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Volumn 15, Issue 6, 2010, Pages 685-690

Minimization of immunosuppression in adult liver transplantation: New strategies and tools

Author keywords

adult liver transplantation; biomarkers; immunosuppression; tolerance

Indexed keywords

ALEMTUZUMAB; BIOLOGICAL MARKER; CD4 ANTIGEN; CD8 ANTIGEN; RAPAMYCIN; THYMOCYTE ANTIBODY;

EID: 78649648091     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e3283402c55     Document Type: Review
Times cited : (10)

References (46)
  • 1
    • 15744404866 scopus 로고    scopus 로고
    • Immunosuppressive drugs and the risk of cancer after organ transplantation
    • Dantal J, Soulillou JP. Immunosuppressive drugs and the risk of cancer after organ transplantation. N Engl J Med 2005; 352:1371-1373.
    • (2005) N Engl J Med , vol.352 , pp. 1371-1373
    • Dantal, J.1    Soulillou, J.P.2
  • 2
    • 0035668548 scopus 로고    scopus 로고
    • End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immuno-therapy: Risk of development and treatment
    • Gonwa TA, Mai ML, Melton LB, et al. End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immuno-therapy: risk of development and treatment. Transplantation 2001; 72: 1934-1939.
    • (2001) Transplantation , vol.72 , pp. 1934-1939
    • Gonwa, T.A.1    Mai, M.L.2    Melton, L.B.3
  • 3
    • 0033545299 scopus 로고    scopus 로고
    • Cyclosporine induces cancer pro-gression by a cell-autonomous mechanism
    • Hojo M, Morimoto T, Maluccio M, et al. Cyclosporine induces cancer pro-gression by a cell-autonomous mechanism. Nature 1999; 397:530-534.
    • (1999) Nature , vol.397 , pp. 530-534
    • Hojo, M.1    Morimoto, T.2    Maluccio, M.3
  • 4
    • 0017795772 scopus 로고
    • Tumors arising in organ transplant recipients
    • Penn I. Tumors arising in organ transplant recipients. Adv Cancer Res 1978; 28:31-61.
    • (1978) Adv Cancer Res , vol.28 , pp. 31-61
    • Penn, I.1
  • 5
    • 20844453255 scopus 로고    scopus 로고
    • Posttransplantdiabetes mellitus: Acase-control analysis of the risk factors
    • Romagnoli J, Citterio F, Violi P, et al. Posttransplantdiabetes mellitus: acase-control analysis of the risk factors. Transpl Int 2005; 18:309-312.
    • (2005) Transpl Int , vol.18 , pp. 309-312
    • Romagnoli, J.1    Citterio, F.2    Violi, P.3
  • 7
    • 0033809515 scopus 로고    scopus 로고
    • Long-term survival after liver transplantation in 4,000 consecutive patients at a single center
    • Jain A, Reyes J, Kashyap R, et al. Long-term survival after liver transplantation in 4,000 consecutive patients at a single center. Ann Surg 2000; 232:490-500.
    • (2000) Ann Surg , vol.232 , pp. 490-500
    • Jain, A.1    Reyes, J.2    Kashyap, R.3
  • 8
    • 77949321160 scopus 로고    scopus 로고
    • Protocol biopsies for renal transplantation
    • Rush D. Protocol biopsies for renal transplantation. Saudi J Kidney Dis Transpl 2010; 21:1-9.
    • (2010) Saudi J Kidney Dis Transpl , vol.21 , pp. 1-9
    • Rush, D.1
  • 9
    • 2942733581 scopus 로고    scopus 로고
    • Liver biopsy in evaluation of complications following liver transplantation
    • Yu YY, Ji J, Zhou GW, et al. Liver biopsy in evaluation of complications following liver transplantation. World J Gastroenterol 2004; 10:1678-1681.
    • (2004) World J Gastroenterol , vol.10 , pp. 1678-1681
    • Yu, Y.Y.1    Ji, J.2    Zhou, G.W.3
  • 10
    • 7044233641 scopus 로고    scopus 로고
    • A novel mechanism of liver allograft rejection facilitated by antibodies to liver sinusoidal endothelial cells
    • Sumitran-Holgersson S, Ge X, Karrar A, et al. A novel mechanism of liver allograft rejection facilitated by antibodies to liver sinusoidal endothelial cells. Hepatology 2004; 40:1211-1221.
    • (2004) Hepatology , vol.40 , pp. 1211-1221
    • Sumitran-Holgersson, S.1    Ge, X.2    Karrar, A.3
  • 11
    • 36649016030 scopus 로고    scopus 로고
    • Liver sinusoidal endothelial cell function in rejected and spontaneously accepted rat liver allografts
    • Ge X, Nowak G, Ericzon BG, Sumitran-Holgersson S. Liver sinusoidal endothelial cell function in rejected and spontaneously accepted rat liver allografts. Transpl Int 2008; 21:49-56.
    • (2008) Transpl Int , vol.21 , pp. 49-56
    • Ge, X.1    Nowak, G.2    Ericzon, B.G.3    Sumitran-Holgersson, S.4
  • 12
    • 46049112678 scopus 로고    scopus 로고
    • Role of Kupffercells in the induction oftolerance oforthotopic livertransplantation in rats
    • Chen Y, Liu Z, Liang S, et al. Role of Kupffercells in the induction oftolerance oforthotopic livertransplantation in rats. Liver Transpl 2008; 14:823-836.
    • (2008) Liver Transpl , vol.14 , pp. 823-836
    • Chen, Y.1    Liu, Z.2    Liang, S.3
  • 13
    • 40049104756 scopus 로고    scopus 로고
    • High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplanttolerance
    • Tokita D, Mazariegos GV, Zahorchak AF, et al. High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplanttolerance. Transplantation 2008; 85:369-377.
    • (2008) Transplantation , vol.85 , pp. 369-377
    • Tokita, D.1    Mazariegos, G.V.2    Zahorchak, A.F.3
  • 14
    • 41149155327 scopus 로고    scopus 로고
    • Relative contribution of direct and indirect allorecognition in developing tolerance after livertransplantation
    • Toyokawa H, Nakao A, Bailey RJ, et al. Relative contribution of direct and indirect allorecognition in developing tolerance after livertransplantation. Liver Transpl 2008; 14:346-357.
    • (2008) Liver Transpl , vol.14 , pp. 346-357
    • Toyokawa, H.1    Nakao, A.2    Bailey, R.J.3
  • 15
    • 19344373375 scopus 로고    scopus 로고
    • Tolerance in mixed chimerism: A role for regulatory cells?
    • Kurtz J, Wekerle T, Sykes M. Tolerance in mixed chimerism: a role for regulatory cells? Trends Immunol 2004; 25:518-523.
    • (2004) Trends Immunol , vol.25 , pp. 518-523
    • Kurtz, J.1    Wekerle, T.2    Sykes, M.3
  • 16
    • 34248146578 scopus 로고    scopus 로고
    • Allosuppressive donor CD4+CD25+ regulatory T cells detach from the graft and circulate in recipients after liver transplantation
    • Demirkiran A, Bosma BM, Kok A, et al. Allosuppressive donor CD4+CD25+ regulatory T cells detach from the graft and circulate in recipients after liver transplantation. J Immunol 2007; 178:6066-6072.
    • (2007) J Immunol , vol.178 , pp. 6066-6072
    • Demirkiran, A.1    Bosma, B.M.2    Kok, A.3
  • 17
    • 0036853026 scopus 로고    scopus 로고
    • Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease
    • Buhler LH, Spitzer TR, Sykes M, et al. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation 2002; 74:1405-1409.
    • (2002) Transplantation , vol.74 , pp. 1405-1409
    • Buhler, L.H.1    Spitzer, T.R.2    Sykes, M.3
  • 18
    • 38549088096 scopus 로고    scopus 로고
    • HLA-mismatched renal transplantation without maintenance immunosuppression
    • Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358:353-361.
    • (2008) N Engl J Med , vol.358 , pp. 353-361
    • Kawai, T.1    Cosimi, A.B.2    Spitzer, T.R.3
  • 19
    • 33750131777 scopus 로고    scopus 로고
    • Early immunosuppression withdrawal after living donor liver transplantation and donor stem cell infusion
    • Donckier V, Troisi R, Le Moine A, et al. Early immunosuppression withdrawal after living donor liver transplantation and donor stem cell infusion. Liver Transpl 2006; 12:1523-1528.
    • (2006) Liver Transpl , vol.12 , pp. 1523-1528
    • Donckier, V.1    Troisi, R.2    Le Moine, A.3
  • 20
    • 64649104649 scopus 로고    scopus 로고
    • Acute liver transplant rejection upon immunosuppression withdrawal in a tolerance induction trial: Potential role of IFN-gamma-secreting CD8+ T cells
    • Donckier V, Craciun L, Lucidi V, et al. Acute liver transplant rejection upon immunosuppression withdrawal in a tolerance induction trial: potential role of IFN-gamma-secreting CD8+ T cells. Transplantation 2009; 87 (Suppl 9):S91-S95.
    • (2009) Transplantation , vol.87 , Issue.SUPPL. 9
    • Donckier, V.1    Craciun, L.2    Lucidi, V.3
  • 21
    • 0032490341 scopus 로고    scopus 로고
    • Propetolerance, perioperativecampath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients
    • Calne R, Friend P, Moffatt S, et al. Propetolerance, perioperativecampath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet 1998; 351:1701-1702.
    • (1998) Lancet , vol.351 , pp. 1701-1702
    • Calne, R.1    Friend, P.2    Moffatt, S.3
  • 22
    • 0038298787 scopus 로고    scopus 로고
    • Tolerogenicimmunosuppression for organ transplantation
    • Starzl TE, Murase N, Abu-Elmagd K, et al.Tolerogenicimmunosuppressionfor organ transplantation. Lancet 2003; 361:1502-1710.
    • (2003) Lancet , vol.361 , pp. 1502-1710
    • Starzl, T.E.1    Murase, N.2    Abu-Elmagd, K.3
  • 23
    • 6344256213 scopus 로고    scopus 로고
    • Use of alemtuzumab and tacrolimus monotherapy for cadaveric liver transplantation: With particular reference to hepatitisCvirus
    • Marcos A, Eghtesad B, Fung JJ, et al. Use of alemtuzumab and tacrolimus monotherapy for cadaveric liver transplantation: with particular reference to hepatitisCvirus.Transplantation 2004; 78:966-991.
    • (2004) Transplantation , vol.78 , pp. 966-991
    • Marcos, A.1    Eghtesad, B.2    Fung, J.J.3
  • 25
    • 84900661521 scopus 로고    scopus 로고
    • ATG-Fresenius treatment and low dose tacrolimus: Results of a randomized controlled trial in liver transplantation
    • press
    • Benitez C. ATG-Fresenius treatment and low dose tacrolimus: results of a randomized controlled trial in liver transplantation. Am J Transplant (in press).
    • Am J Transplant
    • Benitez, C.1
  • 26
    • 0027469735 scopus 로고
    • Cell migration and chimerism: A unifying concept in transplantation-with particular reference to HLA matching and tolerance induction
    • Starzl TE. Cell migration and chimerism: a unifying concept in transplantation-with particular reference to HLA matching and tolerance induction. Trans-plant Proc 1993; 25:8-12.
    • (1993) Transplant Proc , vol.25 , pp. 8-12
    • Starzl, T.E.1
  • 27
    • 0030899508 scopus 로고    scopus 로고
    • Weaning of immunosuppression in livertransplant recipients
    • Mazariegos GV, Reyes J, Marino IR, et al. Weaning of immunosuppression in livertransplant recipients. Transplantation 1997; 63:243-249.
    • (1997) Transplantation , vol.63 , pp. 243-249
    • Mazariegos, G.V.1    Reyes, J.2    Marino, I.R.3
  • 28
    • 0031899420 scopus 로고    scopus 로고
    • Defining the outcome of immunosup-pression withdrawal after liver transplantation
    • Devlin J, Doherty D, Thomson L, et al. Defining the outcome of immunosup-pression withdrawal after liver transplantation. Hepatology 1998; 27:926-933.
    • (1998) Hepatology , vol.27 , pp. 926-933
    • Devlin, J.1    Doherty, D.2    Thomson, L.3
  • 29
    • 20344366308 scopus 로고    scopus 로고
    • Long-term outcome of immunosuppression withdrawal after liver transplantation
    • DOI 10.1016/j.transproceed.2005.03.070, PII S0041134505003088
    • Girlanda R, Rela M, Williams R, et al. Long-term outcome of immunosuppres-sion withdrawal after liver transplantation. Transplant Proc 2005; 37:1708-1709. (Pubitemid 40790804)
    • (2005) Transplantation Proceedings , vol.37 , Issue.4 , pp. 1708-1709
    • Girlanda, R.1    Rela, M.2    Williams, R.3    O'Grady, J.G.4    Heaton, N.D.5
  • 30
    • 0035079248 scopus 로고    scopus 로고
    • Analysis of alloreactivity and intragraft cytokine profiles in living donor liver transplant recipients with graft acceptance
    • Takatsuki M, Uemoto S, Inomata Y, et al. Analysis of alloreactivity and intragraft cytokine profiles in living donor liver transplant recipients with graft acceptance. Transpl Immunol 2001; 8:279-286.
    • (2001) Transpl Immunol , vol.8 , pp. 279-286
    • Takatsuki, M.1    Uemoto, S.2    Inomata, Y.3
  • 31
    • 18644364703 scopus 로고    scopus 로고
    • Tolerance: Is it worth the risk?
    • Eason JD, Cohen AJ, Nair S, et al. Tolerance: is it worth the risk? Transplanta-tion 2005; 79:1157-1159.
    • (2005) Transplantation , vol.79 , pp. 1157-1159
    • Eason, J.D.1    Cohen, A.J.2    Nair, S.3
  • 32
    • 20044361820 scopus 로고    scopus 로고
    • The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotrans-plantation
    • Tryphonopoulos P, Tzakis AG, Weppler D, et al. The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotrans-plantation. Am J Transplant 2005; 5:608-613.
    • (2005) Am J Transplant , vol.5 , pp. 608-613
    • Tryphonopoulos, P.1    Tzakis, A.G.2    Weppler, D.3
  • 33
    • 33644923002 scopus 로고    scopus 로고
    • Complete weaning off immuno-suppression in HCV liver transplant recipients is feasible and favourably impacts on the progression of disease recurrence
    • Tisone G, Orlando G, Cardillo A, et al. Complete weaning off immuno-suppression in HCV liver transplant recipients is feasible and favourably impacts on the progression of disease recurrence. J Hepatol 2006; 44:702-709.
    • (2006) J Hepatol , vol.44 , pp. 702-709
    • Tisone, G.1    Orlando, G.2    Cardillo, A.3
  • 34
    • 34250845839 scopus 로고    scopus 로고
    • Randomized controlled trial of total immunosuppression withdrawal in liver transplant recipients: Role of ursodeoxycholic acid
    • DOI 10.1097/01.tp.0000266678.32250.76, PII 0000789020070627000009
    • Assy N, Adams PC, Myers P, et al. Randomized controlled trial of total immunosuppression withdrawal in liver transplant recipients: role of urso-deoxycholic acid. Transplantation 2007; 83:1571-1576. (Pubitemid 46987908)
    • (2007) Transplantation , vol.83 , Issue.12 , pp. 1571-1576
    • Assy, N.1    Adams, P.C.2    Myers, P.3    Simon, V.4    Minuk, G.Y.5    Wall, W.6    Ghent, C.N.7
  • 35
    • 58149330244 scopus 로고    scopus 로고
    • FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal
    • Pons JA, Revilla-Nuin B, Baroja-Mazo A, et al. FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal. Transplantation 2008; 86: 1370-1378.
    • (2008) Transplantation , vol.86 , pp. 1370-1378
    • Pons, J.A.1    Revilla-Nuin, B.2    Baroja-Mazo, A.3
  • 36
    • 78650423557 scopus 로고    scopus 로고
    • ITN029ST: Immunosuppression withdrawal in pediatric recipients of parental living donor liver transplants: Preliminary results of a pilot study
    • Feng S, Ekong U, Lobritto S. ITN029ST: Immunosuppression withdrawal in pediatric recipients of parental living donor liver transplants: preliminary results of a pilot study. Am J Transplant 2009; 9(S2):abstract 189.
    • (2009) Am J Transplant , vol.9 , Issue.S2 , pp. 189
    • Feng, S.1    Ekong, U.2    Lobritto, S.3
  • 37
    • 78649641477 scopus 로고    scopus 로고
    • Use of transcriptional biomar-kers to identify liver transplant recipients who can successfully discontinue immunosuppressive therapy
    • Benitez C, Lozano JJ, Mart́inez-Llordella M. Use of transcriptional biomar-kers to identify liver transplant recipients who can successfully discontinue immunosuppressive therapy. Am J Transplant 2010; 10(S4):abstract 517.
    • (2010) Am J Transplant , vol.10 , Issue.S4 , pp. 517
    • Benitez, C.1    Lozano, J.J.2    Mart́inez-Llordella, M.3
  • 38
    • 33745804056 scopus 로고    scopus 로고
    • An appraisal of tolerance in liver transplantation
    • Lerut J, Sanchez-Fueyo A. An appraisal of tolerance in liver transplantation. Am J Transplant 2006; 6:1774-1780.
    • (2006) Am J Transplant , vol.6 , pp. 1774-1780
    • Lerut, J.1    Sanchez-Fueyo, A.2
  • 39
    • 33747080802 scopus 로고    scopus 로고
    • Liver biopsyinterpretationforcauses of late liver allograft dysfunction
    • Demetris AJ, Adeyi O, Bellamy CO, et al. Liver biopsyinterpretationforcauses of late liver allograft dysfunction. Hepatology 2006; 44:489-501.
    • (2006) Hepatology , vol.44 , pp. 489-501
    • Demetris, A.J.1    Adeyi, O.2    Bellamy, C.O.3
  • 40
    • 57349101055 scopus 로고    scopus 로고
    • Monitoring of human liver and kidney allograft tolerance: A tissue/histopathology perspective
    • Demetris AJ, Lunz JG 3rd, Randhawa P, et al. Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective. Transpl Int 2009; 22:120-141.
    • (2009) Transpl Int , vol.22 , pp. 120-141
    • Demetris, A.J.1    Lunz III, J.G.2    Randhawa, P.3
  • 41
    • 65649106140 scopus 로고    scopus 로고
    • Requirement of protocol biopsy before and after complete cessation of immunosuppression after liver transplantation
    • Yoshitomi M, Koshiba T, Haga H, et al. Requirement of protocol biopsy before and after complete cessation of immunosuppression after liver transplantation.Transplantation 2009; 87:606-614.
    • (2009) Transplantation , vol.87 , pp. 606-614
    • Yoshitomi, M.1    Koshiba, T.2    Haga, H.3
  • 43
    • 33846252277 scopus 로고    scopus 로고
    • Multiparameter immune profiling of operational tolerance in liver transplantation
    • Martínez-Llordella M, Puig-Pey I, Orlando G, et al. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant 2007; 7:309-319.
    • (2007) Am J Transplant , vol.7 , pp. 309-319
    • Martínez-Llordella, M.1    Puig-Pey, I.2    Orlando, G.3
  • 44
    • 48749084927 scopus 로고    scopus 로고
    • Usingtranscriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients
    • Mart́inez-Llordella M, Lozano JJ, Puig-Pey I, et al. Usingtranscriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. J Clin Invest 2008; 118:2845-2857.
    • (2008) J Clin Invest , vol.118 , pp. 2845-2857
    • Mart́inez-Llordella, M.1    Lozano, J.J.2    Puig-Pey, I.3
  • 45
    • 41049115576 scopus 로고    scopus 로고
    • Gene expression profile analysis of the peripheral blood mononuclear cells from tolerant living-donor liver trans-plant recipients
    • Kawasaki M, Iwasaki M, Koshiba T, et al. Gene expression profile analysis of the peripheral blood mononuclear cells from tolerant living-donor liver trans-plant recipients. Int Surg 2007; 92:276-286.
    • (2007) Int Surg , vol.92 , pp. 276-286
    • Kawasaki, M.1    Iwasaki, M.2    Koshiba, T.3
  • 46
    • 58849121453 scopus 로고    scopus 로고
    • The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipients
    • Li Y, Zhao X, Cheng D, et al. The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipients. Transplantation 2008; 86:1837-1843.
    • (2008) Transplantation , vol.86 , pp. 1837-1843
    • Li, Y.1    Zhao, X.2    Cheng, D.3


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