AT1 receptor and NAD(P)H oxidase mediate angiotensin II-stimulated antioxidant enzymes and mitogen-activated protein kinase activity in the rat hypothalamus

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 11, Issue 4, 2010, Pages 234-242

  Silva, José ^a   Pastorello, Mariella ^a   Arzola, Jorge ^a   Zavala, Lida E ^a   De Jesús, Sara ^a   Varela, Maider ^a   Matos, María Gabriela ^a   Del Rosario Garrido, María ^a   Israel, Anita ^a  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

angiotensin II; apocynin; catalase; chelerythrine; glutathione peroxidase; oxidative stress; PD 123319; superoxide dismutase

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANTIOXIDANT; APOCYNIN; CATALASE; CHELERYTHRINE; GLUTATHIONE PEROXIDASE; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE; ACETOPHENONE DERIVATIVE; ANGIOTENSIN II; BENZOPHENANTHRIDINE DERIVATIVE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; SODIUM; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DECAPITATION; DIURESIS; ENZYME ACTIVITY; FLAME PHOTOMETRY; HYPOTHALAMUS; MALE; MICRODISSECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; SODIUM URINE LEVEL; SPECTROPHOTOMETRY; STEREOMICROSCOPY; WESTERN BLOTTING; ANIMAL; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; SPRAGUE DAWLEY RAT; URINE;

ACETOPHENONES; ANGIOTENSIN II; ANIMALS; ANTIOXIDANTS; BENZOPHENANTHRIDINES; CATALASE; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTATHIONE PEROXIDASE; HYPOTHALAMUS; IMIDAZOLES; INJECTIONS, INTRAVENTRICULAR; LOSARTAN; MALE; NADPH OXIDASE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; SODIUM; SUPEROXIDE DISMUTASE; WATER;

EID: 78649677383     PISSN: 14703203     EISSN: None     Source Type: Journal    
DOI: 10.1177/1470320310376987     Document Type: Article

References (45)

1. Saavedra JM, Benicky J. and Zhou J. Angiotensin II: multitasking in the brain. J Hypertens Suppl 2006 ; 24: S131 - S137.
2. Weisinger RS, Blair-West JR, Burns P., Denton DA and Tarjan E. Role of brain angiotensin in thirst and sodium appetite of rats. Peptides. 1997 ; 18: 977-984.
3. Sakai RR, He PF, Yang XD, Ma LY, Guo YF, Reilly JJ et al. Intracerebroventricular administration of AT1 receptor antisense oligonucleotides inhibits the behavioral actions of angiotensin II. J Neurochem. 1994 ; 62: 2053-2056.
4. Griendling KK, Minieri CA, Ollerenshaw JD and Alexander RW Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994 ; 74: 1141-1148.
5. Griendling KK, Sorescu D. and Ushio-Fukai M. NAD(P) H oxidase: Role in cardiovascular biology and disease. Circ Res 2000 b; 86: 494-501.
6. Atlante A., Calissano P., Bobba A., Giannattasio S., Marra E. and Passarella S. Glutamate neurotoxicity, oxidative stress and mitochondria. FEBS Lett 2001 ; 497: 1-5.
7. Pou S., Pou WS, Bredt DS, Snyder SH and Rosen GM Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem 1992 ; 267: 24173-24176.
8. Wang G., Anrather J., Huang J., Speth RC, Pickel VM and Iadecola C. NAD(P)H oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. J Neurosci 2004 ; 24: 5516-24.
9. Landmesser U., Cai H., Dikalov S., McCann L., Hwang J., Jo H. et al. Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension 2002 ; 40: 511-515.
10. Babior BM NADPH oxidase: An update. Blood 1999 ; 93: 1464-6.
11. Richards EM, Raizada MK, Gelband CH and Sumners C. Angiotensin II type 1 receptor-modulated signaling pathways in neurons. Mol Neurobiol 1999 ; 19: 25-41.
12. Sumners C., Fleegal MA and Zhu MY Angiotensin AT-1 receptor signalling pathways in neurons. Clin Exp Pharmacol Physiol 2002 ; 29: 483-490.
13. Chan SH, Hsu KS, Huang CC, Wang LL, Ou CC and Chan JY NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla. Circ Res 2005 ; 97: 772-780.
14. Erdös B., Broxson CS, King MA, Scarpace PJ and Tümer N. Acute pressor effect of central angiotensin II is mediated by NAD(P)H-oxidase- dependent production of superoxide in the hypothalamic cardiovascular regulatory nuclei. J Hypertens 2006 ; 24: 109-116.
15. Sun C., Sellers KW, Sumners C. and Raizada MK NAD(P) H oxidase inhibition attenuates neuronal chronotrophic actions of angiotensin II. Circ Res 2005 ; 96: 659-666.
16. Zimmerman MC, Sharma RV and Davisson RL Superoxide mediates angiotensin II-induced influx of extracellular calcium in neural cells. Hypertension 2005 ; 45: 717-723.
17. Gelband CH, Sumners C., Lu D. and Raizada MK Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling. Regul Pept 1997 ; 72: 139-145.
18. Griendling KK and Ushio-Fukai M. Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept 2000 a; 91: 21-27.
19. Yoshizumi M., Tsuchiya K. and Tamaki T. Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease. J Med Invest 2001 ; 48: 11-24.
20. Yang H. and Raizada MK MAP kinase-independent signaling in angiotensin II regulation of neuromodulation in SHR neurons. Hypertension 1998 ; 32: 473-481. (Pubitemid 28429136)
21. Lindenau J., Noack H., Possel H., Asayarna K. and Wolf G. Cellular distribution of superoxide dismutases in the rat CNS. Glia 2000 ; 29: 25-34.
22. Aebi H. Catalase. In: Packer L (ed) Methods in Enzymology. Orlando: Academic Press, 1984, pp. 121-126.
23. Oberley LW and Spitz DR Assay of superoxide dismutase activity in tumor tissue. Meth Enzymol 1984 ; 105: 457-464.
24. Flohé L. and Günzler WA Assays of glutathione peroxidase. Methods in Enzymology 1984 ; 105: 114-121.
25. Lowry OH, Rosebrough NJ, Farr Al and Randall RJ Protein measurement with the Folin phenol reagent. J Biol Chem 1951 ; 193: 265-275.
26. Deng WX, Henati A. and Tanier JA Amyotrophic lateral sclerosis and structural defects in Cu, Zn superoxide dismutase. Science 2005 ; 261: 1047-1051.
27. Smith MA, Richey-Harris PL, Sayre LM, Beckman JS and Perry G. Widespread peroxynitrite-mediated damage in Alzheirner's disease. J Neurosci 1997 ; 17: 2653-2657.
28. Zimmerman MC, Lazartigues E., Lang JA, Sinnayah P., Ahmad IM, Spitz DR et al. Superoxide mediates the actions of angiotensin II in the central nervous system. Cir Res 2002 ; 91: 1038-1045.
29. Mayorov DN, Head GA and De Matteo R. Tempol attenuates excitatory actions of angiotensin II in the rostral ventrolateral medulla during emotional stress. Hypertension 2004 ; 44: 101-106
30. Sohn HY, Raff U., Hoffman A., Gloe T., Heermeier K., Galle J. et al. Differential role of angiotensin II receptor subtypes on endothelial superoxide formation. British J Pharmacol 2000 ; 131: 667-672.
31. Lassegue B. and Clempus RE Vascular NAD(P)H oxidase: specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol 2003 ; 285: R277 - R297.
32. Sun C., Sumners C. and Raizada MK Chronotropic action of angiotensin II in neurons via protein kinase C and CaMKII. Hypertension 2002 ; 39: 562-566.
33. Wang D., Gelband CH, Sumners C. and Posner P. Mechanisms underlying the chronotropic effect of angiotensin II on cultured neurons from rat hypothalamus and brain stem. J Neurophysiol 1997 a; 78: 1013-1020. (Pubitemid 27353562)
34. Wang D., Sumners C., Posner P. and Gelband CH A-type K+ current in neurons cultured from neonatal rat hypothalamus and brain stem: modulation by angiotensin II. J Neurophysiol 1997 b; 78: 1021-1029. (Pubitemid 27353563)
35. Sumners C., Zhu M., Gelband CH and Posner P. Angiotensin II type 1 receptor modulation of neuronal K+ and Ca2+ currents: intracellular mechanisms. Am J Physiol Cell Physiol 1996 ; 271: C154 - C163.
36. Fleegal M.A. and Sumners C. Drinking behavior elicited by central injection of angiotensin II: roles for protein kinase C and Ca+2/calmodulin dependent protein kinase II. Am J Physiol Regul Integr Comp Physiol 2003 ; 285: 632-640.
37. Israel A., Arzola J., De Jesús S. and Varela M. Role of oxidative stress in the natriuresis induced by central administration of angiotensin II. J Renin Angiotensin Aldosterone Syst 2009 ; 10: 9-14.
38. Zhu M., Craig GH, Posner P. and Sumners C. Angiotensin II decreases neuronal delayed rectifier potassium current: Role of calcium/calmodulin- dependent protein kinase II. J Neurophysiol 1999 ; 82: 1560-1568.
39. Ushio-Fukai M., Alexander RW, Akers M. and Griendling KK p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy. J Biol Chem 1998 ; 273: 15022-15029.
40. Touzy RM, He G., Mabrouk ME, Diep Q., Mardigyan V. and Schiffrin EL Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats. J Hypertens 2001 ; 19: 553-559.
41. Touzy RM, Cruzado M., Tabet F., Yo G., Salomon S. and Schiffrin EL Redox-dependent AMP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation. Can J Physiol Pharmacol 2003 ; 81: 159-167.
42. Zhang GX, Kimura S., Nishiyama A., Shokoji T., Rahman M. and Abe Y. ROS during the acute phase of Ang II hypertension participates in cardiovascular MAPK activation but not vasoconstriction. Hypertension 2004 ; 43: 117-124.
43. Wenzel S., Taimor G., Piper HM and Schluter KD Redox-sensitive intermediates mediate angiotensin II-induced p38 MAP kinase activation, AP-1 binding activity, and TGF-ß expression in adult ventricular cardiomyocytes. FASEB J 2001 ; 15: 2291-2299.
44. Gerald D.F., Eguchi S., Yamakawa T., Tanaka S., Inagami T. and Motley ED Involvement of reactive oxygen species in the activation of tyrosine kinase and extracellular signal-regulated kinase by angiotensin II. Endocrinology 2000 ; 141: 3120-3126.
45. Li JM, Wheatcroft S., Fan LM, Kearney MT and Shah AM Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation. Circulation 2004 ; 109: 1307-1313.