Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

Biochemical Journal

Volumn 432, Issue 1, 2010, Pages 207-216

  Bird, Rebecca J ^a   Baillie, George S ^a   Yarwood, Stephen J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

cAMP; Intracellular targeting; Phosphodiesterase (PDE); Protein kinase C (PKC); Receptor for activated c kinase 1 (RACK1)

Indexed keywords

CAMP; INTRACELLULAR TARGETING; PHOSPHODIESTERASE (PDE); PROTEIN KINASE C (PKC); RECEPTOR FOR ACTIVATED C-KINASE 1 (RACK1);

CHEMICAL ACTIVATION; CROSSTALK; ENZYME ACTIVITY; ENZYMES; PHOSPHORYLATION;

FETAL MONITORING;

3 [1 (3 AMINOPROPYL) 3 INDOLYL] 4 (1 METHYL 3 INDOLYL) 1H PYRROLE 2,5 DIONE; CYCLIC AMP; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 4D5; PROTEIN KINASE C; RECEPTOR FOR ACTIVATED C KINASE 1; RECOMBINANT ENZYME; ROLIPRAM; UNCLASSIFIED DRUG;

ARTICLE; CELL FRACTIONATION; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG SENSITIZATION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME REGULATION; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNOPRECIPITATION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BINDING SITES; BLOTTING, WESTERN; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; ENZYME ACTIVATION; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; HYDROLYSIS; INTRACELLULAR SPACE; ISOPROTERENOL; KINETICS; MUTATION; NEOPLASM PROTEINS; PHOSPHODIESTERASE 4 INHIBITORS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN TRANSPORT; RECEPTORS, CELL SURFACE; ROLIPRAM; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

EID: 78649730777     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101010     Document Type: Article

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