Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients

Journal of Medical Virology

Volumn 83, Issue 1, 2011, Pages 65-70

  Lee, Seoung Ae ^a   Mun, Ho Suk ^a   Kim, Hong ^a   Lee, Hyung Ki ^a   Kim, Buyng Jun ^a   Hwang, Eung Soo ^a   Kook, Yoon Hoh ^a   Kim, Bum Joon ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

Deletion; Genotype C; Hepatitis B virus (HBV); Insertion; X regions

Indexed keywords

HEPATITIS B VIRUS X PROTEIN;

ADULT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CLINICAL ASSESSMENT; CODON; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HEPATITIS B; HUMAN; KOREA; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PHYLOGENY; VIRAL GENETICS;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA, HEPATOCELLULAR; CARRIER STATE; DNA, VIRAL; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MUTAGENESIS, INSERTIONAL; REPUBLIC OF KOREA; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; SEVERITY OF ILLNESS INDEX; TRANS-ACTIVATORS;

HEPATITIS B VIRUS;

EID: 78649537401     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21938     Document Type: Article

References (34)

1. Baptista M, Kramvis A, Kew MC. 1999. High prevalence of 1762(T) 1764(A) mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers. Hepatology 29: 946-953.
2. Bruix J, Castells A, Bosch J, Feu F, Fuster J, Garcia- Pagan JC, Visa J, Bru C, Rodés J. 1996. Surgical resection of hepatocellular carcinoma in cirrhotic patients: Prognostic value of preoperative portal pressure. Gastroenterology 111: 1018-1022.
3. Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M, Rodés J, EASL Panel of Experts on HCC. 2001. Clinical management of hepatocellular carcinoma. Conclusions of the Barocelona- 2000 EASL conference. J Hepatol 35: 421-430.
4. Brunetto MR, Rodriguez UA, Bonino F. 1999. Hepatitis B virus mutants. Intervirology 42: 69-80.
5. Di Lelio A, Cestari C, Lomazzi A, Beretta L. 1989. Cirrhosis: Diagnosis with sonographic study of the liver surface. Radiology 172: 389-392.
6. Kao JH. 2002. Hepatitis B viral genotypes: Clinical relevance and molecular characteristics. J Gastroenterol Hepatol 17: 643-650.
7. Kao JH. 2003. Hepatitis B virus genotypes and hepatocellular carcinoma in Taiwan. Intervirology 46: 400-407.
8. Kim H, Jee YM, Song BC, Hyun JW, Mun HS, Kim HJ, Oh EJ, Yoon JH, Kim YJ, Lee HS, Hwang ES, Cha CY, Kook YH, Kim BJ. 2007a. Analysis of Hepatitis B virus quasispecies distribution in a Korean chronic patient based on the Full genome sequences. J Med Virol 77: 212-219.
9. Kim H, Jee YM, Song BC, Shin JW, Yang SH, Mun HS, Kim HJ, Oh EJ, Yoon JH, Kim YJ, Lee HS, Hwang ES, Cha CY, Kook YH, Kim BJ. 2007b. Molecular epidemiology of hepatitis B virus (HBV) genotypes and serotypes in patients with chronic HBV infection in Korea. Intervirology 50: 52-57.
10. Kim HJ, Park JH, Jee Y, Lee SA, Kim H, Song BC, Yang S, Lee M, Yoon JH, Kim YJ, Lee HS, Hwang ES, Kook YH, Kim BJ. 2008. Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection. J Med Virol 80: 1337-1343.
11. Kumar S, Tamura K, Jakobsen IB, Nei M. 2001. MEGA2: Molecular evolutionary genetics analysis software. Tempe, Arizona, USA: Arizona State University.
12. Kwun HJ, Jang KL. 2004. Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin- dependent kinase inhibitor p21 gene. Nucleic Acids Res 32: 2202-2213.
13. Lee WM. 1997. Hepatitis B virus infection. N Engl J Med 337: 1733-1745.
14. Lee DH, Kim JH, Nam JJ, Kim HR, Shin HR. 2002. Epidemiological findings of hepatitis B infection based on 1998 National Health and Nutrition Survey in Korea. J Korean Med Sci 17: 457-462.
15. Liang TJ, Hasegawa K, Rimon N, Wands JR, Ben- Porath E. 1991. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med 324: 1705-1709.
16. Liu X, Zhang S, Lin J, Zhang S, Feitelson MA, Gao H, Zhu M. 2008. Hepatitis B virus X protein mutants exhibit distinct biological activities in hepatoma Huh7 cells. Biochem Biophys Res Commun 373: 643-647.
17. Lok AS, McMahon BJ. 2001. Practice Guidelines Committee, American Association for the Study of Liver Diseases. Chronic hepatitis B. Hepatology 34: 1225-1241.
18. Ma NF, Lau SH, Hu L, Xie D, Wu J, Yang J, Wang Y, Wu MC, Fung J, Bai X, Tzang CH, Fu L, Yang M, Su YA, Guan XY. 2008. COOH- terminal truncated HBV X protein plays key role in hepatocarcinogenesis. Clin Cancer Res 14: 5061-5068.
19. Minami M, Daimon Y, Mori K, Takashima H, Nakajima T, Itoh Y, Okanoue T. 2005. Hepatitis B virus- related insertional mutagenesis in chronic hepatitis B patients as an early drastic genetic change leading to hepatocarcinogenesis. Oncogene 24: 4340-4348.
20. Mun HS, Lee SA, Jee Y, Kim H, Park JH, Song BC, Yoon JH, Kim YJ, Lee HS, Hyun JW, Hwang ES, Kook YH, Kim BJ. 2008. The prevalence of hepatitis B virus preS deletions occurring naturally in Korean patients infected chronically with genotype C. J Med Virol 80: 1189-1194.
21. Murakami S. 1999. Hepatitis B virus X protein: Structure, function and biology. Intervirology 42: 81-99.
22. Murakami S. 2001. Hepatitis B virus X protein: A multifunctional viral regulator. J Gastroenterol 36: 651-660.
23. Muroyama R, Kato N, Yoshida H, Otsuka M, Moriyama M, Wang Y, Shao RX, Dharel N, Tanaka Y, Ohta M, Tateishi R, Shiina S, Tatsukawa M, Fukai K, Imazeki F, Yokosuka O, Shiratori Y, Omata M. 2006. Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma. J Hepatol 45: 805-812.
24. Orito E, Mizokami M, Sakugawa H, Michitaka K, Ishikawa K, Ichida T, Okanoue T, Yotsuyanagi H, Iino S. 2001. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group. Hepatology 33: 218-223.
25. Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Brechot C. 1999. Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene 18: 4848-4859.
26. Song BC, Kim H, Kim SH, Cha CY, Kook YH, Kim BJ. 2005a. Comparison of full length sequences of hepatitis B virus isolates in hepatocellular carcinoma patients and asymptomatic carriers of Korea. J Med Virol 75: 13-19.
27. Song BC, Kim SH, Kim H, Ying YH, Kim HJ, Kim YJ, Yoon JH, Lee HS, Cha CY, Kook YH, Kim BJ. 2005b. Prevalence of naturally occurring surface antigen variants of hepatitis B virus in Korean patients infected chronically. J Med Virol 76: 194-202.
28. Takahashi K, Akahane Y, Hino K, Ohta Y, Mishiro S. 1998. Hepatitis B virus genomic sequence in the circulation of hepatocellular carcinoma patients: Comparative analysis of 40 full- length isolates. Arch Virol 143: 2313-2326.
29. Takahashi K, Ohta Y, Kanai K, Akahane Y, Iwasa Y, Hino K, Ohno N, Yoshizawa H, Mishiro S. 1999. Clinical implications of mutations C- to- T1653 and T- to- C/A/G1753 of hepatitis B virus genotype C genome in chronic liver disease. Arch Virol 144: 1299-1308.
30. Tang H, Delgermaa L, Huang F, Oishi N, Liu L, He F, Zhao L, Murakami S. 2005. The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. J Virol 79: 5548-5556.
31. Tang H, Oishi N, Kaneko S, Murakami S. 2006. Molecular functions and biological roles of hepatitis B virus X protein. Cancer Sci 97: 977-983.
32. Tu H, Bonura C, Giannini C, Mouly H, Soussan P, Kew M, Paterlini- Bréchot P, Bréchot C, Kremsdorf D. 2001. Biological impact of natural COOH- terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res 61: 7803-7810.
33. Yoo BC, Park JW, Kim HJ, Lee DH, Cha YJ, Park SM. 2003. Precore and core promoter mutations of hepatitis B virus and hepatitis B e antigen- negative chronic hepatitis B in Korea. J Hepatol 38: 98-103.
34. Zhang H, Shan CL, Li N, Zhang X, Zhang XZ, Xu FQ, Zhang S, Qiu LY, Ye LH, Zhang XD. 2008. Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation. Acta Pharmacol Sin 29: 473-480.