Acute and subacute toxicity studies of Persea americana Mill (Avocado) seed in rats

International Journal of Medical Toxicology and Legal Medicine

Volumn 11, Issue 2, 2008, Pages 31-36

  Taha, Nael Abu ^a,b,c   Alkhawajah, A Aziz M ^b   Raveesha, K K ^c  

^a Department of Botany   (India)

^b IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF MYSORE   (India)

Author keywords

Acute toxicity; Avocado; Clinical chemistry; Persea americana; Subacute toxicity

Indexed keywords

ANTIINFECTIVE AGENT; BILIRUBIN; CHOLESTEROL; CREATININE; GLUCOSE; HEMOGLOBIN; PERSEA AMERICANA EXTRACT; PLANT EXTRACT; PROTEIN; UNCLASSIFIED DRUG; URIC ACID;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVOCADO; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; LD 50; MALE; NONHUMAN; PLANT SEED; PROTEIN BLOOD LEVEL; RAT;

PERSEA AMERICANA; RATTUS;

EID: 78649646345     PISSN: 09720448     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Lewis, CE, Morris R, O'Brien K. The oil content of avocado mesocarp, J. Sci. Food Agric. 1978;29:943-949.
2. Hierro MT,Tomas MC, Fernandez-Martin F, Santa-Maria G. Determination of the triglyceride composition of avocado oil by high-performance liquid chromatography using a light- scattering detector. J. Chromatogr. 1992;607:329-338.
3. Hargis AM, Stauber E, Casteel S, Eitner D. Avocado (Persea americana) intoxication in caged birds. J Am Vet Med Assoc. 1989;194(1):64-6.
4. Stadler P, van Rensburg IB, Naudé TW. Suspected avocado (Persea americana) poisoning in goats. J S Afr Vet Assoc. 1991;62(4):186-8.
5. McKenzie RA, Brown OP. Avocado (Persea americana) poisoning of horses. Aust Vet J. 1991; 68(2):77-8.
6. Buoro IB, Nyamwange SB, Chai D Nunyua SM. Putative avocado Toxicity in Two Dogs. Onnderstepoort J Vet Res. 1994; 61(1) : 107-9.
7. Pamplona - Roger GD. Encyclopedia of Medicinal plant. Spain Grafica Reunide. Vol.2.1999
8. Morton J. Avocado. In fruits of warm climates. ed.Julia F. Morton, Miami FL. 1987;91-102.
9. Rodriquez-Saona C, Trumble JT. Biologically active aliphatic acetogenins from specialized Idioblast oil cells. Curr Org Chem. 2000;4: 1249-60.
10. Domergue F, Helms GL, Prusky D, Browse J. Antifungal compounds from Idioblast cells isolated form avocado fruits. J. Phytochem.2004;54:183.
11. Ojewole JA, Amabeoku GJ. Anticonvulsant effect of Persea americana Mill. (lauraceae) avocado leaf aqueous extract in mice. Phytother. Res. 2006;20:696-700.
12. Argueta A, Cano L, Rodarte M. Atlas de las Plantas de laMedicina Tradicional Mexicana. Instituto Nacional Indigenista,Mexico.1994.
13. Cabrera L. Tratado de Plantas Curativas de Mexico. Editores Mexicanos Unidos, Mexico.1996.
14. Fransworth NR, Akerele O, Bingel AS. Medicinal plants in therapy. Bull. WHO 1985;63:965-981.
15. Gammaniel KS. Toxicity from medicinal plants and their product Nig. J. Prod. Med. 2000;4: 4-8.
16. OECD (Organisation for Economic Co-operation and Development),1998. Series on Principles of 2 Good Laboratory Practice and Compliance Monitoring, No. 1, adopted 13 November 1998, Paris.
17. Miller LC, Tainter ML. Estimation of LD50 and its errors by means of Log-Probit graph paper. Proc. Soc. Exp. Biol. Med. 1994;57: 261-267.
18. World Health Organization Expert Committee in diabetes mellitus. Tech Rep Series 1980.
19. Peters JP, and Vanslyke DD. Quantitative Clinical Chemistry. Williams and Wilkins,Baltimore, 1946.
20. Clarke EG, Clarke ML. Veterinary toxicology. 3rd edition, Bailliere Tindal, New York,1975.
21. McNamara BP. Concept in health evaluation of commercial and industrial chemicals in: Mehlman MA, Shaprio R.E, Blumental, H. (Eds). New concepts in safety evaluation. Hemisphere, Washington DC, 1976.
22. Lorke D. A new approach to practical acute toxicity testing. Arch. Toxicology.1983;54:275-287.
23. Timbrel J. Principles of biochemical toxicology, 3rd edition Taylor and Francis, London, 2002.
24. Range HP, Dale M, Ritter J. Pharmacology, 4th ed. (USA ed), New York, Churchill Livingstone, 2001.
25. Naveh E, Werman MJ, Sabo E, Neeman I. Defatted avocado pulp reduces body weight and total hepatic fat but increases plasma cholesterol in male rats fed diets with cholesterol. J. Nutr. 2002;132 (7): 2015-8. (Pubitemid 34742893)
26. Young NS and Maciejewski J. The path physiology of acquired a plastic anemia. New Eng. J. Med. 1977;336:1365.
27. Anitia BS, Okokon JE, Okon PA. Hypoglycemic activity of aqueous leaf extract of Persea americana Mill. Indian J. Pharmacol. 2005;37:325-326.
28. Marles RJ, Farnsweorth NR. Antidiabetic plants and their active constituents. Phytomedicine. 1995;2,137-189.
29. nd ed. Philadelphia, London,1974
30. th ed. Lippincott Williams and Wilkins, A wotlers kluwer company, 2004.
31. Brai BI C, Odetola AA and Agomo PU. Effects of Persea americana leaf extracts on body weight and liver lipids in rats fed hyperlipidaemic diet. Afr. J. Biotechnol. 2007;6 (8),1007-1011.
32. Srinivasan K, Sambaiah K. The effect of spices on cholesterol 7-á hydroxylase activity and on serum and hepatic cholesterol level in rats. Int. J. Nutr. Res. 1997;61:364-369.