Formulations of biodegradable Nanogel carriers with 5′-triphosphates of nucleoside analogs that display a reduced cytotoxicity and enhanced drug activity

Journal of Controlled Release

Volumn 121, Issue 1-2, 2007, Pages 19-27

  Kohli, Ekta ^a   Han, Huai Yun ^a   Zeman, Arin D ^a   Vinogradov, Serguei V ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Delivery vehicle; Influenza A virus; Mitochondrial toxicity; Nanogel polymer network; Nucleoside analogs 5 triphosphates

Indexed keywords

BIODEGRADABILITY; CROSSLINKING; CYTOTOXICITY; NANOPARTICLES; VIRUSES;

DELIVERY VEHICLES; INFLUENZA A VIRUS; MITOCHONDRIAL TOXICITY; NANOGEL POLYMER NETWORKS; NUCLEOSIDE ANALOGS TRIPHOSPHATES; POLYETHYLENIMINE (PEI);

GELS;

ADENOSINE TRIPHOSPHATE; ANTIVIRUS AGENT; DEAMINASE; NANOPARTICLE; PHOSPHATE; POLOXAMER; POLYETHYLENEIMINE; POLYMER; RIBAVIRIN; ZIDOVUDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIODEGRADABILITY; CELL DEATH; CONTROLLED STUDY; CROSS LINKING; CYTOSOL; CYTOTOXICITY; DISSOCIATION; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ENCAPSULATION; GEL; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; MITOCHONDRION; NANOTECHNOLOGY; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REDUCTION; SYNTHESIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIVIRAL AGENTS; BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; FEMALE; FLUORESCENT DYES; FORMAZANS; HUMANS; INFLUENZA A VIRUS; INHIBITORY CONCENTRATION 50; KIDNEY; L-LACTATE DEHYDROGENASE; LUMINESCENT MEASUREMENTS; MEMBRANE POTENTIALS; MITOCHONDRIA; NANOTECHNOLOGY; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RHODAMINES; RIBAVIRIN; SENSITIVITY AND SPECIFICITY; TETRAZOLIUM SALTS; THYMINE NUCLEOTIDES; ZIDOVUDINE;

EID: 34547234696     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.04.007     Document Type: Article

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