Low tryptophan levels are associated with postoperative delirium in the elderly

American Journal of Surgery

Volumn 196, Issue 5, 2008, Pages 670-674

  Robinson, Thomas N ^a,b   Raeburn, Christopher D ^a,b   Angles, Erik M ^a,b   Moss, Marc ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Delirium; Geriatric; Postoperative; Surgery; Tryptophan

Indexed keywords

TRYPTOPHAN;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; DELIRIUM; DISEASE DURATION; FEMALE; GERIATRIC PATIENT; HUMAN; INCIDENCE; INTENSIVE CARE; MALE; OBSERVATIONAL STUDY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY;

AGED; CHI-SQUARE DISTRIBUTION; DELIRIUM; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; TRYPTOPHAN;

EID: 54049091590     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2008.07.007     Document Type: Article

References (18)

1. Marcantonio E.R., Goldman L., Mangione C.M., et al. A clinical prediction rule for delirium after elective noncardiac surgery. JAMA 271 (1994) 134-139
2. Geriatric Review Syllabus-A Core Curriculum in Geriatric Medicine. 6th ed. (2006), American Geriatrics Society, New York
3. Pandharipande P., Jackson J., and Ely E.W. Delirium: acute cognitive dysfunction in the critically ill. Curr Opin Crit Care 11 (2005) 360-368
4. van der Mast R.C., van den Broek W.W., Fekkes D., et al. Is delirium after cardiac surgery related to plasma amino acids and physical condition?. J Neuropsychiatry Clin Neurosci 12 (2000) 57-63
5. Markus C.R., Olivier B., Panhuysen G.E., et al. The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am J Clin Nutr 71 (2000) 1536-1544
6. Murphy S.E., Longhitano C., Ayres R.E., et al. Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers. Psychopharmacology 187 (2006) 121-130
7. Uchida K., Aoki T., and Ishizuka B. Postoperative delirium and plasma melatonin. Med Hypotheses 53 (1999) 103-106
8. Marcantonio E.R., Rudolph J.L., Culley D., et al. Serum biomarkers for delirium. J Gerontol A Biol Sci Med Sci 61 (2006) 1281-1286
9. Borson S., Scanlan J.M., Chen P., et al. The mini-cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc 51 (2003) 1451-1454
10. Mahoney F.I., and Barthel D.W. Functional evaluation: the Barthel index. Md State Med J 14 (1965) 61-65
11. Charlson M.E., Pompei P., Ales K.L., et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40 (1987) 373-383
12. Ely E.W., Margolin R., Francis J., et al. Evaluation of delirium in critically ill patients: validation of the confusion assessment method for the intensive care unit (CAM-ICU). Crit Care Med 29 (2001) 1370-1379
13. Pisani M.A., Araujo K.L., Van Ness P.H., et al. A research algorithm to improve detection of delirium in the intensive care unit. Crit Care 10 (2006) R121
14. Amirkhani A., Heldin E., Markides K.E., et al. Quantitation of tryptophan, kynurenine and kynurenic acid in human plasma by capillary liquid chromatography-electrospray ionization tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 780 (2002) 381-387
15. Flacker J.M., and Lipsitz L.A. Large neutral amino acid changes and delirium in febrile elderly medical patients. J Gerontol A Biol Sci Med Sci 55 (2000) B24954
16. Satz P. Brain reserve capacity on symptom onset after brain injury: a formulation and review of evidence for threshold theory. Neuropsychology 7 (1993) 273-295
17. Thomas D.E., Chung A.O.K.O., Dickerson J.W., et al. Tryptophan and nutritional status of patients with senile dementia. Psychol Med 16 (1986) 297-305
18. van der Mast R.C., Fekkes D., Moleman P., et al. Is postoperative delirium related to reduced plasma tryptophan?. Lancet 338 (1991) 851-852