Effect of diclofenac on cyclooxygenase-2 levels and early breaking strength of experimental colonic anastomoses and skin incisions

European Surgical Research

Volumn 46, Issue 1, 2011, Pages 26-31

  Klein, M ^a   Krarup, P M ^a   Burcharth, J ^a   Agren M S ^a   Gogenur I ^a   Jorgensen, L N ^a   Rosenberg, J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Anastomoses, experimental; Anastomotic leakage; Breaking strength; Colorectal surgery; Cyclooxygenase 2; Nonsteroidal anti inflammatory drugs

Indexed keywords

CYCLOOXYGENASE 2; DICLOFENAC; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; COLON ANASTOMOSIS; COLON RESECTION; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; NONHUMAN; OPERATION DURATION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT; SKIN INCISION; SURGICAL WOUND; TENSILE STRENGTH;

ANASTOMOSIS, SURGICAL; ANASTOMOTIC LEAK; ANIMALS; BIOMECHANICS; COLECTOMY; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; MALE; PROSPECTIVE STUDIES; RANDOM ALLOCATION; RATS; RATS, WISTAR; SKIN; WOUND HEALING;

EID: 78649696798     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000321706     Document Type: Article

References (30)

1. Holte K, Andersen J, Jakobsen DH, Kehlet H: Cyclo-oxygenase 2 inhibitors and the risk of anastomotic leakage after fast-track colonic surgery. Br J Surg 2009; 96: 650-654.
2. Klein M, Andersen LP, Harvald T, Rosenberg J, Gogenur I: Increased risk of anastomotic leakage with diclofenac treatment after laparoscopic colorectal surgery. Dig Surg 2009; 26: 27-30.
3. Rosenberg J, Harvald T: Severe complications with diclofenac after colonic resection. Dis Colon Rectum 2007; 50: 685.
4. de Hingh IH, de Man BM, Lomme RM, van Goor H, Hendriks T: Colonic anastomotic strength and matrix metalloproteinase activity in an experimental model of bacterial peritonitis. Br J Surg 2003; 90: 981-988.
5. Binnebosel M, Junge K, Kaemmer DA, Krones CJ, Titkova S, Anurov M, Schumpelick V, Klinge U: Intraperitoneally applied gentamicin increases collagen content and mechanical stability of colon anastomosis in rats. Int J Colorectal Dis 2009; 24: 433-440.
6. Syk I, Mirastschijski U, Jeppsson BW, Agren MS: Experimental colonic obstruction increases collagen degradation by matrix metalloproteinases in the bowel wall. Dis Colon Rectum 2003; 46: 1251-1259.
7. Cahill RA, Sheehan KM, Scanlon RW, Murray FE, Kay EW, Redmond HP: Effects of a selective cyclo-oxygenase 2 inhibitor on colonic anastomotic and skin wound integrity. Br J Surg 2004; 91: 1613-1618.
8. de Sousa JB, Soares EG, Aprilli F: Effects of diclofenac sodium on intestinal anastomotic healing. Experimental study on the small intestine of rabbits. Dis Colon Rectum 1991; 34: 613-617.
9. Inan A, Koca C, Sen M: Effects of diclofenac sodium on bursting pressures of anastomoses and hydroxyproline contents of perianastomotic tissues in a laboratory study. Int J Surg 2006; 4: 222-227.
10. Mastboom WJ, Hendriks T, van Elteren P, de Boer HH: The influence of NSAIDs on experimental intestinal anastomoses. Dis Colon Rectum 1991; 34: 236-243.
11. Månsson P, Zhang XW, Jeppsson B, Thorlacius H: Anastomotic healing in the rat colon: comparison between a radiological method, breaking strength and bursting pressure. Int J Colorectal Dis 2002; 17: 420-425.
12. Agren MS, Andersen L, Heegaard AM, Jorgensen LN: Effect of parenteral zinc sulfate on colon anastomosis repair in the rat. Int J Colorectal Dis 2008; 23: 857-861.
13. Patrono C, Patrignani P, Garcia Rodriguez LA: Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs. J Clin Invest 2001; 108: 7-13.
14. Freire CN, Hussni CA, Bonetti YW, Swain MS, Sequeira JL, Rodrigues AC, Mattar L, Crocci AJ: Effect of diclofenac sodium on the healing process of end-to-end anastomosis in carotid arteries of rabbits. Histopathological and biomechanical studies. Int Angiol 2003; 22: 431-437.
15. Menasse R, Hedwall PR, Kraetz J, Pericin C, Riesterer L, Sallmann A, Ziel R, Jaques R: Pharmacological properties of diclofenac sodium and its metabolites. Scand J Rheumatol Suppl 1978; 22: 5-16.
16. Willis JV, Kendall MJ, Flinn RM, Thornhill DP, Welling PG: The pharmacokinetics of diclofenac sodium following intravenous and oral administration. Eur J Clin Pharmacol 1979; 16: 405-410.
17. de Hingh IH, van Goor H, de Man BM, Lomme RM, Bleichrodt RP, Hendriks T: Selective cyclo-oxygenase 2 inhibition affects ileal but not colonic anastomotic healing in the early postoperative period. Br J Surg 2006; 93: 489-497.
18. Nussmeier NA, Whelton AA, Brown MT, Langford RM, Hoeft A, Parlow JL, Boyce SW, Verburg KM: Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med 2005; 352: 1081-1091.
19. McGettigan P, Henry D: Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA 2006; 296: 1633-1644.
20. Krotz F, Struthmann L: A review on the risk of myocardial infarction associated with the NSAID diclofenac. Cardiovasc Hematol Disord Drug Targets 2010; 10: 53-65.
21. Mitchell JA, Warner TD: Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy. Br J Pharmacol 1999; 128: 1121-1132.
22. Khan AA, Iadarola M, Yang HY, Dionne RA: Expression of COX-1 and COX-2 in a clinical model of acute inflammation. J Pain 2007; 8: 349-354.
23. Futagami A, Ishizaki M, Fukuda Y, Kawana S, Yamanaka N: Wound healing involves induction of cyclooxygenase-2 expression in rat skin. Lab Invest 2002; 82: 1503-1513.
24. Blomme EA, Chinn KS, Hardy MM, Casler JJ, Kim SH, Opsahl AC, Hall WA, Trajkovic D, Khan KN, Tripp CS: Selective cyclooxygenase- 2 inhibition does not affect the healing of cutaneous full-thickness incisional wounds in SKH-1 mice. Br J Dermatol 2003; 148: 211-223.
25. Neuss H, Raue W, Muller V, Weichert W, Schwenk W, Mall JW: Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model - a randomized, blinded, placebocontrolled trial. Int J Colorectal Dis 2009; 24: 551-557.
26. de Hingh IH, Siemonsma MA, de Man BM, Lomme RM, Hendriks T: The matrix metalloproteinase inhibitor BB-94 improves the strength of intestinal anastomoses in the rat. Int J Colorectal Dis 2002; 17: 348-354.
27. Hendriks T, Mastboom WJ: Healing of experimental intestinal anastomoses. Parameters for repair. Dis Colon Rectum 1990; 33: 891-901.
28. Ikeuchi D, Onodera H, Aung T, Kan S, Kawamoto K, Imamura M, Maetani S: Correlation of tensile strength with bursting pressure in the evaluation of intestinal anastomosis. Dig Surg 1999; 16: 478-485.
29. Kingham TP, Pachter HL: Colonic anastomotic leak: risk factors, diagnosis, and treatment. J Am Coll Surg 2009; 208: 269-278.
30. Witte MB, Barbul A: Repair of full-thickness bowel injury. Crit Care Med 2003; 31:S538-S546.