The cause of systemic lupus erythematosus: Implication of 'self-organized criticality theory of autoimmunity' on the pathogenesis of systemic lupus erythematosus

International Journal of Clinical Rheumatology

Volumn 5, Issue 6, 2010, Pages 619-626

  Shiozawa, Shunichi ^a,b,c  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KOBE UNIVERSITY   (Japan)

^c Global Center of Excellence (GCOE)   (Japan)

Author keywords

antigen cross presentation; antigen presentation; autoimmune disease; autoimmunity; self organized criticality; SLE; systemic lupus erythematosus

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; OVALBUMIN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

AUTOIMMUNITY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CROSS PRESENTATION; CYTOTOXIC T LYMPHOCYTE; HUMAN; IMMUNE SYSTEM; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SOMATIC MUTATION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

EID: 78649652518     PISSN: 17584272     EISSN: None     Source Type: Journal    
DOI: 10.2217/ijr.10.94     Document Type: Review

References (23)

1. Mackay IR, Burnet FM: Autoimmune Diseases: Pathogenesis, Chemistry and Therapy. Thomas CC (Ed.). Springfeld, IL, USA (1963).
2. Oldstone MBA: Molecular mimicry and immune-mediated diseases. FASEB J. 12, 1255-1265 (1998).
3. Kivity S, Agmon-Levin N, Blank M, Shoenfeld Y: Infections and autoimmunity-friends or foes? Trends Immunol. 30, 409-414 (2009).
4. Tsumiyama K, Miyazaki Y, Shiozawa S: Self-organized criticality theory of autoimmunity. PLoS ONE 4(12), e8382 (2009).
5. Paliard X, West SG, Lafferty JA et al.: Evidence for the effects of a superantigen in rheumatoid arthritis. Science 253, 325-329 (1991).
6. Curtsinger JM, Mescher MF: Infammatory cytokines as a third signal for T cell activation. Curr. Opin. Immunol. 22, 333-340 (2010).
7. + T cells. Immunol. Rev. 211, 81-92 (2006).
8. Chervonsky AV: Infuence of microbial environment on autoimmunity. Nat. Immunol. 11, 28-35 (2010).
9. Krangel M: T cell development: better living through chromatin. Nat. Immunol. 8, 687-694 (2007).
10. Skok JA, Gisler R, Novatchkova M, Farmer D, de Laat W, Busslinger M: Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes. Nat. Immunol. 8, 378-387 (2007).
11. Schlimgen RJ, Reddy KL, Singh H, Krangel MS: Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments. Nat. Immunol. 9, 802-809 (2008).
12. Hewagama A, Patel D, Yarlagadda S, Strickland FM, Richardson BC: Stronger infammatory/cytotoxic T-cell response in women identifed by microarray analysis: gender differences in T-cell gene expression. Gene Immun. 10, 509-516 (2009).
13. + T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J. Exp. Med. 186, 2057-2062 (1997).
14. + T cells after acute infection. Nat. Immunol. 5, 927-933 (2004).
15. + T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 52, 201-211 (2005).
16. + T lymphocytes among periglomerular infltrating cells and link to the prognosis of class III and class IV lupus nephritis. Arthritis Rheum. 56, 2362-2370 (2007).
17. + T cells and display an infammatory effector phenotype. J. Immunol. 183, 4675-4681 (2009).
18. Han JH, Akira S, Calame K et al.: Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity 27, 64-75 (2007).
19. Goodnow CC: Multistep pathogenesis of autoimmune disease. Cell 130, 25-35 (2007).
20. Nashi E, Wang YH, Diamond B: The role of B cells in lupus pathogenesis. Int. J. Biochem. Cell Biol. 42, 543-550 (2010).
21. Sherer Y, Gorstein A, Fritzler MJ, Shoenfeld Y: Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients. Sem. Arthritis Rheum. 34, 501-537 (2004).
22. Kastner D, Aksentijevich I, Goldbach-Mansky R: Autoinfammatory disease reloaded: a clinical perspective. Cell 140, 784-790 (2010).
23. Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y: Adjuvants and autoimmunity. Lupus 18, 1217-1225 (2009).