Amplification of thymidylate synthetase in metastatic colorectal cancer patients pretreated with 5-fluorouracil-based chemotherapy

European Journal of Cancer

Volumn 46, Issue 18, 2010, Pages 3358-3364

  Watson, Roshawn G ^a   Muhale, Filipe ^a   Thorne, Leigh B ^b   Yu, Jinsheng ^c   O'Neil, Bert H ^b,d   Hoskins, Janelle M ^a   Meyers, Michael O ^b   Deal, Allison M ^d   Ibrahim, Joseph G ^e   Hudson, Michael L ^f   Walko, Christine M ^a   McLeod, Howard L ^a,b,d   Auman, James T ^a  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e University of North Carolina at Chapel Hill   (United States)

^f CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Colorectal neoplasms; DNA copy number variation; Fluorouracil; Neoplasm metastasis; Thymidine phosphorylase; Thymidylate synthase

Indexed keywords

FLUOROURACIL; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; COPY NUMBER VARIATION; DRUG METABOLISM; FEMALE; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUOROURACIL; GENE AMPLIFICATION; HUMANS; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE;

EID: 78649591408     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.07.011     Document Type: Article

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