Implementation of a process analytical technology system in a freeze-drying process using Raman spectroscopy for in-line process monitoring

Analytical Chemistry

Volumn 79, Issue 21, 2007, Pages 7992-8003

  De Beer, T R M ^a   Alleso M ^b   Goethals, F ^a   Coppens, A ^a   Vander Heyden, Y ^c   Lopez De Diego, H ^d   Rantanen, J ^b   Verpoort, F ^a   Vervaet, C ^a   Remon, J P ^a   Baeyens, W R G ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c PHARMACEUTICAL INSTITUTE   (Belgium)

^d H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEATION; PRINCIPAL COMPONENT ANALYSIS; PROCESS MONITORING; RAMAN SPECTROSCOPY; REAL TIME SYSTEMS; SODIUM CHLORIDE; X RAY POWDER DIFFRACTION;

FACTORIAL DESIGN; FREEZE DRYING PROCESS; ICE NUCLEATION; MANNITOL SOLID STATES;

DRYING;

MANNITOL; SODIUM CHLORIDE;

ARTICLE; FREEZE DRYING; FREEZING; NEAR INFRARED SPECTROSCOPY; PROCESS MONITORING; RAMAN SPECTROMETRY; SOLID STATE; TECHNOLOGY; X RAY POWDER DIFFRACTION;

FREEZE DRYING; MANNITOL; POWDER DIFFRACTION; SENSITIVITY AND SPECIFICITY; SODIUM CHLORIDE; SOLUTIONS; SPECTROSCOPY, NEAR-INFRARED; SPECTRUM ANALYSIS, RAMAN;

EID: 35848946390     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac070549h     Document Type: Article

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