Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining

FEBS Letters

Volumn 584, Issue 23, 2010, Pages 4735-4739

  Velma, Venkatramreddy ^a   Carrero, Zunamys I ^a   Cosman, Angela M ^a   Hebert, Michael D ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Coilin; Ku70; Ku80; NHEJ

Indexed keywords

BINDING PROTEIN; COILIN; KU ANTIGEN; KU80 PROTEIN; NUCLEAR PROTEIN; SMB' PROTEIN; SURVIVAL MOTOR NEURON PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; BINDING SITE; COILED BODY; CONTROLLED STUDY; DNA REPAIR; HUMAN; HUMAN CELL; NONHOMOLOGOUS DNA END JOINING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

BINDING, COMPETITIVE; DNA HELICASES; DNA REPAIR; HELA CELLS; HUMANS; NUCLEAR PROTEINS; RECOMBINATION, GENETIC; SNRNP CORE PROTEINS; SURVIVAL OF MOTOR NEURON 1 PROTEIN;

EID: 78649658701     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.11.004     Document Type: Article

References (26)

1. Cioce M., Lamond A.I. Cajal bodies: a long history of discovery. Annu. Rev. Cell Dev. Biol. 2005, 21:105-131.
2. Matera A.G., Izaguire-Sierra M., Praveen K., Rajendra T.K. Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?. Dev. Cell 2009, 17:639-647.
3. Morris G.E. The Cajal body. Biochim. Biophys. Acta 2008, 1783:2108-2115.
4. Hebert M.D. Phosphorylation and the Cajal body: modification in search of function. Arch. Biochem. Biophys. 2010, 496:69-76.
5. Barcaroli D., et al. FLASH is required for histone transcription and S-phase progression. Proc. Natl. Acad. Sci. USA 2006, 103:14808-14812.
6. Tucker K.E., et al. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. J. Cell Biol. 2001, 154:293-307.
7. Walker M.P., Tian L., Matera A.G. Reduced viability, fertility and fecundity in mice lacking the cajal body marker protein, coilin. PLoS One 2009, 4:e6171.
8. Strzelecka M., Trowitzsch S., Weber G., Luhrmann R., Oates A.C., Neugebauer K.M. Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nat. Struct. Mol. Biol. 2010, 17:403-409.
9. Hebert M.D., Szymczyk P.W., Shpargel K.B., Matera A.G. Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein. Genes Dev. 2001, 15:2720-2729.
10. Hebert M.D., Shpargel K.B., Ospina J.K., Tucker K.E., Matera A.G. Coilin methylation regulates nuclear body formation. Dev. Cell 2002, 3:329-337.
11. Xu H., Pillai R.S., Azzouz T.N., Shpargel K.B., Kambach C., Hebert M.D., Schumperli D., Matera A.G. The C-terminal domain of coilin interacts with Sm proteins and U snRNPs. Chromosoma 2005, 114:155-166.
12. Carmo-Fonseca M., Ferreira J., Lamond A.I. Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis - evidence that the coiled body is a kinetic nuclear structure. J. Cell Biol. 1993, 120:841-852.
13. Hebert M.D., Matera A.G. Self-association of coilin reveals a common theme in nuclear body localization. Mol. Biol. Cell 2000, 11:4159-4171.
14. Hearst S.M., et al. Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines. J. Cell Sci. 2009, 122:1872-1881.
15. Toyota C.G., Davis M.D., Cosman A.M., Hebert M.D. Coilin phosphorylation mediates interaction with SMN and SmB'. Chromosoma 2010, 119:205-215.
16. Lam Y.W., Lyon C.E., Lamond A.I. Large-scale isolation of Cajal bodies from HeLa cells. Mol. Biol. Cell 2002, 13:2461-2473.
17. Sun J., Xu H., Subramony S.H., Hebert M.D. Interactions between Coilin and PIASy partially link Cajal bodies to PML bodies. J. Cell Sci. 2005, 118:4995-5003.
18. Pastwa E., Somiari R.I., Malinowski M., Somiari S.B., Winters T.A. In vitro non-homologous DNA end joining assays - the 20th anniversary. Int. J. Biochem. Cell Biol. 2009, 41:1254-1260.
19. Wang H., Perrault A.R., Takeda Y., Qin W., Iliakis G. Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res. 2003, 31:5377-5388.
20. Downs J.A., Jackson S.P. A means to a DNA end: the many roles of Ku. Nat. Rev. Mol. Cell Biol. 2004, 5:367-378.
21. Mimori T., Akizuki M., Yamagata H., Inada S., Yoshida S., Homma M. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap. J. Clin. Invest. 1981, 68:611-620.
22. Lieber M.R., Ma Y., Pannicke U., Schwarz K. The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst) 2004, 3:817-826.
23. Dynan W.S., Yoo S. Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Res. 1998, 26:1551-1559.
24. Morency E., Sabra M., Catez F., Texier P., Lomonte P. A novel cell response triggered by interphase centromere structural instability. J. Cell Biol. 2007, 177:757-768.
25. Cioce M., Boulon S., Matera A.G., Lamond A.I. UV-induced fragmentation of Cajal bodies. J. Cell Biol. 2006, 175:401-413.
26. Wang Y., Ghosh G., Hendrickson E.A. Ku86 represses lethal telomere deletion events in human somatic cells. Proc. Natl. Acad. Sci. USA 2009, 106:12430-12435.