Type: Article

References (63)

1. Allen AM, Moeller I, Jenkins TA, Zhuo J, Aldred GP, Chai SY & Mendelsohn FA (1998). Angiotensin receptors in the nervous system. Brain Res Bull 47, 17-28.
2. Badoer E & Merolli J (1998). Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are activated by haemorrhage. Brain Res 791, 317-320.
3. Bains JS & Ferguson AV (1995). Paraventricular nucleus neurons projecting to the spinal cord receive excitatory input from the subfornical organ. Am J Physiol Regul Integr Comp Physiol 268, R625-R633.
4. Bishop VS & Hay M (1993). Involvement of the area postrema in the regulation of sympathetic outflow to the cardiovascular-system. Front Neuroendocrinol 14, 57-75.
5. Bonham AC & Hasser EM (1993). Area postrema and aortic or vagal afferents converge to excite cells in nucleus-tractus-solitarius. Am J Physiol Heart Circ Physiol 264, H1674-H1685.
6. Brown DL & Guyenet PG (1984). Cardiovascular neurons of brain stem with projections to spinal cord. Am J Physiol Regul Integr Comp Physiol 247, R1009-R1016.
7. Brown AM, Saum WR & Yasui S (1978). Baroreceptor dynamics and their relationship to afferent fiber type and hypertension. Circ Res 42, 694-702.
8. Cai Y, Hay M & Bishop VS (1994). Stimulation of area postrema by vasopressin and angiotensin II modulates neuronal activity in the nucleus tractus solitarius. Brain Res 647, 242-248.
9. Carpenter DO, Briggs DB & Strominger N (1983). Responses of neurons of canine area postrema to neurotransmitters and peptides. Cell Mol Neurobiol 3, 113-126.
10. Casto R & Phillips MI (1986). Angiotensin II attenuates baroreflexes at nucleus tractus solitarius of rats. Am J Physiol Regul Integr Comp Physiol 250, R193-R198.
11. Coote JH, Yang Z, Pyner S & Deering J (1998). Control of sympathetic outflows by the hypothalamic paraventricular nucleus. Clin Exp Pharmacol Physiol 25, 461-463.
12. Cunningham ET Jr, Bohn MC & Sawchenko PE (1990). Organization of adrenergic inputs to the paraventricular and supraoptic nuclei of the hypothalamus in the rat. J Comp Neurol 292, 651-667.
13. Dawson CA, Jhamandas JH & Krukoff TL (1998). Activation by systemic angiotensin II of neurochemically identified neurons in rat hypothalamic paraventricular nucleus. J Neuroendocrinol 10, 453-459.
14. Diehl KH, Hull R, Morton D, Pfister R, Rabemampianina Y, Smith D, Vidal JM & van de Vorstenbosch C (2001). A good practice guide to the administration of substances and removal of blood, including routes and volumes. J Appl Toxicol 21, 15-23.
15. Fang X, McMullan S, Lawson SN & Djouhri L (2005). Electrophysiological differences between nociceptive and non-nociceptive dorsal root ganglion neurones in the rat in vivo. J Physiol 565, 927-943.
16. Felix D & Akert K (1974). The effect of angiotensin II on neurones of the cat subfornical organ. Brain Res 76, 350-353.
17. Ferguson AV (1988). Paraventricular nucleus neurons projecting to the dorsomedial medulla are influenced by systemic angiotensin. Brain Res Bull 20, 197-201.
18. Ferguson AV & Bains JS (1996). Electrophysiology of the circumventricular organs. Front Neuroendocrinol 17, 440-475.
19. Fukiyama K (1972). Central action of angiotensin and hypertension - increased central vasomotor outflow by angiotensin. Jpn Circ J 36, 599-602.
20. Gorbea-Oppliger VJ & Fink GD (1994). Clonidine reverses the slowly developing hypertension produced by low doses of angiotensin II. Hypertension 23, 844-847.
21. Guo GB & Abboud FM (1984). Angiotensin II attenuates baroreflex control of heart rate and sympathetic activity. Am J Physiol Heart Circ Physiol 246, H80-H89.
22. 125I]Sar1,Ile8-Angiotensin II to move between the blood and cerebrospinal fluid compartments. J Neurochem 50, 554-557.
23. Hay M & Bishop VS (1991). Interactions of area postrema and solitary tract in the nucleus tractus solitarius. Am J Physiol Heart Circ Physiol 260, H1466-H1473.
24. Herman JP & Cullinan WE (1997). Neurocircuitry of stress: Central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci 20, 78-84.
25. Johansson BB & Linder LE (1978). Reversibility of the blood-brain barrier dysfunction induced by acute hypertension. Acta Neurol Scand 57, 345-348.
26. Joy MD & Lowe RD (1970). Evidence that the area postrema mediates the central cardiovascular response to angiotensin II. Nature 228, 1303-1304.
27. Koganezawa T & Terui N (2006). Differential responsiveness of RVLM sympathetic premotor neurons to hypoxia in rabbits. Am J Physiol Heart Circ Physiol 292, H408-H414.
28. Kumagai K & Reid IA (1994). Angiotensin II exerts differential actions on renal nerve activity and heart rate. Hypertension 24, 451-456.
29. LaGrange LP, Toney GM & Bishop VS (2003). Effect of intravenous angiotensin II infusion on responses to hypothalamic PVN injection of bicuculline. Hypertension 42, 1124-1129.
30. Li Q, Sullivan MJ, Dale WE, Hasser EM, Blaine EH & Cunningham JT (1998). Fos-like immunoreactivity in the medulla after acute and chronic angiotensin II infusion. J Pharmacol Exp Ther 284, 1165-1173.
31. Lidierth M (2005). Pulser: User-friendly, graphical user-interface based software for controlling stimuli during data acquisition with Spike2 for Windows. J Neurosci Methods 141, 243-250.
32. Lipski J (1981). Antidromic activation of neurons as an analytic tool in the study of the central nervous system. J Neurosci Methods 4, 1-32.
33. Lohmeier TE, Lohmeier JR, Warren S, May PJ & Cunningham JT (2002). Sustained activation of the central baroreceptor pathway in angiotensin hypertension. Hypertension 39, 550-556.
34. Lumbers ER, McCloskey DI & Potter EK (1979). Inhibition by angiotensin II of baroreceptor-evoked activity in cardiac vagal efferent nerves in the dog. J Physiol 294, 69-80.
35. Lynn B & Carpenter SE (1982). Primary afferent units from the hairy skin of the rat hindlimb. Brain Res 238, 29-43.
36. McCloskey CA, Zuckerbraun BS, Gallo DJ, Vodovotz Y & Billiar TR (2003). A role for angiotensin II in the activation of extracellular signal-regulated kinases in the liver during hemorrhagic shock. Shock 20, 316-319.
37. McKinley MJ, McAllen RM, Davern P, Giles ME, Penschow J, Sunn N, Uschakov A & Oldfield BJ (2003). The sensory circumventricular organs of the mammalian brain - subfornical organ, OVLT and area postrema - Introduction. In Sensory Circumventricular Organs of the Mammalian Brain, Springer, pp. Springer 55-67.
38. Makeham JM, Goodchild AK, Costin NS & Pilowsky PM (2004). Hypercapnia selectively attenuates the somato-sympathetic reflex. Resp Physiol Neurobiol 140, 133-143.
39. Matsukawa T, Gotoh E, Minamisawa K, Kihara M, Ueda S, Shionoiri H & Ishii M (1991). Effects of intravenous infusions of angiotensin II on muscle sympathetic nerve activity in humans. Am J Physiol Regul Integr Comp Physiol 261, R690-R696.
40. Matsumura Y, Hasser EM & Bishop VS (1989). Central effect of angiotensin II on baroreflex regulation in conscious rabbits. Am J Physiol Regul Integr Comp Physiol 256, R694-R700.
41. Mayhan WG, Faraci FM & Heistad DD (1986). Disruption of the blood-brain barrier in cerebrum and brain stem during acute hypertension. Am J Physiol Heart Circ Physiol 251, H1171-H1175.
42. Miyawaki T, Pilowsky P, Sun QJ, Minson J, Suzuki S, Arnolda L, Llewellyn-Smith I & Chalmers J (1995). Central inspiration increases barosensitivity of neurons in rat rostral ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol 268, R909-R918.
43. Morrison SF (2001). Differential control of sympathetic outflow. Am J Physiol Regul Integr Comp Physiol 281, R683-R698.
44. Morrison SF & Cao WH (2000). Different adrenal sympathetic preganglionic neurons regulate epinephrine and norepinephrine secretion. Am J Physiol Regul Integr Comp Physiol 279, R1763-R1775.
45. Nahey D & Collister JP (2006). ANG II-induced hypertension and the role of the area postrema during normal and increased dietary salt. Am J Physiol Heart Circ Physiol 292, H694-700.
46. Oster P, Hackenth E & Hepp R (1973). Radioimmunoassay of angiotensin II in rat plasma. Experientia 29, 353-354.
47. Papas S & Ferguson AV (1991). Electrophysiological evidence of baroreceptor input to area postrema. Am J Physiol Regul Integr Comp Physiol 261, R9-R13.
48. Papas S, Smith P & Ferguson AV (1990). Electrophysiological evidence that systemic angiotensin influences rat area postrema neurons. Am J Physiol Regul Integr Comp Physiol 258, R70-R76.
49. Paton JF, Lonergan T, Deuchars J, James PE & Kasparov S (2006). Detection of angiotensin II mediated nitric oxide release within the nucleus of the solitary tract using electron-paramagnetic resonance (EPR) spectroscopy. Auton Neurosci 126-127, 193-201.
50. Pilowsky PM, Jiang C & Lipski J (1990). An intracellular study of respiratory neurons in the rostral ventrolateral medulla of the rat and their relationship to catecholamine-containing neurons. J Comp Neurol 301, 604-617.
51. Potts PD, Hirooka Y & Dampney RA (1999). Activation of brain neurons by circulating angiotensin II: Direct effects and baroreceptor-mediated secondary effects. Neuroscience 90, 581-594.
52. Schadt JC & Gaddis RR (1990). Renin-angiotensin system and opioids during acute hemorrhage in conscious rabbits. Am J Physiol Regul Integr Comp Physiol 258, R543-R551.
53. Shi L, Yao J, Stewart L & Xu Z (2004). Brain C-FOS expression and pressor responses after I.V. or I.C.V. angiotensin in the near-term ovine fetus. Neuroscience 126, 979-987.
54. Sim MK & Qui XS (2003). Angiotensins in plasma of hypertensive rats and human. Regul Pept 111, 179-182.
55. Stocker SD & Toney GM (2005). Median preoptic neurones projecting to the hypothalamic paraventricular nucleus respond to osmotic, circulating Ang II and baroreceptor input in the rat. J Physiol 568, 599-615.
56. Sun MK & Spyer KM (1991). GABA-mediated inhibition of medullary vasomotor neurones by area postrema stimulation in rats. J Physiol 436, 669-684.
57. 1 receptors mediate excitatory inputs to rostral ventrolateral medulla pressor neurons from hypothalamus. Hypertension 34, 1301-1307.
58. Tanaka J, Kaba H, Saito H & Seto K (1985). Subfornical organ neurons with efferent projections to the hypothalamic paraventricular nucleus: an electrophysiological study in the rat. Brain Res 346, 151-154.
59. Thoren P, Munch PA & Brown AM (1999). Mechanisms for activation of aortic baroreceptor C-fibres in rabbits and rats. Acta Physiol Scand 166, 167-174.
60. Verberne AJ, Stornetta RL & Guyenet PG (1999). Properties of C1 and other ventrolateral medullary neurones with hypothalamic projections in the rat. J Physiol 517, 477-494.
61. Wilson CG & Bonham AC (1994). Area postrema excites and inhibits sympathetic-related neurons in rostral ventrolateral medulla in rabbit. Am J Physiol Heart Circ Physiol 266, H1075-H1086.
62. Wong J, Chou L & Reid IA (1993). Role of AT1 receptors in the resetting of the baroreflex control of heart rate by angiotensin II in the rabbit. J Clin Invest 91, 1516-1520.
63. Xu L & Sved AF (2002). Acute sympathoexcitatory action of angiotensin II in conscious baroreceptor-denervated rats. Am J Physiol Regul Integr Comp Physiol 283, R451-R459.