A novel hemostatic delivery device for thrombin: Biodegradable poly(D, L-lactide-co-glycolide) 50:50 microspheres

Journal of Biomedical Materials Research - Part A

Volumn 96 A, Issue 1, 2011, Pages 177-185

  Smeets, Ralf ^a   Gerhards, Frank ^a   Stein, Jamal ^a   Pereira Paz, Rui Miguel ^a   Vogt, Stephan ^b   Pautke, Christoph ^b   Weitz, Jochen ^b   Kolk, Andreas ^b  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

controlled drug delivery; hemostasis; microsphere; poly(D, L lactide co glycolide); thrombin release

Indexed keywords

ACTIVE AGENTS; ANTICOAGULANT THERAPY; ANTITHROMBOTIC; BLOOD CLOT FORMATION; BLOOD LOSS; CHROMOGENIC SUBSTRATE; DELIVERY DEVICE; DENTAL SURGERY; DRUG RELEASE; EVAPORATION METHOD; HEMOSTASIS; HEMOSTATIC AGENTS; IN-VITRO; OIL PHASE; POLY(D ,L-LACTIDE-CO- GLYCOLIDE); POLYMER CONCENTRATIONS; RELEASE PROFILES; RELEASE RATE; SOLVENT EVAPORATION METHOD; THROMBIN RELEASE;

AMINO ACIDS; BLOOD; DRUG PRODUCTS; EMULSIFICATION; EMULSIONS; ENZYME ACTIVITY; EVAPORATION; MICROSPHERES; OPTIMIZATION; ORGANIC POLYMERS; POLYMERS; SURGERY;

CONTROLLED DRUG DELIVERY;

CHROMOGENIC SUBSTRATE; MICROSPHERE; POLYGLACTIN; POLYMER; SERINE PROTEINASE; SOLVENT; THROMBIN;

ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; BLOOD CLOT; DENTAL SURGERY; DRUG DELIVERY SYSTEM; EMULSION; ENZYME ACTIVITY; ENZYME RELEASE; FREEZE DRYING; HEMOSTASIS; IN VITRO STUDY; ORTHOPEDIC SURGERY; POROSITY;

ABSORBABLE IMPLANTS; BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; HEMOSTATICS; HUMANS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; SOLVENTS; THROMBIN;

EID: 78649530252     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32970     Document Type: Article

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