Regulation of intermediary metabolism by the PKCδ signalosome in mitochondria

FASEB Journal

Volumn 24, Issue 12, 2010, Pages 5033-5042

  Acin Perez, Rebeca ^a   Hoyos, Beatrice ^b   Gong, Jianli ^b   Vinogradov, Valerie ^b   Fischman, Donald A ^a   Leitges, Michael ^c   Borhan, Babak ^d   Starkov, Anatoly ^a   Manfredi, Giovanni ^a   Hammerling, Ulrich ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF OSLO   (Norway)

^d MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Cytochrome c; Energy homeostasis; Krebs cycle control; Pyruvate dehydrogenase complex; Vitamin A

Indexed keywords

CYTOCHROME C; FERRIC ION; PROTEIN KINASE C DELTA; RETINOL; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; DEPHOSPHORYLATION; DEPLETION; ENZYME ACTIVATION; ENZYME METABOLISM; GENE ACTIVITY; GENETICS; MITOCHONDRION; MOLECULE; MOUSE; MUTATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYNTHESIS;

ANIMALS; CELLS, CULTURED; CYTOCHROMES C; IMMUNOBLOTTING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MULTIPROTEIN COMPLEXES; OXIDATIVE PHOSPHORYLATION; PROTEIN KINASE C-DELTA; PROTEIN-SERINE-THREONINE KINASES; PYRUVATE DECARBOXYLASE; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; VITAMIN A;

EID: 78649734511     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-166934     Document Type: Article

References (36)

1. Majumder, P. K., Mishra, N. C., Sun, X., Bharti, A., Kharbanda, S., Saxena, S., and Kufe, D. (2001) Targeting of protein kinase C delta to mitochondria in the oxidative stress response. Cell Growth Differ. 12, 465-470 (Pubitemid 32906091)
2. Churchill, E. N., Murreil, C. L., Chen, C. H., Mochley-Rosen, D., and Szweda, L. I. (2005) Reperfusion-induced translocation of delta-PKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation. Circ. Res. 97, 78-85
3. Budas, G. R., Churchil, E. N., and Mochley-Rosen, D. (2007) Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury. Pharm. Res. 55, 523-536
4. Bright, R., and Mochley-Rosen, D. (2005) The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke 36, 2781-2790
5. Hanlon, P. R., Fu, P., Wright, G. L. Steenbergen, C., Arcasoy, M. O., and Murphy, E. (2005) Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling FASEB. J. 19, 1323-1325
6. Inagaki, K., Chen, L., Ikeno, F., Lee, F. H., Imahashi, K., Bouley, D. M., Rezaee, M., Yock, P. G., Murphy, E., and Mochly-Rosen, D. (2003) Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation 108, 2304-2307
7. Mayr, M., Metzler, B., Chung, Y. L., McGregor, E., Mayr, U., Troy, H., Hu, Y., Leitges, M., Pachinger, O., Griffiths, J. R., Dunn, M. J., and Q, X. (2004) Ischemic preconditioning exaggerates cardiac damage in PKC-d null mice. Am. J. Physiol. Heart Circ. Physiol. 287, H946-H956
8. Chiu, H. J., Fischman, D. A., and Hammerling, U. (2008) Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation. FASEB. J. 22, 3878-3887
9. Acin-Perez, R., Hoyos, B., Zhao, F., Vinogradov, V., Fischman, D. A., Harris, R. A., Leitges, M., Wongsiriroj, N., Blaner, W. S., Manfredi, G., and Hammerling, U. (2010) Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. FASEB. J. 24, 627-636
10. Hoyos, B., Imam, A., Korichneva, I., Levi, E., Chua, R., and Hammerling, U. (2002) Activation of c-Raf kinase by ultraviolet light. J. Biol. Chem. 277, 23949-23947
11. Hoyos, B., Jiang, S., and Hammerling, U. (2005) Location and functional significance of retinol binding sites on the serine/threonine kinase, cRaf. J. Biol. Chem. 280, 6872-6878
12. Imam, A., Hoyos, B., Swenson, C., Chua, R., Levi, E., Viriya, E., and Hammerling, U. (2000) Retinoids as ligands and coactivators of protein kinase C alpha. [Online] FASEB. J. doi: 10.1096/fjf.1000-1329fje
13. Korichneva, I., Hoyos, B., Chua, R., Levi, E., and Hammerling, U. (2002) Zinc-release from protein kinase C as the common event during activation by lipid second messenger or reactive oxygen. J. Biol. Chem. 277, 44327-44331
14. Knapp, L. T., and Klann, E. (2000) Superoxide-induced stimulation of protein kinase C via thiol modification and modulation of zinc content. J. Biol. Chem. 275, 24136-24145
15. Nishizuka, Y. (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614
16. Nishizuka, Y. (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB. J. 9, 484-496
17. Zhang, G., Kazanietz, M. G., Blumberg, P. M., and Hurley, J. H. (1995) Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell 81, 917-924
18. Kikkawa, U., Matsuzaki, H., and Yamamoto, T. (2002) Protein kinase Cδ (PKCδ): activation mechanisms and functions. J. Biochem. 132, 831-839
19. Hurley, J. H., and Grobler, J. A. (1997) Protein kinase C and phospholipase C: bilayer interactions and regulation. Curr. Opin. Struct. Biol. 7, 557-565
20. 2. Proc. Natl. Acad. SAci. 94, 11233-11237
21. Gopalakrishna, R., Gundimeda, U., Schiffman, J. E., and McNeill, T. H. (2008) A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J. Biol. Chem. 283, 14430-14444
22. Nathan, C. (2003) Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. J. Clin. Invest. 111, 769-778
23. Arany, I., Faisal, A., Clark, J. S., Vera, T., Baliga, R., and Nagamine, Y. (2010) p66SHC-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injury. Am. J. Physiol. Renal. Physiol. 298, 1214-1221
24. Giorgio, M., Migliaccio, E., Orsini, F., Paolucci, D., Moroni, M., Contursi, C., Pellicia, G., Luzi, L., Minucci, S., Marcaccio, M., Pinton, P., Rizzuto, R., Bernardi, P., Paolucci, F., and Pelicci, P. G. (2005) Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122, 221-233
25. Vogel, S., Piantedosi, R., O'Byrne, S. M., Kako, Y., Quadro, L., Gottesman, M. E., Goldberg, I. J., and Blaner, W. S. (2002) Retinol-binding protein-deficient mice: biochemical basis for impaired vision. Biochemistry 41, 15360-15368
26. 2-stimulated cells. J. Biol. Chem. 143, 31-38
27. Tan, Q., Lou, J., Borhan, B., Karnaukova, E., N., B., and Nakanishi, K. (1997) Absolute sense of twist of the C12-C13 bond of the retinal chromophore in bovine rhodopsin based on exciton-coupled CD spectra of 11,12-dihydroretinal. Angew. Chem. Int. Ed. 19, 2089-2093
28. Fernandez-Vizarra, E., Lopez-Perez, M. J., and Enriquez, J. A. (2002) Isolation of biogenetically competent mitochondria from mammalian tissues and cultured cells. Methods 26, 292-297
29. Hofhaus, G., Johns, D. R., Hurko, O., Attardi, G., and Chomyn, A. (1996) Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber's hereditary optic neuropathy. J. Biol. Chem. 271, 13155-13161
30. Vives-Bauza, C., Yang, L., and Manfredi, G. (2007) Assay of mitochondrial ATP synthesis in animal cells and tissues. Methods Cell Biol. 80, 155-171
31. Acin-Perez, R., Salazar, E., Kamenetsky, M., Buck, J., Levin, L. R., and Manfredi, G. (2009) Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab. 9, 265-276
32. Gray, M. O., Zhou, H. Z., Schafhalter-Zoppoth, I., Zhu, P., Mochly-Rosen, D., and Messing, R. O. (2004) Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon. J. Biol. Chem. 279, 3596-3604
33. Patel, M., and Korotchinka, L. (2006) Regulation of the pyruvate dehydrogenase complex. Biochem. Soc. Trans. 34, 217-222
34. D'Aurelio, M., Pallotti, F., Barrientos, A., Gajewski, C. D., Kwong, J. Q., Bruno, C., Beal, M. F., and Manfredi, G. (2001) In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I. J. Biol. Chem. 276, 46925-46932
35. Jakob, U., Muse, W., Eser, M., and Bardwell, J. C. (1999) Chaperone activity with a redox switch. Cell 96, 341-352
36. Graumann, J., Lilie., H., Tang, X., Tucker, K. A., Hoffmann, J. H., Vijayalakshmi, J., Saper, M., Bardwell, J. C. A., and Jakob, U. (2001) Activation of the redox-regulated molecular chaperone Hsp33A two-step mechanism. Structure 9, 377-387