Gene expression profile analysis of the peripheral blood mononuclear cells from tolerant living-donor liver transplant recipients

International Surgery

Volumn 92, Issue 5, 2007, Pages 276-286

  Kawasaki, Mikiko ^a,b   Iwasaki, Minoru ^c   Koshiba, Takaaki ^c   Fujino, Masayuki ^a   Hara, Yoshiaki ^a   Kitazawa, Yusuke ^a   Kimura, Hiromitsu ^a   Nomura, Koh ^b   Uemoto, Shinji ^d   Li, Xiao Kang ^a   Tanaka, Koichi ^c  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d MIE UNIVERSITY   (Japan)

Author keywords

Gene expression; Living donor liver transplantation; Microarray; Regulatory lymphocytes; Tolerance

Indexed keywords

ARTICLE; BLOOD CELL; CHILD; DNA MICROARRAY; FEMALE; GENE EXPRESSION PROFILING; GENETICS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INFANT; LIVER TRANSPLANTATION; LIVING DONOR; MALE; MONONUCLEAR CELL; PRESCHOOL CHILD;

BLOOD CELLS; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION PROFILING; HUMANS; IMMUNE TOLERANCE; INFANT; LEUKOCYTES, MONONUCLEAR; LIVER TRANSPLANTATION; LIVING DONORS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 41049115576     PISSN: 00208868     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Pascual M, Theruvath T, Kawai T, Tolkoff-Rubin N, Cosimi AB. Strategies to improve long-term outcomes after renal transplantation. N Engl J Med 2002;346:580-590
2. Dong VM, Womer KL, Sayegh MH. Transplantation tolerance: the concept and its applicability. Pediatr Transplant 1999;3:181-192
3. Matthews JB, Ramos E, Bluestone JA. Clinical trials of transplant tolerance: slow but steady progress. Am J Transplant 2003;3:794- 803
4. Starzl TE, Demetris AJ, Murase N, Thomson AW, Trucco M, Ricordi C. Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation. Immunol Today 1993;14:326-332
5. Takatsuki M, Uemoto S, Inomata Y, Egawa H, Kiuchi T, Fujita S et al. Weaning of immunosuppression in living donor liver transplant recipients. Transplantation 2001;72:449-454
6. Inomata Y, Tanaka K, Egawa H, Uemoto S, Ozaki N, Okajima H et al. The evolution of immunosuppression with FK506 in pediatric living-related liver transplantation. Transplantation 1996;61:247-252
7. Luo L, Salunga RC, Guo H, Bittner A, Joy KC, Galindo JE et al. Gene expression profiles of laser-captured adjacent neuronal subtypes. Nat Med 1999;5:117-122
8. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003;3:199-210
9. Guo L, Fujino M, Kimura H, Funeshima N, Kitazawa Y, Harihara Y et al. Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation. Transpl Immunol 2003;12:41-48
10. Guo L, Fujino M, Kimura H, Funeshima N, Kitazawa Y, Harihara Y et al. AdCTLA-4Ig combined with donor splenocytes, bone marrow cells and anti-ICOS antibody treatment induce tolerance in a rat heart transplantation model. Transplant Int 2004;17:15-21
11. Fujino M, Kitazawa Y, Kawasaki M, Funeshima N, Kimura H, Nakajima T et al. Differences in lymphocyte gene expression between tolerant and syngeneic liver grafted rats. Liver Transplant 2004;10:379-391
12. Li Y, Koshiba T, Yoshizawa A, Yonekawa Y, Masuda K, Ito A et al. Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. Am J Transplant 2004;4:2118-2125
13. Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV et al. Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. Ann Neurol 1999;46:425-428
14. Zou TT, Selaru FM, Xu Y, Shustova V, Yin J, Mori Y et al. Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon. Oncogene 2002;21:4855-4862
15. Amatschek S, Koenig U, Auer H, Steinlein P, Pacher M, Gruenfelder A et al. Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumor-specific genes. Cancer Res 2004;64:844-856
16. Tapper J, Kettunen E, El-Rifai W, Seppala M, Andersson LC, Knuutila S. Changes in gene expression during progression of ovarian carcinoma. Cancer Genet Cytogenet 2001;128:1-6
17. Moos PJ, Raetz EA, Carlson MA, Szabo A, Smith FE, Willman C et al. Identification of gene expression profiles that segregate patients with childhood leukemia. Clin Cancer Res 2002;8: 3118-3130
18. Fukuhara Y, Hirasawa A, Li XK, Kawasaki M, Fujino M, Funeshima N et al. Gene expression profile in the regenerating rat liver after partial hepatectomy. J Hepatol 2003;38:784-792
19. Frank MM, Fries LF. The role of complement in inflammation and phagocytosis. Immunol Today 1991;12:322-326
20. Tomlinson S. Complement defense mechanisms. Curr Opin Immunol 1993;5:83-89
21. Carroll MC. The role of complement and complement receptors in induction and regulation of immunity. Annu Rev Immunol 1998;16:545-568
22. Dempsey PW, Allison ME, Akkaraju S, Goodnow CC, Fearon DT. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 1996;271:348-350
23. Jacquier-Sarlin MR, Gabert FM, Villiers MB, Colomb MG. Modulation of antigen processing and presentation by covalently linked complement C3b fragment. Immunology 1995; 84:164-170
24. Sohn JH, Bora PS, Suk HJ, Molina H, Kaplan HJ, Bora NS. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Nat Med 2003;9:206-212
25. Prodeus AP, Goerg S, Shen LM, Pozdnyakova OO, Chu L, Alicot EM et al. A critical role for complement in maintenance of self-tolerance. Immunity 1998;9:721-731
26. Pratt JR, Basheer SA, Sacks SH. Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med 2002;8:582-587
27. Sanchez-Fueyo A, Domenig C, Strom TB, Zheng XX. The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression. Transplantation 2002;74:898-900
28. Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 2000;403:211-216
29. Jeon MS, Atfield A, Venuprasad K, Krawczyk C, Sarao R, Elly C et al. Essential role of the E3 ubiquitin ligase Cb1-b in T cell anergy induction. Immunity 2004;21:167-177
30. Nishibori T, Tanabe Y, Su L, David M. Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J Exp Med 2004;199:25-34
31. Quong MW, Romanow WJ, Murre C. E protein function in lymphocyte development. Annu Rev Immunol 2002;20:301-322
32. Pan L, Sato S, Frederick JP, Sun XH, Zhuang Y. Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. Mol Cell Biol 1999;19:5969-5980
33. Heemskerk MH, Blom B, Nolan G, Stegmann AP, Bakker AQ, Weijer K et al. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J Exp Med 1997;186:1597-1602
34. Chua MS, Sarwal MM. Microarrays: new tools for transplantation research. Pediatr Nephrol 2003;18:319-327
35. Hernandez-Fuentes MP, Warrens AN, Lechler RI. Immunologic monitoring. Immunol Rev 2003;196:247-264