Controlled crystallization of the lipophilic drug fenofibrate during freeze-drying: Elucidation of the mechanism by in-line raman spectroscopy

AAPS Journal

Volumn 12, Issue 4, 2010, Pages 569-575

  De Waard, Hans ^a   De Beer, Thomas ^b   Hinrichs, Wouter L J ^a   Vervaet, Chris ^b   Remon, Jean Paul ^b   Frijlink, Henderik W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Dissolution; Fenofibrate; Nanocrystal; Poorly water soluble drug; Raman spectroscopy

Indexed keywords

FENOFIBRATE; SOLVENT;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SOLUBILITY; FREEZE DRYING; LOW TEMPERATURE; PHYSICAL CHEMISTRY; RAMAN SPECTROMETRY; SOLUTE; TABLET FORMULATION; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; FENOFIBRATE; FREEZE DRYING; HYPOLIPIDEMIC AGENTS; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTRUM ANALYSIS, RAMAN; TABLETS; X-RAY DIFFRACTION;

EID: 78649647329     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-010-9215-z     Document Type: Article

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