메뉴 건너뛰기




Volumn 1, Issue 2, 2001, Pages 133-139

Combination of thymidine phosphorylase gene transfer and deoxyinosine treatment greatly enhances 5-fluorouracil antitumor activity in vitro and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYINOSINE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUOROURACIL; INOSINE; PYRIMIDINE NUCLEOTIDE; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE; TRITIUM;

EID: 0035554258     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (27)

References (46)
  • 1
    • 0015373687 scopus 로고
    • Fluorinated pyrimidines. XL. The reduction of 5-fluorouridine 5′-diphosphate by ribonucleotide reductase
    • Kent, R. J., and Heidelberger, C. Fluorinated pyrimidines. XL. The reduction of 5-fluorouridine 5′-diphosphate by ribonucleotide reductase. Mol. Pharmacol., 8: 465-475, 1972.
    • (1972) Mol. Pharmacol. , vol.8 , pp. 465-475
    • Kent, R.J.1    Heidelberger, C.2
  • 2
    • 0022656553 scopus 로고
    • Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes
    • Peters, G. J., Laurensse, E., Leyva, A., Lankelma, J., and Pinedo, H. M. Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5′-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes. Cancer Res., 46: 20-28, 1986. (Pubitemid 16189022)
    • (1986) Cancer Research , vol.46 , Issue.1 , pp. 20-28
    • Peters, G.J.1    Laurensse, E.2    Leyva, A.3
  • 3
    • 0026045814 scopus 로고
    • A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa
    • Phila.
    • Peters, G. J., Van Groeningen, C. J., Laurensse, E. J., and Pinedo, H. M. A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa. Cancer (Phila.), 68: 1903-1309, 1991.
    • (1991) Cancer , vol.68 , pp. 1903-11309
    • Peters, G.J.1    Van Groeningen, C.J.2    Laurensse, E.J.3    Pinedo, H.M.4
  • 5
    • 0019807257 scopus 로고
    • 5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity
    • Kufe, D. W., and Major, P. P. 5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity. J. Biol. Chem., 256: 9802-9805, 1981. (Pubitemid 12176177)
    • (1981) Journal of Biological Chemistry , vol.256 , Issue.19 , pp. 9802-9805
    • Kufe, D.W.1    Major, P.P.2
  • 6
    • 0028657658 scopus 로고
    • Enhanced cytotoxicity with interleukin-1α and 5-fluorouracil in HCT116 colon cancer cells
    • Geoffroy, F. J., Allegra, C. J., Sinha, B., and Grem, J. L. Enhanced cytotoxicity with interleukin-1α and 5-fluorouracil in HCT116 colon cancer cells. Oncol. Res., 6: 581-591, 1994.
    • (1994) Oncol. Res. , vol.6 , pp. 581-591
    • Geoffroy, F.J.1    Allegra, C.J.2    Sinha, B.3    Grem, J.L.4
  • 8
    • 0028210793 scopus 로고
    • Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase
    • Schwartz, E. L., Baptiste, N., O'Connor, C. J., Wadler, S., and Otter, B. Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase. Cancer Res., 54: 1472-1478, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 1472-1478
    • Schwartz, E.L.1    Baptiste, N.2    O'Connor, C.J.3    Wadler, S.4    Otter, B.5
  • 9
    • 0029051690 scopus 로고
    • Thymidine phosphorylase mediates the sensitivity of human colon carcinoma cells to 5-fluorouracil
    • Schwartz, E. L., Baptiste, N., Wadler, S., and Makower, D. Thymidine phosphorylase mediates the sensitivity of human colon carcinoma cells to 5-fluorouracil. J. Biol. Chem., 270: 19073-19077, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19073-19077
    • Schwartz, E.L.1    Baptiste, N.2    Wadler, S.3    Makower, D.4
  • 10
    • 0029100420 scopus 로고
    • Increased sensitivity to the prodrug 5′-deoxy-5-fluorouridine and modulation of 5-fluoro-2′-desoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase
    • Patterson, A. V., Zhang, H., Maghaddam, A., Bicknell, T., Talbot, D. C., Straford, I. J., and Harris, A. L. Increased sensitivity to the prodrug 5′-deoxy-5-fluorouridine and modulation of 5-fluoro-2′-desoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase. Br. J. Cancer, 72: 669-675, 1995.
    • (1995) Br. J. Cancer , vol.72 , pp. 669-675
    • Patterson, A.V.1    Zhang, H.2    Maghaddam, A.3    Bicknell, T.4    Talbot, D.C.5    Straford, I.J.6    Harris, A.L.7
  • 11
    • 0019415841 scopus 로고
    • Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil
    • Evans, R. M., Laskin, J. D., and Hakala, M. T. Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil. Cancer Res., 41: 3288-3295, 1981. (Pubitemid 11063590)
    • (1981) Cancer Research , vol.41 , Issue.9 I , pp. 3288-3295
    • Evans, R.M.1    Laskin, J.D.2    Hakala, M.T.3
  • 12
    • 0029102247 scopus 로고
    • 5-Ethoxy-2′-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression
    • Schwartz, E. L., Baptiste, N., Megati, S., Wadler, S., and Otter, B. A. 5-Ethoxy-2′-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression. Cancer Res., 55: 3543-3550, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 3543-3550
    • Schwartz, E.L.1    Baptiste, N.2    Megati, S.3    Wadler, S.4    Otter, B.A.5
  • 13
    • 0034034356 scopus 로고    scopus 로고
    • Monitoring of the intracellular activation of 5-fluorouracil to deoxyribonucleotides in HT29 human colon cell line: Application to modulation of metabolism and cytotoxicity study
    • PII S0767398100001365
    • Ciccolini, J., Peillard, L., Aubert, C., Formento, P., Milano, G., and Catalin, J. Monitoring of intracellular activation of FUra to deoxyribonucleotides in HT29 human colon cell line: application to modulation of metabolism and cytotoxicity study. Fundam. Clin. Pharmacol., 14: 147-154, 2000. (Pubitemid 30204975)
    • (2000) Fundamental and Clinical Pharmacology , vol.14 , Issue.2 , pp. 147-154
    • Ciccolini, J.1    Peillard, L.2    Aubert, C.3    Formento, P.4    Milano, G.5    Catalin, J.6
  • 14
    • 0344267645 scopus 로고    scopus 로고
    • Enhancement of 5-fluorouracil cytotoxicity by human thymidine- phosphorylase expression in cancer cells: In vitro and in vivo study
    • DOI 10.1002/(SICI)1097-0215(19990129)80:3<465:
    • Evrard, A., Cuq, P., Robert, B., Vian, L., Pelegrin, A., and Cano, J. P. Enhancement of 5-fluorouracil cytotoxicity by human thymidine-phosphorylase expression in cancer cells: in vitro and in vivo study. Int. J. Cancer, 80: 465-470, 1999. (Pubitemid 29019637)
    • (1999) International Journal of Cancer , vol.80 , Issue.3 , pp. 465-470
    • Evrard, A.1    Pierre, C.2    Robert, B.3    Vian, L.4    Pelegrin, A.5    Cano, J.-P.6
  • 15
    • 0032797555 scopus 로고    scopus 로고
    • Increased cytotoxicity and bystander effect of 5-fluorouracil and 5'-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase
    • DOI 10.1038/sj.bjc.6690589
    • Evrard, A., Cuq, P., Ciccolini, J., Vian, L., and Cano, J. P. Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase. Br. J. Cancer, 80: 1726-1733, 1999. (Pubitemid 29389624)
    • (1999) British Journal of Cancer , vol.80 , Issue.11 , pp. 1726-1733
    • Evrard, A.1    Cuq, P.2    Ciccolini, J.3    Vian, L.4    Cano, J.-P.5
  • 17
    • 0034007617 scopus 로고    scopus 로고
    • Enhanced antitumor activity of 5-fluorouracil in combination with 2'- deoxyinosine in human colorectal cell lines and human colon tumor xenografts
    • Ciccolini, J., Peillard, L., Evrard, A., Cuq, P., Aubert, C., Pelegrin, A., Cano, J. P., and Catalin, J. Enhanced antitumor activity of 5-FU in combination with 2′-deoxyinosine in human colorectal cell lines and human colon tumor xenografts. Clin. Cancer Res., 6: 1529-1535, 2000. (Pubitemid 30226243)
    • (2000) Clinical Cancer Research , vol.6 , Issue.4 , pp. 1529-1535
    • Ciccolini, J.1    Peillard, L.2    Evrard, A.3    Cuq, P.4    Aubert, C.5    Pelegrin, A.6    Formento, P.7    Milano, G.8    Catalin, J.9
  • 18
    • 0034632245 scopus 로고    scopus 로고
    • In vitro detection of indirect-acting genotoxins in the comet assay using Hep G2 cells
    • Yusuf, A., Vian, L., Sabatier, R., and Cano, J. P. In vitro detection of indirect-acting genotoxins in the comet assay using Hep G2 cells. Mutat. Res., 468: 234-277, 2000.
    • (2000) Mutat. Res. , vol.468 , pp. 234-277
    • Yusuf, A.1    Vian, L.2    Sabatier, R.3    Cano, J.P.4
  • 19
    • 0032775984 scopus 로고    scopus 로고
    • Clinical implications of 5-fluorouracil modulation
    • Huntington
    • Rustum, Y. M. Clinical implications of 5-fluorouracil modulation. Oncology (Huntington), 7: 22-25, 1999.
    • (1999) Oncology , vol.7 , pp. 22-25
    • Rustum, Y.M.1
  • 20
    • 0034114654 scopus 로고    scopus 로고
    • Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors
    • DOI 10.1023/A:1008351221345
    • Van Triest, B., Pinedo, H. M., Giaccone, G., and Peters, G. J. Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors. Ann. Oncol., 14: 385-391, 2000. (Pubitemid 30333539)
    • (2000) Annals of Oncology , vol.11 , Issue.4 , pp. 385-391
    • Van Triest, B.1    Pinedo, H.M.2    Giaccone, G.3    Peters, G.J.4
  • 21
    • 0026513540 scopus 로고
    • Mechanisms of resistance to fluoropyrimidines
    • Zhang, Z. G., Harstrick, A., and Rustum, Y. M. Mechanisms of resistance to fluoropyrimidines. Semin. Oncol., 19: 4-9, 1992.
    • (1992) Semin. Oncol. , vol.19 , pp. 4-9
    • Zhang, Z.G.1    Harstrick, A.2    Rustum, Y.M.3
  • 22
    • 0027523136 scopus 로고
    • Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine
    • DOI 10.1016/0006-2952(93)90262-U
    • Zhang, Z. G., Malmberg, M., Yin, M. B., Slocum, H. K., and Rustum, Y. M. Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine. Biochem. Pharmacol., 45: 1157-1164, 1993. (Pubitemid 23079995)
    • (1993) Biochemical Pharmacology , vol.45 , Issue.5 , pp. 1157-1164
    • Zhang, Z.-G.1    Malmberg, M.2    Yin, M.-B.3    Slocum, H.K.4    Rustum, Y.M.5
  • 23
    • 0031845428 scopus 로고    scopus 로고
    • Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells
    • Inaba, M., Naoe, Y., and Mitsuhashi, J. Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells. Biol. Pharm. Bull., 21: 569-573, 1998. (Pubitemid 28317310)
    • (1998) Biological and Pharmaceutical Bulletin , vol.21 , Issue.6 , pp. 569-573
    • Inaba, M.1    Naoe, Y.2    Mitsuhashi, J.3
  • 24
    • 0030789906 scopus 로고    scopus 로고
    • Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma
    • Look, K. Y., Moore, D. H., Sutton, G. P., Prajda, N., Abongi, M., and Weber, G. Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma. Anticancer Res., 17: 2353-2356, 1997. (Pubitemid 27352619)
    • (1997) Anticancer Research , vol.17 , Issue.4 A , pp. 2353-2356
    • Look, K.Y.1    Moore, D.H.2    Sutton, G.P.3    Prajda, N.4    Abonyi, M.5    Weber, G.6
  • 25
    • 0034676235 scopus 로고    scopus 로고
    • Establishment and characterization of 5-fluorouracil-resistant gastric cancer cells
    • Chung, Y. M., Park, S., Park, J. K., Kim, Y., Kang, Y., and Yoo, Y. D. Establishment and characterization of 5-fluorouracil-resistant gastric cancer cells. Cancer Lett., 159: 95-101, 2000.
    • (2000) Cancer Lett. , vol.159 , pp. 95-101
    • Chung, Y.M.1    Park, S.2    Park, J.K.3    Kim, Y.4    Kang, Y.5    Yoo, Y.D.6
  • 26
    • 0030709199 scopus 로고    scopus 로고
    • Transcription and activity of 5-fluorouracil converting enzymes in fluoropyrimidine resistance in colon cancer in vitro
    • DOI 10.1016/S0006-2952(97)00330-4, PII S0006295297003304
    • Mader, R. M., Sieder, A. E., Braun, J., Rizovski, B., Kalipuiyan, M., Mueller, M. W., Jakesz, R., Rainer, H., and Steger, G. G. Transcription and activity of 5-fluorouracil converting enzymes in fluoropyrimidine resistance in colon cancer in vitro. Biochem. Pharmacol., 54: 1233-1242, 1997. (Pubitemid 27497250)
    • (1997) Biochemical Pharmacology , vol.54 , Issue.11 , pp. 1233-1242
    • Mader, R.M.1    Sieder, A.E.2    Braun, J.3    Rizovski, B.4    Kalipciyan, M.5    Mueller, M.W.6    Jakesz, R.7    Rainer, H.8    Steger, G.G.9
  • 27
    • 0035875466 scopus 로고    scopus 로고
    • Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase
    • DOI 10.1054/bjoc.2001.1833
    • Cuq, P., Evrard, A., Ciccolini, J., Vian, L., and Cano, J. P Fluoropyrimidine sensitivity of human MCF7 breast cancer cells stably transfected with human uridine phosphorylase. Br. J. Cancer, 84: 1677-1680, 2001. (Pubitemid 32612501)
    • (2001) British Journal of Cancer , vol.84 , Issue.12 , pp. 1677-1680
    • Cuq, P.1    Rouquet, C.2    Evrard, A.3    Ciccolini, J.4    Vian, L.5    Cano, J.-P.6
  • 28
    • 77049163441 scopus 로고
    • The enzymatic synthesis of nucleosides. II. Thymidine and related pyrimidine nucleosides
    • Friedkin, M., and Roberts, D. The enzymatic synthesis of nucleosides. II. Thymidine and related pyrimidine nucleosides. J. Biol. Chem., 207: 257-266, 1957.
    • (1957) J. Biol. Chem. , vol.207 , pp. 257-266
    • Friedkin, M.1    Roberts, D.2
  • 29
    • 0023571156 scopus 로고
    • Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity
    • DOI 10.1016/0277-5379(87)90053-8
    • Peters, G. J., Laurensse, E., Leyva, A., and Pinedo, H. M. Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity. Eur. J. Cancer Clin. Oncol., 23: 1869-1881, 1987. (Pubitemid 18013328)
    • (1987) European Journal of Cancer and Clinical Oncology , vol.23 , Issue.12 , pp. 1869-1881
    • Peters, G.J.1    Laurensse, E.2    Leyva, A.3    Pinedo, H.M.4
  • 31
    • 0017650789 scopus 로고
    • Ribose 1-phosphate metabolism in Ehrlich ascites tumor cells in vitro
    • Barankiewicz, J., and Henderson, J. F. Ribose 1-phosphate metabolism in Erlich ascites tumor cells in vitro. Biochim. Biophys. Acta, 479: 371-377, 1977. (Pubitemid 8224010)
    • (1977) Biochimica et Biophysica Acta , vol.479 , Issue.4 , pp. 371-377
    • Barankiewicz, J.1    Henderson, J.F.2
  • 32
    • 0033044686 scopus 로고    scopus 로고
    • A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells
    • Tillman, D. M., Petak, I., and Houghton J. A. A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells. Clin. Cancer Res., 5: 425-430, 1999. (Pubitemid 29085197)
    • (1999) Clinical Cancer Research , vol.5 , Issue.2 , pp. 425-430
    • Tillman, D.M.1    Petak, I.2    Houghton, J.A.3
  • 33
    • 1542669884 scopus 로고
    • Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation
    • DOI 10.1073/pnas.77.8.4966
    • Spiegelman, S., Sawyer, R., Nayak, R., Ritzi, E., Stolfi, R., and Martin, D. Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation. Proc. Natl. Acad. Sci. USA, 77: 4966-4970, 1980. (Pubitemid 11236547)
    • (1980) Proceedings of the National Academy of Sciences of the United States of America , vol.77 , Issue.8 I , pp. 4966-4970
    • Spiegelman, S.1    Sawyer, R.2    Nayak, R.3
  • 34
    • 0023190828 scopus 로고
    • Role of thymidine in biochemical modulation: A review
    • O'Dwyer, P. J., King, S. A., Hoth, D. F., and Leyland-Jones, B. Role of thymidine in biochemical modulation: a review. Cancer Res., 47: 3911-3919, 1987. (Pubitemid 17108445)
    • (1987) Cancer Research , vol.47 , Issue.15 , pp. 3911-3919
    • O'Dwyer, P.J.1    King, S.A.2    Hoth, D.F.3    Leyland-Jones, B.4
  • 35
    • 0027815723 scopus 로고
    • Pharmacological modulation of 5-fluorouracil and its clinical implications: An overview
    • Gebbia, V., Testa, A., Borsellino, N., Cannata, G., Valenza, R., and Gebbia, N. Pharmacological modulation of 5-fluorouracil and its clinical implications: an overview. In Vivo, 7: 639-644, 1993. (Pubitemid 24095986)
    • (1993) In Vivo , vol.7 , Issue.6 B , pp. 639-644
    • Gebbia, V.1    Testa, A.2    Borsellino, N.3    Cannata, G.4    Valenza, R.5    Gebbia, N.6
  • 36
    • 0023681959 scopus 로고
    • Increased levels of DNA lesions induced by leucovorin-5-fluoropyrimidine in human colon adenocarcinoma
    • Lonn, U., and Lonn, S. Increased levels of DNA lesions induced by leucovorin-5-fluoropyrimidine in human colon adenocarcinoma. Cancer Res., 48: 4153-4157, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 4153-4157
    • Lonn, U.1    Lonn, S.2
  • 37
    • 0030476807 scopus 로고    scopus 로고
    • Metabolism of adenosine and deoxyadenosine by human erythrocytes and CCRF-CEM leukemia cells
    • DOI 10.1016/S1357-2725(96)00080-5, PII S1357272596000805
    • Szabados, E., Duggleby, R. G., and Christopherson, R. I. Metabolism of adenosine and deoxyadenosine by human erythrocytes and CCR-FCEM leukemia cells. Int. J. Biochem. Cell. Biol., 28: 1405-1415, 1996. (Pubitemid 27037929)
    • (1996) International Journal of Biochemistry and Cell Biology , vol.28 , Issue.12 , pp. 1405-1415
    • Szabados, E.1    Duggleby, R.G.2    Christopherson, R.I.3
  • 38
    • 0029837638 scopus 로고    scopus 로고
    • What is the role of thymidine phosphorylase in tumor angiogenesis?
    • Folkman, J. What is the role of thymidine phosphorylase in tumor angiogenesis. J. Natl. Cancer Inst. (Bethesda), 88: 1091-1092, 1996. (Pubitemid 26274601)
    • (1996) Journal of the National Cancer Institute , vol.88 , Issue.16 , pp. 1091-1092
    • Folkman, J.1
  • 39
    • 0031938207 scopus 로고    scopus 로고
    • Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer
    • Takahashi, Y., Bucana, C. D., Akagi, Y., Liu, W., Cleary, K. R., Mai, M., and Ellis, L. M. Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer. Clin. Cancer Res., 4: 429-434, 1998. (Pubitemid 28122759)
    • (1998) Clinical Cancer Research , vol.4 , Issue.2 , pp. 429-434
    • Takahashi, Y.1    Bucana, C.D.2    Akagi, Y.3    Liu, W.4    Cleary, K.R.5    Mai, M.6    Ellis, L.M.7
  • 40
    • 0034048729 scopus 로고    scopus 로고
    • Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
    • Salonga, D., Danenberg, K. D., Johnson, M., Metzger, R., and. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin. Cancer Res., 6: 1322-1327, 2000.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1322-1327
    • Salonga, D.1    Danenberg, K.D.2    Johnson, M.3    Metzger, R.4
  • 42
    • 0033390825 scopus 로고    scopus 로고
    • Thymidine phosphorylase expression in invasive carcinoma: Correlations with clinicopathologic variables and in vitro chemosensitivity to 5-fluorouracil
    • Yang, Q., Shan, L., Yoshimura, G., Taniguchi, E., Suzuma, T., Nakamura, Y., Nakamura, M., Utsunomiya, H., Tang, W., Sakurai, T., and Kakudo, K. Thymidine phosphorylase expression in invasive carcinoma: correlations with clinicopathologic variables and in vitro chemosensitivity to 5-FU. Anticancer Res., 19: 5543-5546, 1999. (Pubitemid 30093323)
    • (1999) Anticancer Research , vol.19 , Issue.6 C , pp. 5543-5546
    • Yang, Q.1    Shan, L.2    Yoshimura, G.3    Taniguchi, E.4    Suzuma, T.5    Nakamura, Y.6    Nakamura, M.7    Utsunomiya, H.8    Tang, W.9    Sakurai, T.10    Kakudo, K.11
  • 43
    • 0030895912 scopus 로고    scopus 로고
    • Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF
    • DOI 10.1023/A:1008280110558
    • Fox, S. B., Engels, K., Comley, M., Whitehouse, R. M., Turley, H., Gatter, K. C., and Harris, A. L. Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF. Ann. Oncol., 8: 271-275, 1997. (Pubitemid 27153494)
    • (1997) Annals of Oncology , vol.8 , Issue.3 , pp. 271-275
    • Fox, S.B.1    Engels, K.2    Comley, M.3    Whitehouse, R.M.4    Turley, H.5    Gatter, K.C.6    Harris, A.L.7
  • 44
    • 0032864482 scopus 로고    scopus 로고
    • The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivatives in advanced gastric carcinoma
    • DOI 10.1038/sj.bjc.6690719
    • Saito, H., Tsujitani, S., Oka, S., Kondo, A., Ikeguchi, M., Maeta, M., and Kaibara, N. The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivatives in advanced gastric carcinoma. Br. J. Cancer, 81: 484-489, 1999. (Pubitemid 29458803)
    • (1999) British Journal of Cancer , vol.81 , Issue.3 , pp. 484-489
    • Saito, H.1    Tsujitani, S.2    Oka, S.3    Kondo, A.4    Ikeguchi, M.5    Maeta, M.6    Kaibara, N.7
  • 45
    • 0033178019 scopus 로고    scopus 로고
    • Thymidine phosphorylase: Its role in sensitivity and resistance to anticancer drugs
    • DOI 10.1054/drup.1999.0089
    • Ackland, S. P., and Peters, G. J. Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs. Drug Resistance Updates, 2: 205-214, 1999. (Pubitemid 29526244)
    • (1999) Drug Resistance Updates , vol.2 , Issue.4 , pp. 205-214
    • Ackland, S.P.1    Peters, G.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.