Negative vaccination by tolerogenic dendritic cells in organ transplantation

Current Opinion in Organ Transplantation

Volumn 15, Issue 6, 2010, Pages 738-743

  Hill, Marcelo ^a,b,c,d   Cuturi, Maria C ^a,b,c  

^a HÔTEL DIEU   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

Author keywords

autologous tolerogenic dendritic cells; cell therapy; transplantation

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA; TRYPTOPHAN 2,3 DIOXYGENASE;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIGEN SPECIFICITY; AUTOTRANSPLANTATION; BONE MARROW; CELL THERAPY; DENDRITIC CELL; DONOR SELECTION; GRAFT SURVIVAL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; NATURAL KILLER T CELL; NONHUMAN; ORGAN TRANSPLANTATION; REVIEW; TISSUE ENGINEERING; VACCINATION;

ANIMALS; DENDRITIC CELLS; GRAFT SURVIVAL; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; MICE; ORGAN TRANSPLANTATION; PRIMATES; RATS; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, AUTOLOGOUS; VACCINATION;

EID: 78649641628     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e32833f7114     Document Type: Review

References (38)

1. Lechler RI, Sykes M, Thomson AW, Turka LA. Organ transplantation: how much of the promise has been realized? Nat Med 2005; 11:605-613.
2. Dantal J, Hourmant M, Cantarovich D, et al. Effect of long-term immunosup-pression in kidney-graft recipients on cancer incidence: randomised compar-ison of two cyclosporin regimens. Lancet 1998; 351:623-628.
3. Bluestone JA, Thomson AW, Shevach EM, Weiner H L. What does the future hold for cell-based tolerogenic therapy? Nat Rev Immunol 2007; 7:650-654.
4. Morelli AE, Thomson AW. Tolerogenic dendritic cells and the quest for transplanttolerance. Nat Rev Immunol 2007; 7:610-621.
5. Moreau A, Hill M,Thebault P, et al.Tolerogenic dendriticcellsactively inhibitT cellsthrough hemeoxygenase-1 in rodentsand nonhuman primates. Faseb J 2009; 23:3070-3077.
6. Ouabed A, Hubert FX, Chabannes D, et al. Differential control of T regulatory cell proliferation and suppressive activity by mature plasmacy-toid versus conventional spleen dendritic cells. J Immunol 2008; 180: 5862-5870.
7. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21:685-711.
8. Remy S, Blancou P, Tesson L, et al. Carbon monoxide generated by heme oxygenase activity confers tolerogenic capacity to dendritic cells. J Immunol 2009; 182:1877-1884.
9. Ilarregui JM, Croci DO, Bianco GA, et al. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 2009; 10:981-991.
10. Luckashenak N,Schroeder S, Endt K, et al. Constitutivecross-presentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. Immunity 2008; 28:521-532.
11. Ohnmacht C, Pullner A, King S, et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 2009; 206:549-559.
12. Ochando J, Homma C, Yang Y, et al. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol 2006; 7:652-662.
13. Steinman R, Banchereau J. Taking dendritic cells into medicine. Nature 2007; 449:419-426.
14. Peche H, Trinite B, Martinet B, Cuturi MC. Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors. Am J Transplant 2005; 5:255-267.
15. Beriou G, Peche H, Guillonneau C, et al. Donor-specific allografttolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression. Transplantation 2005; 79:969-972.
16. Segovia M, Cuturi MC, Hill M. Preparation of mouse bone marrow-derived dendritic cells with immunoregulatory properties. In Suppression and regula-tion of immune responses. Methods in Molecular Biology 2010; vol. 677, Springer.
17. Tan JK, O'Neill HC. Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity. J Leukoc Biol 2005; 78:319-324.
18. Chauveau C, Remy S, Royer PJ, et al. Heme oxygenase-1 expression inhibits dendritic cell maturation and pro-inflammatory function but conserves IL-10 expression. Blood 2005; 106:1694-1702.
19. Mellor AL, Munn DH. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004; 4:762-774.
20. Shortman K, Heath WR. Immunity or tolerance? That is the question for dendritic cells. Nat Immunol 2001; 2:988-989.
21. Gould D, Auchincloss HJ. Direct and indirect recognition: the role of MHC antigens in graft rejection. Immunol Today 1999; 20:77-82.
22. Herrera OB, Golshayan D, Tibbott R, et al. A novel pathway of alloantigen presentation by dendritic cells. J Immunol 2004; 173:4828-4837.
23. Josien R, Heslan M, Brouard S, et al. Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion. Blood 1998; 92:4539-4544.
24. Guillot C, Menoret S, Guillonneau C, et al. Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival byCTLA4Ig. Blood 2003; 101:3325-3333.
25. Li X, Menoret S, Bezie S, et al. Mechanism and localization of CD8 regulatory T cells in a heart transplant model of tolerance. J Immunol 2010; 185:823-833.
26. Bonifaz L, Bonnyay D, Mahnke K, et al. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I pro-ducts and peripheral CD8+T cell tolerance. J Exp Med 2002; 196:1627-1638.
27. Hackstein H, Thomson AW. Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol 2004; 4:24-34.
28. Everly J, Walsh R, Alloway R, Woodle E. Proteasome inhibition for antibody-mediated rejection. Curr Opin Organ Transplant 2009; 14: 662-666.
29. Moreau A, Chiffoleau E, Beriou G, et al. Superiority of bone marrow-derived dendritic cells over monocyte-derived ones for the expansion of regulatory T cells in the macaque. Transplantation 2008; 85:1351-1356.
30. Lutz MB, Suri RM, Niimi M, et al. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival invivo. Eur J Immunol 2000;30:1813-1822.
31. Chitta S, Santambrogio L, Stern LJ. GMCS Fin the absence of other cytokines sustains human dendritic cell precursors with T cell regulatory activity and capacity to differentiate into functional dendritic cells. Immunol Lett 2008; 116:41-54.
32. Yu G, Xu X, Vu MD, et al. NK cells promote transplant tolerance by killing donorantigen-presenting cells.J Exp Med 2006; 203:1851-1858.
33. Griffith LM, Pavletic SZ, Tyndall A, et al. Feasibility of allogeneic hema-topoietic stem cell transplantation for autoimmune disease: position state-ment from a National Institute of Allergy and Infectious Diseases and National Cancer Institute-Sponsored International Workshop, Bethesda, MD, March 12 and 13, 2005. Biol Blood Marrow Transplant 2005; 11: 862-870.
34. Dhodapkar M, Steinman RM, Krasovsky J, et al. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 2001; 193:233-238.
35. Gokmen MR, Lombardi G, Lechler RI. The importance of the indirect pathway of allorecognition in clinical transplantation. Curr Opin Immunol 2008; 20:568-574.
36. Peche H, Renaudin K, Beriou G, et al. Induction oftolerance byexosomesand short-term immunosuppression in a fully MHC-mismatched rat cardiac allo-graft model. Am J Transplant 2006; 6:1541-1550.
37. Yang J, Bernier S I, Ichim T E, et al. LF15-0195 generatestolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity. J Leukoc Biol 2003; 74:438-447.
38. Min W, Zhou D, Ichim T, et al. Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol 2003; 170:1304-1312.