Differential effects of adenosine A 2aand A 2b receptors on cardiac contractility

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 6, 2010, Pages

  Chandrasekera, P Charukeshi ^a   McIntosh, Victoria J ^a   Cao, Frank X ^a   Lasley, Robert D ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

A 2a adenosine receptor; A 2b adenosine receptor; Cardiac contractility; Knockout mice

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 CHLORO 6 N CYCLOPENTYLADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ISOPRENALINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BAY REGION BINDING SITE; CONTROLLED STUDY; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; INOTROPISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ADENOSINE A2 RECEPTOR AGONISTS; ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIAC PACING, ARTIFICIAL; CORONARY CIRCULATION; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCARDIUM; PERFUSION; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A2B; RECEPTOR, ADENOSINE A3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 78649721502     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00511.2010     Document Type: Article

References (34)

1. 2B adenosine receptor from mouse, rabbit, and dog. J Pharmacol Exp Ther 329: 2-13, 2009.
2. 2A adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther 284: 1066-1073, 1998.
3. 2A receptor heteromers in human brain caudate nucleus. J Neurochem 114: 972-980, 2010.
4. 2b receptors in cardiac fibroblasts. Am J Physiol Heart Circ Physiol 287: H2478-H2486, 2004.
5. Ciruela F, Ferre S, Casado V, Cortes A, Cunha RA, Lluis C, Franco R. Heterodimeric adenosine receptors: a device to regulate neurotransmitter release. Cell Mol Life Sci 63: 2427-2431, 2006.
6. 2 receptor function in rat ventricular myocytes. Cardiovasc Res 34: 337-347, 1997.
7. Dobson JG Jr, Ordway RW, Fenton RA. Endogenous adenosine inhibits catecholamine contractile responses in normoxic hearts. Am J Physiol Heart Circ Physiol 251: H455-H462, 1986.
8. 2A and β-adrenergic calcium transient and contractile responses in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 295: H2364-H2372, 2008.
9. Drury AN, Szent-Gyorgyi A. The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol 68: 213-237, 1929.
10. 2B adenosine receptors. Circulation 115: 1581-1590, 2007.
11. 2B receptors induces interleukin-6 secretion in cardiac fibroblasts via the PKC-δ-P38 signalling pathway. Br J Pharmacol 159: 1598-1607, 2010.
12. 2+ transients of isoproterenol-stimulated rat ventricular myocytes. Am J Physiol Cell Physiol 261: C1107-C1114, 1991.
13. 2a receptor activation fails to alter cAMP or contractility: role of receptor localization. Am J Physiol Heart Circ Physiol 282: H1035-H1040, 2002.
14. 2a agonist CGS-21680 in infarcted and stunned porcine myocardium. Am J Physiol Heart Circ Physiol 280: H1660-H1666, 2001.
15. 2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium. Am J Physiol Heart Circ Physiol 292: H426-H431, 2007.
16. 1 receptor mechanism. Am J Physiol Heart Circ Physiol 263: H1460-H1465, 1992.
17. 2b receptors in cultured fetal chick heart cells. High- and low-affinity coupling to stimulation of myocyte contractility and cAMP accumulation. Circ Res 76: 242-251, 1995.
18. 1 adenosine receptors of intact rat ventricular myocytes. Circ Res 63: 613-620, 1988.
19. 2a-receptor activation increases contractility in isolated perfused hearts. Am J Physiol Heart Circ Physiol 279: H1472-H1481, 2000.
20. 2B receptors. Am J Physiol Heart Circ Physiol 282: H437-H444, 2002.
21. 1 adenosine receptors on postischemic cardiac function and expression of adenosine receptor subtypes. Am J Physiol Heart Circ Physiol 291: H1875-H1882, 2006.
22. Mustafa SJ, Morrison RR, Teng B, Pelleg A. Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology. Handb Exp Pharmacol 161-188, 2009.
23. 2a receptor activation in rat heart. Am J Physiol Heart Circ Physiol 276: H341-H349, 1999.
24. O'Connell TD, Ni YG, Lin K, Han H, Yan Z. Isolation and culture of adult mouse cardiac myocytes for signaling studies. Alliance Cell Signal 1: 1-9, 2003.
25. 2B receptors in cultured human and porcine coronary artery endothelial cells. Am J Physiol Heart Circ Physiol 279: H650-H656, 2000.
26. Peart JN, Headrick JP. Adenosinergic cardioprotection: multiple receptors, multiple pathways. Pharmacol Ther 114: 208-221, 2007.
27. 1 adenosine receptor. Circ Res 96: 982-990, 2005.
28. 2A adenosine receptor knockout mouse coronary artery. J Mol Cell Cardiol 44: 905-914, 2008.
29. 2A receptor regulation of protein phosphatase 2A in the murine heart. J Cell Physiol 216: 83-90, 2008.
30. 2A receptors in isolated murine hearts. Am J Physiol Heart Circ Physiol 290: H348-H356, 2006.
31. Willems L, Headrick JP. Contractile effects of adenosine, coronary flow and perfusion pressure in murine myocardium. Pflügers Arch 453: 433-441, 2007.
32. 2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol 47: 684-690, 2009.
33. 2a receptor in adult rat ventricular myocyte. Am J Physiol Heart Circ Physiol 270: H1655-H1661, 1996.
34. Yan L, Burbiel JC, Maass A, Müller CE. Adenosine receptor agonists: from basic medicinal chemistry to clinical development. Expert Opin Emerg Drugs 8: 537-76, 2003.