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Volumn 373, Issue 4, 2008, Pages 643-647

Hepatitis B virus X protein mutants exhibit distinct biological activities in hepatoma Huh7 cells

Author keywords

Cell cycle; Hepatitis B virus x; Hepatocellular carcinoma; Mutation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HEPATITIS B VIRUS X PROTEIN; MUTANT PROTEIN; PROTEIN MDM2; PROTEIN P53;

EID: 48949115075     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.06.087     Document Type: Article
Times cited : (19)

References (32)
  • 1
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi P.A., and DePinho R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 6 (2006) 674-687
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 2
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson S.S., and Grisham J.W. Molecular pathogenesis of human hepatocellular carcinoma. Nat. Genet. 31 (2002) 339-346
    • (2002) Nat. Genet. , vol.31 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 3
    • 46949106325 scopus 로고    scopus 로고
    • Mutations in the carboxyl terminus of the X protein of Hepatitis B Virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses
    • 10.1093/carcin/bgn111
    • Liu X.H., Wang L., Zhang S.H., Lin J., Zhang S.M., Feitelson M.A., Gao H.J., and Zhu M.H. Mutations in the carboxyl terminus of the X protein of Hepatitis B Virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses. Carcinogenesis (2008) 10.1093/carcin/bgn111
    • (2008) Carcinogenesis
    • Liu, X.H.1    Wang, L.2    Zhang, S.H.3    Lin, J.4    Zhang, S.M.5    Feitelson, M.A.6    Gao, H.J.7    Zhu, M.H.8
  • 4
    • 4444222917 scopus 로고    scopus 로고
    • cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis
    • Ng R.K., Lau C.Y., Lee S.M., Tsui S.K., Fung K.P., and Waye M.M. cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis. Biochem. Biophys. Res. Commun. 322 (2004) 827-835
    • (2004) Biochem. Biophys. Res. Commun. , vol.322 , pp. 827-835
    • Ng, R.K.1    Lau, C.Y.2    Lee, S.M.3    Tsui, S.K.4    Fung, K.P.5    Waye, M.M.6
  • 5
    • 0025907983 scopus 로고
    • HBx gene of hepatitis B virus induces liver cancer in transgenic mice
    • Kim C.M., Koike K., Saito I., Miyamura T., and Jay G. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351 (1991) 317-320
    • (1991) Nature , vol.351 , pp. 317-320
    • Kim, C.M.1    Koike, K.2    Saito, I.3    Miyamura, T.4    Jay, G.5
  • 7
    • 0031949796 scopus 로고    scopus 로고
    • Properties of tumour suppressor p53 in murine hepatocyte lines transformed by hepatitis B virus X protein
    • Schaefer S., Seifer M., Grimmsmann T., Fink L., Wenderhold S., Hohne M.W., and Gerlich W.H. Properties of tumour suppressor p53 in murine hepatocyte lines transformed by hepatitis B virus X protein. J. Gen. Virol. 79 Pt. 4 (1998) 767-777
    • (1998) J. Gen. Virol. , vol.79 , Issue.PART 4 , pp. 767-777
    • Schaefer, S.1    Seifer, M.2    Grimmsmann, T.3    Fink, L.4    Wenderhold, S.5    Hohne, M.W.6    Gerlich, W.H.7
  • 8
    • 0033593214 scopus 로고    scopus 로고
    • Differential immediate early gene expression in conditional hepatitis B virus pX-transforming versus nontransforming hepatocyte cell lines
    • Tarn C., Bilodeau M.L., Hullinger R.L., and Andrisani O.M. Differential immediate early gene expression in conditional hepatitis B virus pX-transforming versus nontransforming hepatocyte cell lines. J. Biol. Chem. 274 (1999) 2327-2336
    • (1999) J. Biol. Chem. , vol.274 , pp. 2327-2336
    • Tarn, C.1    Bilodeau, M.L.2    Hullinger, R.L.3    Andrisani, O.M.4
  • 9
    • 0032529463 scopus 로고    scopus 로고
    • Hepatitis B virus X protein transcription activation domains are neither required nor sufficient for cell transformation
    • Gottlob K., Pagano S., Levrero M., and Graessmann A. Hepatitis B virus X protein transcription activation domains are neither required nor sufficient for cell transformation. Cancer Res. 58 (1998) 3566-3570
    • (1998) Cancer Res. , vol.58 , pp. 3566-3570
    • Gottlob, K.1    Pagano, S.2    Levrero, M.3    Graessmann, A.4
  • 10
    • 0033607041 scopus 로고    scopus 로고
    • Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx
    • Sirma H., Giannini C., Poussin K., Paterlini P., Kremsdorf D., and Brechot C. Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene 18 (1999) 4848-4859
    • (1999) Oncogene , vol.18 , pp. 4848-4859
    • Sirma, H.1    Giannini, C.2    Poussin, K.3    Paterlini, P.4    Kremsdorf, D.5    Brechot, C.6
  • 11
  • 12
    • 0035812298 scopus 로고    scopus 로고
    • Transcriptional repression of p21(waf1) promoter by hepatitis B virus X protein via a p53-independent pathway
    • Ahn J.Y., Chung E.Y., Kwun H.J., and Jang K.L. Transcriptional repression of p21(waf1) promoter by hepatitis B virus X protein via a p53-independent pathway. Gene 275 (2001) 163-168
    • (2001) Gene , vol.275 , pp. 163-168
    • Ahn, J.Y.1    Chung, E.Y.2    Kwun, H.J.3    Jang, K.L.4
  • 14
    • 0034761676 scopus 로고    scopus 로고
    • Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression
    • Qiao L., Leach K., McKinstry R., Gilfor D., Yacoub A., Park J.S., Grant S., Hylemon P.B., Fisher P.B., and Dent P. Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression. Hepatology 34 (2001) 906-917
    • (2001) Hepatology , vol.34 , pp. 906-917
    • Qiao, L.1    Leach, K.2    McKinstry, R.3    Gilfor, D.4    Yacoub, A.5    Park, J.S.6    Grant, S.7    Hylemon, P.B.8    Fisher, P.B.9    Dent, P.10
  • 15
    • 1542720383 scopus 로고    scopus 로고
    • Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity
    • Miyazawa J., Mitoro A., Kawashiri S., Chada K.K., and Imai K. Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity. Cancer Res. 64 (2004) 2024-2029
    • (2004) Cancer Res. , vol.64 , pp. 2024-2029
    • Miyazawa, J.1    Mitoro, A.2    Kawashiri, S.3    Chada, K.K.4    Imai, K.5
  • 16
    • 33845920091 scopus 로고    scopus 로고
    • Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax
    • Liang X., Liu Y., Zhang Q., Gao L., Han L., Ma C., Zhang L., Chen Y.H., and Sun W. Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax. J. Immunol. 178 (2007) 503-510
    • (2007) J. Immunol. , vol.178 , pp. 503-510
    • Liang, X.1    Liu, Y.2    Zhang, Q.3    Gao, L.4    Han, L.5    Ma, C.6    Zhang, L.7    Chen, Y.H.8    Sun, W.9
  • 17
  • 18
    • 0042671276 scopus 로고    scopus 로고
    • Characterisation of hepatitis B virus X protein mutants in tumour and non-tumour liver cells using laser capture microdissection
    • Iavarone M., Trabut J.B., Delpuech O., Carnot F., Colombo M., Kremsdorf D., Brechot C., and Thiers V. Characterisation of hepatitis B virus X protein mutants in tumour and non-tumour liver cells using laser capture microdissection. J. Hepatol. 39 (2003) 253-261
    • (2003) J. Hepatol. , vol.39 , pp. 253-261
    • Iavarone, M.1    Trabut, J.B.2    Delpuech, O.3    Carnot, F.4    Colombo, M.5    Kremsdorf, D.6    Brechot, C.7    Thiers, V.8
  • 19
    • 22144498137 scopus 로고    scopus 로고
    • A proteomics analysis of cellular proteins associated with HBV genotype-specific HBX: potential in identification of early diagnostic markers for HCC
    • Tan T.L., and Chen W.N. A proteomics analysis of cellular proteins associated with HBV genotype-specific HBX: potential in identification of early diagnostic markers for HCC. J. Clin. Virol. 33 (2005) 293-298
    • (2005) J. Clin. Virol. , vol.33 , pp. 293-298
    • Tan, T.L.1    Chen, W.N.2
  • 21
    • 33646052005 scopus 로고    scopus 로고
    • Antisense regulation of expression and transactivation functions of the tumorigenic HBx and c-myc genes
    • Hung L., and Kumar V. Antisense regulation of expression and transactivation functions of the tumorigenic HBx and c-myc genes. Biochem. Biophys. Res. Commun. 344 (2006) 293-299
    • (2006) Biochem. Biophys. Res. Commun. , vol.344 , pp. 293-299
    • Hung, L.1    Kumar, V.2
  • 22
    • 33745220726 scopus 로고    scopus 로고
    • Nuclear BCL-10 expression is common in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and does not correlate with p65 NF-kappaB activation
    • Merzianu M., Jiang L., Lin P., Wang X., Weber D.M., Vadhan-Raj S., Nguyen M.H., Medeiros L.J., and Bueso-Ramos C.E. Nuclear BCL-10 expression is common in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and does not correlate with p65 NF-kappaB activation. Mod. Pathol. 19 (2006) 891-898
    • (2006) Mod. Pathol. , vol.19 , pp. 891-898
    • Merzianu, M.1    Jiang, L.2    Lin, P.3    Wang, X.4    Weber, D.M.5    Vadhan-Raj, S.6    Nguyen, M.H.7    Medeiros, L.J.8    Bueso-Ramos, C.E.9
  • 23
    • 0037427074 scopus 로고    scopus 로고
    • MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells
    • Wang X., Jin D.Y., Wong H.L., Feng H., Wong Y.C., and Tsao S.W. MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells. Oncogene 22 (2003) 109-116
    • (2003) Oncogene , vol.22 , pp. 109-116
    • Wang, X.1    Jin, D.Y.2    Wong, H.L.3    Feng, H.4    Wong, Y.C.5    Tsao, S.W.6
  • 25
    • 33846948601 scopus 로고    scopus 로고
    • The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases
    • Ou D.P., Tao Y.M., Tang F.Q., and Yang L.Y. The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases. Int. J. Cancer 120 (2007) 1208-1214
    • (2007) Int. J. Cancer , vol.120 , pp. 1208-1214
    • Ou, D.P.1    Tao, Y.M.2    Tang, F.Q.3    Yang, L.Y.4
  • 27
    • 0025358757 scopus 로고
    • X antigen polypeptides in the sera of hepatitis B virus-infected patients
    • Feitelson M.A., and Clayton M.M. X antigen polypeptides in the sera of hepatitis B virus-infected patients. Virology 177 (1990) 367-371
    • (1990) Virology , vol.177 , pp. 367-371
    • Feitelson, M.A.1    Clayton, M.M.2
  • 29
    • 34249303417 scopus 로고    scopus 로고
    • Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
    • Feitelson M.A., and Lee J. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett. 252 (2007) 157-170
    • (2007) Cancer Lett. , vol.252 , pp. 157-170
    • Feitelson, M.A.1    Lee, J.2
  • 30
    • 2342484993 scopus 로고    scopus 로고
    • Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene
    • Kwun H.J., and Jang K.L. Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene. Nucleic Acids Res. 32 (2004) 2202-2213
    • (2004) Nucleic Acids Res. , vol.32 , pp. 2202-2213
    • Kwun, H.J.1    Jang, K.L.2
  • 31
    • 37649020435 scopus 로고    scopus 로고
    • Ubiquitin-dependent and -independent proteasomal degradation of hepatitis B virus X protein
    • Kim J.H., Sohn S.Y., Benedict Yen T.S., and Ahn B.Y. Ubiquitin-dependent and -independent proteasomal degradation of hepatitis B virus X protein. Biochem. Biophys. Res. Commun. 366 (2008) 1036-1042
    • (2008) Biochem. Biophys. Res. Commun. , vol.366 , pp. 1036-1042
    • Kim, J.H.1    Sohn, S.Y.2    Benedict Yen, T.S.3    Ahn, B.Y.4


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