Effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 6, 2010, Pages

  Myles, Rachel C ^a   Bernus, Olivier ^b   Burton, Francis L ^a   Cobbe, Stuart M ^a   Smith, Godfrey L ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Action potential remodeling; Electrophysiology

Indexed keywords

ANIMAL TISSUE; ARTICLE; COMPUTER SIMULATION; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; ENDOCARDIUM; EPICARDIUM; HEART MUSCLE; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART STIMULATION; HEART VENTRICLE WALL; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ACTION POTENTIALS; ANIMALS; CARBENOXOLONE; CARDIAC PACING, ARTIFICIAL; CELL COMMUNICATION; COMPUTER SIMULATION; HEART VENTRICLES; MALE; MODELS, CARDIOVASCULAR; MYOCARDIUM; OLIGOPEPTIDES; PERFUSION; RABBITS; TIME FACTORS;

EID: 78649741301     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00518.2010     Document Type: Article

References (52)

1. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, Di Diego JM, Gintant GA, Lui DW. Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M-cells. Circ Res 69: 1427-1449, 1991.
2. Antzelevitch C, Shimizu W, Yan GX, Sicouri S, Weissenburger J, Nesterenko VV, Burashnikov A, Di Diego J, Saffitz J, Thomas GP. The M-cell: its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol 10: 1124-1152, 1999.
3. Bernus O, Wellner M, Mironov SF, Pertsov AM. Simulation of voltage-sensitive optical signals in three-dimensional slabs of cardiac tissue: application to transillumination and coaxial imaging methods. Phys Med Biol 50: 215-229, 2005.
4. Bishop MJ, Gavaghan DJ, Trayanova NA, Rodriguez B. Photon scattering effects in optical mapping of propagation and arrhythmogenesis in the heart. J Electrocardiol 40, Suppl 6: S75-S80, 2007.
5. Chauhan VS, Downar E, Nanthakumar K, Parker JD, Ross HJ, Chan W, Picton P. Increased ventricular repolarization heterogeneity in patients with ventricular arrhythmia vulnerability and cardiomyopathy. Am J Physiol Heart Circ Physiol 290: H79-H86, 2006.
6. 2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome. J Physiol 543: 615-631, 2002.
7. Cohen I, Giles W, Noble D. Cellular basis for the T-wave of the electrocardiogram. Nature 262: 657-661, 1976.
8. Colli Franzone P, Pavarino LF, Taccardi B. Simulating patterns of excitation, repolarization and action potential duration with cardiac Bidomain and Monodomain models. Math Biosci 197: 35-66, 2005.
9. Dilly KW, Rossow CF, Votaw VS, Meabon JS, Cabarrus JL, Santana LF. Mechanisms underlying variations in excitation-contraction coupling across the mouse left ventricular free wall. J Physiol 572: 227-241, 2006.
10. Drouin E, Charpentier F, Gauthier C, Laurent K, Le Marec H. Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M-cells. J Am Coll Cardiol 26: 185-192, 1995.
11. Efimov IR, Huang DT, Rendt JM, Salama G. Optical mapping of repolarization and refractoriness from intact hearts. Circulation 90: 1469-1480, 1994.
12. i-overloaded cardiac myocytes: a simulation study. Biophys J 78: 2392-2404, 2000.
13. Fedida D, Giles WR. Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle. J Physiol 442: 191-209, 1991.
14. Fish JM, Di Diego JM, Nesterenko V, Antzelevitch C. Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing. Circulation 109: 2136-2142, 2004.
15. Franz MR, Bargheer K, Rafflenbeul W, Haverich A, Lichtlen PR. Monophasic action potential mapping in human subjects with normal electrocardiograms: direct evidence for the genesis of the T-wave. Circulation 75: 379-386, 1987.
16. Franz MR, Swerdlow CD, Liem LB, Schaefer J. Cycle length dependence of human action potential duration in vivo. J Clin Invest 82: 972-979, 1988.
17. Furukawa Y, Miyazaki T, Miyoshi S, Moritani K, Ogawa S. Anisotropic conduction prolongs ventricular repolarization and increases its spatial gradient in the intact canine heart. Jpn Circ J 64: 287-294, 2000.
18. Girouard SD, Laurita KR, Rosenbaum DS. Unique properties of cardiac action potentials recorded with voltage-sensitive dyes. J Cardiovasc Electrophysiol 7: 1024-1038, 1996.
19. Glukhov AV, Fedorov VV, Lou Q, Ravikumar VK, Kalish PW, Schuessler RB, Moazami N, Efimov IR. Transmural dispersion of repolarization in failing and nonfailing human ventricle. Circ Res 106: 981-991, 2010.
20. Gotoh M, Uchida T, Mandel WJ, Fishbein MC, Chen PS, Karagueuzian HS. Cellular graded responses and ventricular vulnerability to reentry by a premature stimulus in isolated canine ventricle. Circulation 95: 2141-2154, 1997.
21. Hanson B, Sutton P, Elameri N, Gray M, Critchley H, Gill JS, Taggart P. Interaction of activation-repolarization coupling and restitution properties in humans. Circ Arrhythmia Electrophysiol 2: 162-170, 2009.
22. Hyatt CJ, Zemlin CW, Smith RM, Matiukas A, Pertsov AM, Bernus O. Reconstructing subsurface electrical wave orientation from cardiac epi-fluorescence recordings: Monte Carlo vs. diffusion approximation. Opt Express 16: 13758-13772, 2008.
23. Janse MJ, Sosunov EA, Coronel R, Opthof T, Anyukhovsky EP, de Bakker JM, Plotnikov AN, Shlapakova IN, Danilo P Jr, Tijssen JG, Rosen MR. Repolarization gradients in the canine left ventricle before and after the induction of short-term cardiac memory. Circulation 112: 1711-1718, 2005.
24. Kettlewell S, Walker NL, Cobbe SM, Burton FL, Smith GL. The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytocholasin-D in the Langendorff perfused rabbit heart. Exp Physiol 89: 163-172, 2003.
25. Libbus I, Rosenbaum DS. Transmural action potential changes underlying ventricular electrical remodelling. J Cardiovasc Electrophysiol 14: 394-402, 2002.
26. 2+ in left ventricular myocyte sub-types from rabbits with heart failure. Cardiovasc Res 45: 397-409, 2000.
27. Medina-Ravell VA, Lankipalli RS, Yan GX, Antzelevitch C, Medina-Malpica NA, Medina-Malpica OA, Droogan C, Kowey PR. Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization. Circulation 107: 740-746, 2003.
28. Näbauer M, Beuckelmann DJ, Uberfuhr P, Steinbeck G. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 93: 168-177, 1996.
29. Noble D, Cohen I. The interpretation of the T-wave of the electrocardiogram. Cardiovasc Res 12: 13-27, 1978.
30. Opthof T, Coronel R, Janse MJ. Is there a significant transmural gradient in repolarization time in the intact heart?: repolarization gradients in the intact heart. Circ Arrhythmia Electrophysiol 2: 89-96, 2009.
31. van Oosterom A, Jacquemet V. The effect of tissue geometry on the activation recovery interval of atrial myocytes. Physica D 238: 962-968, 2009.
32. Patel C, Burke JF, Patel H, Gupta P, Kowey PR, Antzelevitch C, Yan GX. Is there a significant transmural gradient in repolarization time in the intact heart?: Cellular basis of the T-wave: a century of controversy. Circ Arrhythmia Electrophysiol 2: 80-88, 2009.
33. Poelzing S, Akar FG, Baron E, Rosenbaum DS. Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall. Am J Physiol Heart Circ Physiol 286: H2001-H2009, 2004.
34. Poelzing S, Dikshteyn M, Rosenbaum DS. Transmural conduction is not a two-way street. J Cardiovasc Electrophysiol 16: 455, 2005.
35. Poelzing S. Are electrophysiologically distinct M-cells a characteristic of the wedge preparation? Heart Rhythm 6: 1035-1037, 2009.
36. Potse M, Dubé B, Richer J, Vinet A, Gulrajani RM. A Comparison of monodomain and bidomain reaction-diffusion models for action potential propagation in the human heart. IEEE Trans Biomed Eng 53: 2425-2435, 2006.
37. Qu Z. Dynamical effects of diffusive cell coupling on cardiac excitation and propagation: a simulation study. Am J Physiol Heart Circ Physiol 287: H2803-H2812, 2004.
38. Sampson KJ, Henriquez CS. Electrotonic influences on action potential duration dispersion in small hearts: a simulation study. Am J Physiol Heart Circ Physiol 289: H350-H360, 2005.
39. Shannon TR, Wang F, Puglisi J, Weber C, Bers DM. A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J 87: 3351-3371, 2004.
40. Sicouri S, Fish J, Anzelevitch C. Distribution of M-cells in the canine ventricle. J Cardiovasc Electrophysiol 5: 824-837, 1994.
41. Taccardi B, Punske BB, Sachse F, Tricoche X, Colli-Franzone P, Pavarino LF, Zabawa C. Intramural activation and repolarization sequences in canine ventricles. J Electrocardiol 38: 131-137, 2005.
42. Taggart P, Sutton PMI, Opthof T, Coronel R, Trimlett R, Pugsley W, Kallis P. Transmural repolarization in the left ventricle in humans during normoxia and ischaemia. Cardiovasc Res 50: 454-462, 2001.
43. Toyoshima H, Burgess MJ. Electrotonic interaction during canine ventricular repolarization. Circ Res 43: 348-356, 1978.
44. Vetter FJ, McCulloch AD. Three-dimensional analysis of regional cardiac function: a model of rabbit ventricular anatomy. Prog Biophys Mol Biol 69: 157-183, 1998.
45. Voss F, Opthof T, Marker J, Bauer A, Katus HA, Becker R. There is no transmural heterogeneity in an index of action potential duration in the canine left ventricle. Heart Rhythm 6: 1028-1034, 2009.
46. Walker NL, Burton FL, Kettlewell S, Smith GL, Cobbe SM. Mapping of epicardial activation in a rabbit model of chronic myocardial infarction. J Cardiovasc Electrophysiol 18: 862-868, 2007.
47. Wiegerinck RF, van Veen TA, Belterman CN, Schumacher CA, Noorman M, de Bakker JM, Coronel R. Transmural dispersion of refractoriness and conduction velocity is associated with heterogeneously reduced connexin43 in a rabbit model of heart failure. Heart Rhythm 5: 1178-1185, 2008.
48. Yan GX, Shimizu W, Antzelevitch C. Characteristics and distribution of M-cells in arterially perfused canine left ventricular wedge preparations. Circulation 98: 1921-1927, 1998.
49. Yan GX, Antzelevitch C. Cellular basis for the normal T-wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 98: 1928-1936, 1998.
50. Yan GX, Rials SJ, Wu Y, Liu T, Xu X, Marinchak RA, Kowey PR. Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization. Am J Physiol Heart Circ Physiol 281: H1968-H1975, 2001.
51. Zaritsky R, Pertsov A. Simulation of 2-D spiral wave interactions on a Pentium-based cluster. In: Proceedings of Neural, Parallel, and Scientific Computations, edited by Bekakos MP, Ladde GS, Medhin NG, Sambandham M. Atlanta, GA: Dynamic, 2002.
52. Zygmunt AC, Eddlestone GT, Thomas GP, Nesterenko VV, Antzelevitch C. Larger late sodium conductance in M-cells contributes to electrical heterogeneity in canine ventricle. Am J Physiol Heart Circ Physiol 281: H689-H697, 2001.